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NGEF

GENERAL INFORMATION

Gene name

 NGEF

Gene description

 Neuronal guanine nucleotide exchange factor

Protein class

 Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (A-431, HDLM-2, PC-3, T-47d)
HPA (normal tissue):Tissue enhanced (adrenal gland, cerebral cortex)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and membranous expression in all tissues, most abundant in cerebral cortex.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Caution, Splice and/or transcript discrepancy exists. Nuclear staining in several tissues viewed as off target and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA008160
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA008160

GENE INFORMATION

Gene name

 NGEF (HGNC Symbol)

Synonyms

 ARHGEF27

Description

 Neuronal guanine nucleotide exchange factor (HGNC Symbol)

Entrez gene summary

Chromosome

 2

Cytoband

 q37.1

Chromosome location (bp)

 232878686 - 233013272

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000066248 (version 83.38)

Entrez gene

 25791

UniProt

 Q8N5V2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8N5V2

Antibodypedia

 NGEF antibodies

PROTEIN BROWSER
NGEF-001
NGEF-002
NGEF-003
NGEF-004
NGEF-008
NGEF-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NGEF-001
ENSP00000264051
ENST00000264051
Q8N5V2 [Direct mapping]
Ephexin-1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0009987 [cellular process]
GO:0016020 [membrane]
GO:0030426 [growth cone]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0043087 [regulation of GTPase activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0061002 [negative regulation of dendritic spine morphogenesis]
GO:0097190 [apoptotic signaling pathway]
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 710 aa
82.5 kDa 		No 0
NGEF-002
ENSP00000387033
ENST00000409079
Q8N5V2 [Direct mapping]
Ephexin-1
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   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005829 [cytosol]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0016020 [membrane]
GO:0030426 [growth cone]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0043087 [regulation of GTPase activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0061002 [negative regulation of dendritic spine morphogenesis]
GO:0097190 [apoptotic signaling pathway]
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 238 aa
26.6 kDa 		No 0
NGEF-003
ENSP00000362653
ENST00000373552
Q8N5V2 [Direct mapping]
Ephexin-1
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0016020 [membrane]
GO:0030426 [growth cone]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0043087 [regulation of GTPase activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0061002 [negative regulation of dendritic spine morphogenesis]
GO:0097190 [apoptotic signaling pathway]
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 618 aa
71.4 kDa 		Yes 0
NGEF-004
ENSP00000401063
ENST00000416114
C9JTV7 [Direct mapping]
Ephexin-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
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 187 aa
22 kDa 		No 0
NGEF-008
ENSP00000387591
ENST00000424488
H7BZ39 [Direct mapping]
Ephexin-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 150 aa
17.5 kDa 		No 0
NGEF-010
ENSP00000405053
ENST00000414326
H7C2C2 [Direct mapping]
Ephexin-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 97 aa
11 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.