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PRKCQ

GENERAL INFORMATION

Gene name

 PRKCQ

Gene description

 Protein kinase C, theta

Protein class

 Cancer-related genes
Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (skeletal muscle)
GTEx:Tissue enhanced (skeletal muscle)
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skeletal muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skeletal muscle)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 PRKCQ

Synonyms

Description

 Protein kinase C, theta (HGNC Symbol)

Entrez gene summary

 Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors. [provided by RefSeq, Jul 2008]

Chromosome

 10

Cytoband

 p15.1

Chromosome location (bp)

 6427143 - 6580301

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000065675 (version 83.38)

Entrez gene

 5588

UniProt

 Q04759 (UniProt - Evidence at protein level)

neXtProt

 NX_Q04759

Antibodypedia

 PRKCQ antibodies

PROTEIN BROWSER
PRKCQ-001
PRKCQ-201
PRKCQ-202
PRKCQ-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PRKCQ-001
ENSP00000263125
ENST00000263125
Q04759 [Direct mapping]
Protein kinase C theta type
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0001666 [response to hypoxia]
GO:0001772 [immunological synapse]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004697 [protein kinase C activity]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006509 [membrane protein ectodomain proteolysis]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0006954 [inflammatory response]
GO:0007411 [axon guidance]
GO:0007568 [aging]
GO:0007596 [blood coagulation]
GO:0007603 [phototransduction, visible light]
GO:0009408 [response to heat]
GO:0009749 [response to glucose]
GO:0010389 [regulation of G2/M transition of mitotic cell cycle]
GO:0012501 [programmed cell death]
GO:0014070 [response to organic cyclic compound]
GO:0016020 [membrane]
GO:0016056 [rhodopsin mediated signaling pathway]
GO:0016567 [protein ubiquitination]
GO:0019229 [regulation of vasoconstriction]
GO:0022400 [regulation of rhodopsin mediated signaling pathway]
GO:0030168 [platelet activation]
GO:0030182 [neuron differentiation]
GO:0031594 [neuromuscular junction]
GO:0032740 [positive regulation of interleukin-17 production]
GO:0032753 [positive regulation of interleukin-4 production]
GO:0032868 [response to insulin]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042102 [positive regulation of T cell proliferation]
GO:0042246 [tissue regeneration]
GO:0042346 [positive regulation of NF-kappaB import into nucleus]
GO:0042383 [sarcolemma]
GO:0045086 [positive regulation of interleukin-2 biosynthetic process]
GO:0045087 [innate immune response]
GO:0045730 [respiratory burst]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
GO:0046872 [metal ion binding]
GO:0050714 [positive regulation of protein secretion]
GO:0050852 [T cell receptor signaling pathway]
GO:0050870 [positive regulation of T cell activation]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051491 [positive regulation of filopodium assembly]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0060326 [cell chemotaxis]
GO:0070233 [negative regulation of T cell apoptotic process]
GO:0090330 [regulation of platelet aggregation]
GO:2000318 [positive regulation of T-helper 17 type immune response]
GO:2000570 [positive regulation of T-helper 2 cell activation]
Show all
 706 aa
81.9 kDa 		No 0
PRKCQ-201
ENSP00000380361
ENST00000397176
Q04759 [Direct mapping]
Protein kinase C theta type
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004697 [protein kinase C activity]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006509 [membrane protein ectodomain proteolysis]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0006954 [inflammatory response]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0007603 [phototransduction, visible light]
GO:0012501 [programmed cell death]
GO:0016056 [rhodopsin mediated signaling pathway]
GO:0016567 [protein ubiquitination]
GO:0022400 [regulation of rhodopsin mediated signaling pathway]
GO:0030168 [platelet activation]
GO:0032740 [positive regulation of interleukin-17 production]
GO:0032753 [positive regulation of interleukin-4 production]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0045087 [innate immune response]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
GO:0046872 [metal ion binding]
GO:0050852 [T cell receptor signaling pathway]
GO:0050870 [positive regulation of T cell activation]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0060326 [cell chemotaxis]
GO:0070233 [negative regulation of T cell apoptotic process]
GO:0090330 [regulation of platelet aggregation]
GO:2000318 [positive regulation of T-helper 17 type immune response]
GO:2000570 [positive regulation of T-helper 2 cell activation]
Show all
 643 aa
74.3 kDa 		No 0
PRKCQ-202
ENSP00000441752
ENST00000539722
Q04759 [Direct mapping]
Protein kinase C theta type
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004697 [protein kinase C activity]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006509 [membrane protein ectodomain proteolysis]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0006954 [inflammatory response]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0007603 [phototransduction, visible light]
GO:0012501 [programmed cell death]
GO:0016056 [rhodopsin mediated signaling pathway]
GO:0016567 [protein ubiquitination]
GO:0022400 [regulation of rhodopsin mediated signaling pathway]
GO:0030168 [platelet activation]
GO:0032740 [positive regulation of interleukin-17 production]
GO:0032753 [positive regulation of interleukin-4 production]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0045087 [innate immune response]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
GO:0046872 [metal ion binding]
GO:0050852 [T cell receptor signaling pathway]
GO:0050870 [positive regulation of T cell activation]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0060326 [cell chemotaxis]
GO:0070233 [negative regulation of T cell apoptotic process]
GO:0090330 [regulation of platelet aggregation]
GO:2000318 [positive regulation of T-helper 17 type immune response]
GO:2000570 [positive regulation of T-helper 2 cell activation]
Show all
 581 aa
67.6 kDa 		No 0
PRKCQ-203
ENSP00000483428
ENST00000610727
A0A087X0I9 [Direct mapping]
Protein kinase C
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004697 [protein kinase C activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0035556 [intracellular signal transduction]
GO:0046872 [metal ion binding]
Show all
 670 aa
78 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.