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Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
This gene encodes a highly conserved cold shock domain protein that has broad nucleic acid binding properties. The encoded protein functions as both a DNA and RNA binding protein and has been implicated in numerous cellular processes including regulation of transcription and translation, pre-mRNA splicing, DNA reparation and mRNA packaging. This protein is also a component of messenger ribonucleoprotein (mRNP) complexes and may have a role in microRNA processing. This protein can be secreted through non-classical pathways and functions as an extracellular mitogen. Aberrant expression of the gene is associated with cancer proliferation in numerous tissues. This gene may be a prognostic marker for poor outcome and drug resistance in certain cancers. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on multiple chromosomes. [provided by RefSeq, Sep 2015]
P67809 [Direct mapping] Nuclease-sensitive element-binding protein 1
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Predicted intracellular proteins Plasma proteins Transcription factors beta-Barrel DNA-binding domains Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000398 [mRNA splicing, via spliceosome] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001701 [in utero embryonic development] GO:0002039 [p53 binding] GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003690 [double-stranded DNA binding] GO:0003697 [single-stranded DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003723 [RNA binding] GO:0003729 [mRNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005689 [U12-type spliceosomal complex] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0008134 [transcription factor binding] GO:0008284 [positive regulation of cell proliferation] GO:0008380 [RNA splicing] GO:0010467 [gene expression] GO:0010494 [cytoplasmic stress granule] GO:0030425 [dendrite] GO:0030529 [ribonucleoprotein complex] GO:0031965 [nuclear membrane] GO:0043066 [negative regulation of apoptotic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0043565 [sequence-specific DNA binding] GO:0044822 [poly(A) RNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046627 [negative regulation of insulin receptor signaling pathway] GO:0048471 [perinuclear region of cytoplasm] GO:0051020 [GTPase binding] GO:0051154 [negative regulation of striated muscle cell differentiation] GO:0051781 [positive regulation of cell division] GO:0070062 [extracellular exosome] GO:0070934 [CRD-mediated mRNA stabilization] GO:0070937 [CRD-mediated mRNA stability complex] GO:0071204 [histone pre-mRNA 3'end processing complex] GO:1990124 [messenger ribonucleoprotein complex]
