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KARS

GENERAL INFORMATION

Gene name

 KARS

Gene description

 Lysyl-tRNA synthetase

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA041345 , HPA041550
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (unfavourable).
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA041345
HPA041550

GENE INFORMATION

Gene name

 KARS (HGNC Symbol)

Synonyms

 DFNB89, KARS1, KARS2

Description

 Lysyl-tRNA synthetase (HGNC Symbol)

Entrez gene summary

 Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 16

Cytoband

 q23.1

Chromosome location (bp)

 75627474 - 75648643

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000065427 (version 83.38)

Entrez gene

 3735

UniProt

 Q15046 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15046

Antibodypedia

 KARS antibodies

PROTEIN BROWSER
KARS-001
KARS-002
KARS-007
KARS-009
KARS-011
KARS-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KARS-001
ENSP00000303043
ENST00000302445
Q15046 [Direct mapping]
Lysine--tRNA ligase
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Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000049 [tRNA binding]
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004824 [lysine-tRNA ligase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006430 [lysyl-tRNA aminoacylation]
GO:0008033 [tRNA processing]
GO:0010467 [gene expression]
GO:0015630 [microtubule cytoskeleton]
GO:0016032 [viral process]
GO:0046872 [metal ion binding]
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 597 aa
68 kDa 		No 0
KARS-002
ENSP00000325448
ENST00000319410
Q15046 [Direct mapping]
Lysine--tRNA ligase
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Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000049 [tRNA binding]
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004824 [lysine-tRNA ligase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006430 [lysyl-tRNA aminoacylation]
GO:0008033 [tRNA processing]
GO:0010467 [gene expression]
GO:0015630 [microtubule cytoskeleton]
GO:0015966 [diadenosine tetraphosphate biosynthetic process]
GO:0016032 [viral process]
GO:0016597 [amino acid binding]
GO:0017101 [aminoacyl-tRNA synthetase multienzyme complex]
GO:0046872 [metal ion binding]
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 625 aa
71.5 kDa 		No 0
KARS-007
ENSP00000462057
ENST00000568682
J3KRL2 [Direct mapping]
Lysine--tRNA ligase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003676 [nucleic acid binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0006418 [tRNA aminoacylation for protein translation]
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 102 aa
12.1 kDa 		No 0
KARS-009
ENSP00000454512
ENST00000568378
H3BMR9 [Direct mapping]
Lysine--tRNA ligase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 67 aa
7.7 kDa 		No 0
KARS-011
ENSP00000455488
ENST00000566772
H3BPV7 [Direct mapping]
Lysine--tRNA ligase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0006418 [tRNA aminoacylation for protein translation]
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 104 aa
12.2 kDa 		No 0
KARS-012
ENSP00000458028
ENST00000570215
H3BVA8 [Direct mapping]
Lysine--tRNA ligase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0006418 [tRNA aminoacylation for protein translation]
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 256 aa
29.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.