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GSTO2

GENERAL INFORMATION

Gene name

 GSTO2

Gene description

 Glutathione S-transferase omega 2

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (CAPAN-2, hTCEpi, T-47d)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear and cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA048141
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA048141

GENE INFORMATION

Gene name

 GSTO2

Synonyms

Description

 Glutathione S-transferase omega 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is an omega class glutathione S-transferase (GST). GSTs are involved in the metabolism of xenobiotics and carcinogens. Four transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]

Chromosome

 10

Cytoband

 q25.1

Chromosome location (bp)

 104268873 - 104304945

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000065621 (version 83.38)

Entrez gene

 119391

UniProt

 Q9H4Y5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H4Y5

Antibodypedia

 GSTO2 antibodies

PROTEIN BROWSER
GSTO2-001
GSTO2-002
GSTO2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GSTO2-001
ENSP00000345023
ENST00000338595
Q9H4Y5 [Direct mapping]
Glutathione S-transferase omega-2
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Enzymes
   ENZYME proteins
   Oxidoreductases
   Transferases
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0004364 [glutathione transferase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006749 [glutathione metabolic process]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0019852 [L-ascorbic acid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045174 [glutathione dehydrogenase (ascorbate) activity]
GO:0050610 [methylarsonate reductase activity]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:0071243 [cellular response to arsenic-containing substance]
GO:1901687 [glutathione derivative biosynthetic process]
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 243 aa
28.3 kDa 		No 0
GSTO2-002
ENSP00000358721
ENST00000369707
Q9H4Y5 [Direct mapping]
Glutathione S-transferase omega-2
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Enzymes
   ENZYME proteins
   Oxidoreductases
   Transferases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0004364 [glutathione transferase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006749 [glutathione metabolic process]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0019852 [L-ascorbic acid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045174 [glutathione dehydrogenase (ascorbate) activity]
GO:0050610 [methylarsonate reductase activity]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:0071243 [cellular response to arsenic-containing substance]
GO:1901687 [glutathione derivative biosynthetic process]
Show all
 215 aa
25.4 kDa 		No 0
GSTO2-201
ENSP00000390986
ENST00000450629
Q9H4Y5 [Direct mapping]
Glutathione S-transferase omega-2
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Enzymes
   ENZYME proteins
   Oxidoreductases
   Transferases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0004364 [glutathione transferase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006749 [glutathione metabolic process]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0019852 [L-ascorbic acid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045174 [glutathione dehydrogenase (ascorbate) activity]
GO:0050610 [methylarsonate reductase activity]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:0071243 [cellular response to arsenic-containing substance]
GO:1901687 [glutathione derivative biosynthetic process]
Show all
 209 aa
24.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.