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CDK13

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GENERAL INFORMATION

Gene name

 CDK13

Gene description

 Cyclin-dependent kinase 13

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nuclear speckles.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nuclear speckles (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA059241
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nuclear speckles.

Main location

 Nuclear speckles (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA059241 HeLa Nuclear speckles
Golgi apparatus
HPA059241 SiHa Nuclear speckles
Cytosol
HPA059241 U-2 OS No staining    

GENE INFORMATION

Gene name

 CDK13 (HGNC Symbol)

Synonyms

 CDC2L, CDC2L5, CHED, KIAA1791

Description

 Cyclin-dependent kinase 13 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the cyclin-dependent serine/threonine protein kinase family. Members of this family are well known for their essential roles as master switches in cell cycle control. The exact function of this protein has not yet been determined, but it may play a role in mRNA processing and may be involved in regulation of hematopoiesis. Alternatively spliced transcript variants have been described.[provided by RefSeq, Dec 2009]

Chromosome

 7

Cytoband

 p14.1

Chromosome location (bp)

 39950037 - 40097134

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000065883 (version 83.38)

Entrez gene

 8621

UniProt

 Q14004 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14004

Antibodypedia

 CDK13 antibodies

PROTEIN BROWSER
CDK13-001
CDK13-002
CDK13-201
CDK13-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CDK13-001
ENSP00000181839
ENST00000181839
Q14004 [Direct mapping]
Cyclin-dependent kinase 13
A0A024RA85 [Target identity:100%; Query identity:100%]
Cell division cycle 2-like 5 (Cholinesterase-related cell division controller), isoform CRA_a
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000380 [alternative mRNA splicing, via spliceosome]
GO:0002945 [cyclin K-CDK13 complex]
GO:0004672 [protein kinase activity]
GO:0004693 [cyclin-dependent protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0006468 [protein phosphorylation]
GO:0007088 [regulation of mitotic nuclear division]
GO:0007275 [multicellular organismal development]
GO:0008284 [positive regulation of cell proliferation]
GO:0008353 [RNA polymerase II carboxy-terminal domain kinase activity]
GO:0016032 [viral process]
GO:0016607 [nuclear speck]
GO:0019908 [nuclear cyclin-dependent protein kinase holoenzyme complex]
GO:0030097 [hemopoiesis]
GO:0030332 [cyclin binding]
GO:0044822 [poly(A) RNA binding]
GO:0070816 [phosphorylation of RNA polymerase II C-terminal domain]
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 1512 aa
164.9 kDa 		No 0
CDK13-002
ENSP00000340557
ENST00000340829
Q14004 [Direct mapping]
Cyclin-dependent kinase 13
A0A024RA66 [Target identity:100%; Query identity:100%]
Cell division cycle 2-like 5 (Cholinesterase-related cell division controller), isoform CRA_b
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000380 [alternative mRNA splicing, via spliceosome]
GO:0002945 [cyclin K-CDK13 complex]
GO:0004672 [protein kinase activity]
GO:0004693 [cyclin-dependent protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0006468 [protein phosphorylation]
GO:0007088 [regulation of mitotic nuclear division]
GO:0007275 [multicellular organismal development]
GO:0008284 [positive regulation of cell proliferation]
GO:0008353 [RNA polymerase II carboxy-terminal domain kinase activity]
GO:0016032 [viral process]
GO:0016607 [nuclear speck]
GO:0019908 [nuclear cyclin-dependent protein kinase holoenzyme complex]
GO:0030097 [hemopoiesis]
GO:0030332 [cyclin binding]
GO:0044822 [poly(A) RNA binding]
GO:0070816 [phosphorylation of RNA polymerase II C-terminal domain]
Show all
 1452 aa
158.4 kDa 		No 0
CDK13-201
ENSP00000484610
ENST00000611390
A0A087X209 [Direct mapping]
Cyclin-dependent kinase 13
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
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 418 aa
48.2 kDa 		No 0
CDK13-202
ENSP00000480835
ENST00000613626
Q9BVE2 [Direct mapping]
CDC2L5 protein; Cyclin-dependent kinase 13
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   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 324 aa
37.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.