Expression of CLDN18 in cancer - Summary - The Human Protein Atlas

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CLDN18

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CLDN18
Gene description	Claudin 18
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (pancreatic cancer, stomach cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Group enriched (lung, stomach)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct membranous expression in stomach.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA018446 , CAB013010 , CAB013243
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (pancreatic cancer, stomach cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA018446	CAB013010	CAB013243

GENE INFORMATION
Gene name	CLDN18 (HGNC Symbol)
Synonyms	SFTPJ
Description	Claudin 18 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2010]
Chromosome	3
Cytoband	q22.3
Chromosome location (bp)	137998735 - 138033655
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000066405 (version 83.38)
Entrez gene	51208
UniProt	P56856 (UniProt - Evidence at transcript level)
neXtProt	NX_P56856
Antibodypedia	CLDN18 antibodies

PROTEIN BROWSER

CLDN18-001	CLDN18-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CLDN18-001 ENSP00000340939 ENST00000343735	P56856 [Direct mapping] Claudin-18 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005886 [plasma membrane] GO:0005923 [bicellular tight junction] GO:0016021 [integral component of membrane] GO:0016338 [calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules] GO:0034329 [cell junction assembly] GO:0042802 [identical protein binding] GO:0045216 [cell-cell junction organization] GO:0070830 [bicellular tight junction assembly] Show all	261 aa 27.7 kDa	No	3
CLDN18-002 ENSP00000183605 ENST00000183605	P56856 [Direct mapping] Claudin-18 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005886 [plasma membrane] GO:0005923 [bicellular tight junction] GO:0016021 [integral component of membrane] GO:0016338 [calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules] GO:0034329 [cell junction assembly] GO:0042802 [identical protein binding] GO:0045216 [cell-cell junction organization] GO:0070830 [bicellular tight junction assembly] Show all	261 aa 27.9 kDa	Yes	3

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.