Expression of ASB1 in cancer - Summary - The Human Protein Atlas

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ASB1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ASB1
Gene description	Ankyrin repeat and SOCS box containing 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Expression in CNS, adrenal medulla, parathyroid gland and enteroendocrine cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA003508
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable), pancreatic cancer (favourable) and liver cancer (unfavourable).
Endometrial cancer p<0.001 Pancreatic cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

Pancreatic cancer

STAINING SUMMARY

HPA003508

GENE INFORMATION
Gene name	ASB1 (HGNC Symbol)
Synonyms	ASB-1
Description	Ankyrin repeat and SOCS box containing 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	q37.3
Chromosome location (bp)	238426742 - 238452250
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000065802 (version 83.38)
Entrez gene	51665
UniProt	Q9Y576 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y576
Antibodypedia	ASB1 antibodies

PROTEIN BROWSER

ASB1-001	ASB1-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ASB1-001 ENSP00000264607 ENST00000264607	Q9Y576 [Direct mapping] Ankyrin repeat and SOCS box protein 1 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0016567 [protein ubiquitination] GO:0030539 [male genitalia development] GO:0035556 [intracellular signal transduction] GO:0042036 [negative regulation of cytokine biosynthetic process] Show all	335 aa 37 kDa	No	0
ASB1-004 ENSP00000387025 ENST00000409297	B9A047 [Direct mapping] Ankyrin repeat and SOCS box protein 1 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0016567 [protein ubiquitination] GO:0035556 [intracellular signal transduction] Show all	234 aa 26.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.