Fields »
ABOUT
HELP
BLOG
ASPM

GENERAL INFORMATION

Gene name

 ASPM

Gene description

 Abnormal spindle microtubule assembly

Protein class

 Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Expressed in all
HPA (normal tissue):Tissue enhanced (bone marrow)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression, most abundant in bone marrow.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB017816
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), endometrial cancer (unfavourable), pancreatic cancer (unfavourable) and lung cancer (unfavourable).
Liver cancer p<0.001
Endometrial cancer p<0.001
Pancreatic cancer p<0.001
Lung cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB017816

GENE INFORMATION

Gene name

 ASPM (HGNC Symbol)

Synonyms

 ASP, Calmbp1, FLJ10517, FLJ10549, MCPH5

Description

 Abnormal spindle microtubule assembly (HGNC Symbol)

Entrez gene summary

 This gene is the human ortholog of the Drosophila melanogaster 'abnormal spindle' gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts. Studies in mouse also suggest a role of this gene in mitotic spindle regulation, with a preferential role in regulating neurogenesis. Mutations in this gene are associated with microcephaly primary type 5. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]

Chromosome

 1

Cytoband

 q31.3

Chromosome location (bp)

 197084128 - 197146694

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000066279 (version 83.38)

Entrez gene

 259266

UniProt

 Q8IZT6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8IZT6

Antibodypedia

 ASPM antibodies

PROTEIN BROWSER
ASPM-001
ASPM-002
ASPM-201
ASPM-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ASPM-001
ENSP00000356379
ENST00000367409
Q8IZT6 [Direct mapping]
Abnormal spindle-like microcephaly-associated protein
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000922 [spindle pole]
GO:0001764 [neuron migration]
GO:0002052 [positive regulation of neuroblast proliferation]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005874 [microtubule]
GO:0007051 [spindle organization]
GO:0007067 [mitotic nuclear division]
GO:0007283 [spermatogenesis]
GO:0007420 [brain development]
GO:0008584 [male gonad development]
GO:0021873 [forebrain neuroblast division]
GO:0021987 [cerebral cortex development]
GO:0030496 [midbody]
GO:0036449 [microtubule minus-end]
GO:0045665 [negative regulation of neuron differentiation]
GO:0045769 [negative regulation of asymmetric cell division]
GO:0048477 [oogenesis]
GO:0048589 [developmental growth]
GO:0051445 [regulation of meiotic cell cycle]
GO:0051653 [spindle localization]
GO:0051661 [maintenance of centrosome location]
GO:0072687 [meiotic spindle]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:0090306 [spindle assembly involved in meiosis]
GO:0097150 [neuronal stem cell population maintenance]
GO:0097431 [mitotic spindle pole]
Show all
 3477 aa
409.8 kDa 		No 0
ASPM-002
ENSP00000356378
ENST00000367408
Q5VYL4 [Direct mapping]
Abnormal spindle-like microcephaly-associated protein; Asp (Abnormal spindle)-like, microcephaly associated (Drosophila), isoform CRA_d
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005515 [protein binding]
Show all
 1142 aa
133.6 kDa 		No 0
ASPM-201
ENSP00000294732
ENST00000294732
Q8IZT6 [Direct mapping]
Abnormal spindle-like microcephaly-associated protein
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0007051 [spindle organization]
GO:0007067 [mitotic nuclear division]
GO:0036449 [microtubule minus-end]
GO:0051653 [spindle localization]
GO:0097431 [mitotic spindle pole]
Show all
 1892 aa
217.8 kDa 		No 0
ASPM-202
ENSP00000479244
ENST00000612785
A0A087WV76 [Direct mapping]
Abnormal spindle-like microcephaly-associated protein
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005515 [protein binding]
Show all
 1389 aa
164.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.