Expression of ADAT1 in cancer - Summary - The Human Protein Atlas

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ADAT1

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ADAT1
Gene description	Adenosine deaminase, tRNA-specific 1
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

cytoplasmic expression of immune cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 2 antibodies. HPA040713 , HPA040903
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA040713	HPA040903

GENE INFORMATION
Gene name	ADAT1
Synonyms
Description	Adenosine deaminase, tRNA-specific 1 (HGNC Symbol)
Entrez gene summary	This gene is a member of the ADAR (adenosine deaminase acting on RNA) family. Using site-specific adenosine modification, proteins encoded by these genes participate in the pre-mRNA editing of nuclear transcripts. The protein encoded by this gene, tRNA-specific adenosine deaminase 1, is responsible for the deamination of adenosine 37 to inosine in eukaryotic tRNA. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010]
Chromosome	16
Cytoband	q23.1
Chromosome location (bp)	75596981 - 75623300
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000065457 (version 83.38)
Entrez gene	23536
UniProt	Q9BUB4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BUB4
Antibodypedia	ADAT1 antibodies

PROTEIN BROWSER

ADAT1-001	ADAT1-005	ADAT1-006	ADAT1-008	ADAT1-010	ADAT1-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADAT1-001 ENSP00000310015 ENST00000307921	Q9BUB4 [Direct mapping] tRNA-specific adenosine deaminase 1 Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0004000 [adenosine deaminase activity] GO:0006396 [RNA processing] GO:0006400 [tRNA modification] GO:0008033 [tRNA processing] GO:0008251 [tRNA-specific adenosine deaminase activity] GO:0010467 [gene expression] GO:0046872 [metal ion binding] Show all	502 aa 55.4 kDa	No	0
ADAT1-005 ENSP00000456751 ENST00000562374	A0A0G2JLA8 [Direct mapping] tRNA-specific adenosine deaminase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		10 aa 1.2 kDa	No	0
ADAT1-006 ENSP00000457501 ENST00000564657	H3BU72 [Direct mapping] tRNA-specific adenosine deaminase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0004000 [adenosine deaminase activity] GO:0006396 [RNA processing] Show all	110 aa 12.3 kDa	No	0
ADAT1-008 ENSP00000455108 ENST00000567281	H3BP18 [Direct mapping] tRNA-specific adenosine deaminase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0004000 [adenosine deaminase activity] GO:0006396 [RNA processing] Show all	161 aa 18.1 kDa	No	0
ADAT1-010 ENSP00000455121 ENST00000566450	H3BP27 [Direct mapping] tRNA-specific adenosine deaminase 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0004000 [adenosine deaminase activity] GO:0006396 [RNA processing] Show all	120 aa 13.6 kDa	No	0
ADAT1-011 ENSP00000455000 ENST00000568510	H3BNT8 [Direct mapping] tRNA-specific adenosine deaminase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		18 aa 2.2 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.