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FGFR2

GENERAL INFORMATION

Gene name

 FGFR2

Gene description

 Fibroblast growth factor receptor 2

Protein class

 Cancer-related genes
CD markers
Disease related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins
RAS pathway related proteins

Predicted localization

 Intracellular,Membrane,Secreted

Number of transcripts

 19
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (AN3-CA, BEWO, NTERA-2)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 2 antibodies.
HPA035305 , CAB010886
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (favourable) and head and neck cancer (favourable).
Cervical cancer p<0.001
Head and neck cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA035305
CAB010886

GENE INFORMATION

Gene name

 FGFR2 (HGNC Symbol)

Synonyms

 BEK, CD332, CEK3, CFD1, ECT1, JWS, K-SAM, KGFR, TK14, TK25

Description

 Fibroblast growth factor receptor 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]

Chromosome

 10

Cytoband

 q26.13

Chromosome location (bp)

 121478334 - 121598458

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000066468 (version 83.38)

Entrez gene

 2263

UniProt

 P21802 (UniProt - Evidence at protein level)

neXtProt

 NX_P21802

Antibodypedia

 FGFR2 antibodies

PROTEIN BROWSER
«
FGFR2-001
FGFR2-003
FGFR2-004
FGFR2-005
FGFR2-006
FGFR2-007
FGFR2-008
FGFR2-009
FGFR2-010
FGFR2-011
FGFR2-012
FGFR2-016
FGFR2-021
FGFR2-025
FGFR2-026
FGFR2-201
FGFR2-202
FGFR2-203
FGFR2-204
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FGFR2-001
ENSP00000351276
ENST00000358487
P21802 [Direct mapping]
Fibroblast growth factor receptor 2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001525 [angiogenesis]
GO:0001657 [ureteric bud development]
GO:0001701 [in utero embryonic development]
GO:0002053 [positive regulation of mesenchymal cell proliferation]
GO:0003148 [outflow tract septum morphogenesis]
GO:0003149 [membranous septum morphogenesis]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005007 [fibroblast growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005938 [cell cortex]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007267 [cell-cell signaling]
GO:0007409 [axonogenesis]
GO:0007411 [axon guidance]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0008589 [regulation of smoothened signaling pathway]
GO:0009791 [post-embryonic development]
GO:0009880 [embryonic pattern specification]
GO:0009887 [organ morphogenesis]
GO:0009986 [cell surface]
GO:0010453 [regulation of cell fate commitment]
GO:0010518 [positive regulation of phospholipase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016331 [morphogenesis of embryonic epithelium]
GO:0017134 [fibroblast growth factor binding]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0021769 [orbitofrontal cortex development]
GO:0021847 [ventricular zone neuroblast division]
GO:0021860 [pyramidal neuron development]
GO:0022612 [gland morphogenesis]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0030282 [bone mineralization]
GO:0030324 [lung development]
GO:0030855 [epithelial cell differentiation]
GO:0030901 [midbrain development]
GO:0030916 [otic vesicle formation]
GO:0031012 [extracellular matrix]
GO:0031069 [hair follicle morphogenesis]
GO:0032808 [lacrimal gland development]
GO:0033688 [regulation of osteoblast proliferation]
GO:0035264 [multicellular organism growth]
GO:0035265 [organ growth]
GO:0035602 [fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow]
GO:0035603 [fibroblast growth factor receptor signaling pathway involved in hemopoiesis]
GO:0035604 [fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow]
GO:0035607 [fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0040014 [regulation of multicellular organism growth]
GO:0040036 [regulation of fibroblast growth factor receptor signaling pathway]
GO:0042472 [inner ear morphogenesis]
GO:0042476 [odontogenesis]
GO:0042803 [protein homodimerization activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045087 [innate immune response]
GO:0045165 [cell fate commitment]
GO:0045667 [regulation of osteoblast differentiation]
GO:0045787 [positive regulation of cell cycle]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048286 [lung alveolus development]
GO:0048557 [embryonic digestive tract morphogenesis]
GO:0048562 [embryonic organ morphogenesis]
GO:0048565 [digestive tract development]
GO:0048568 [embryonic organ development]
GO:0048608 [reproductive structure development]
GO:0048701 [embryonic cranial skeleton morphogenesis]
GO:0048705 [skeletal system morphogenesis]
GO:0048730 [epidermis morphogenesis]
GO:0048755 [branching morphogenesis of a nerve]
GO:0048762 [mesenchymal cell differentiation]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0051150 [regulation of smooth muscle cell differentiation]
GO:0051781 [positive regulation of cell division]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060076 [excitatory synapse]
GO:0060174 [limb bud formation]
GO:0060348 [bone development]
GO:0060349 [bone morphogenesis]
GO:0060442 [branching involved in prostate gland morphogenesis]
GO:0060445 [branching involved in salivary gland morphogenesis]
GO:0060449 [bud elongation involved in lung branching]
GO:0060463 [lung lobe morphogenesis]
GO:0060484 [lung-associated mesenchyme development]
GO:0060501 [positive regulation of epithelial cell proliferation involved in lung morphogenesis]
GO:0060512 [prostate gland morphogenesis]
GO:0060523 [prostate epithelial cord elongation]
GO:0060527 [prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis]
GO:0060529 [squamous basal epithelial stem cell differentiation involved in prostate gland acinus development]
GO:0060595 [fibroblast growth factor receptor signaling pathway involved in mammary gland specification]
GO:0060601 [lateral sprouting from an epithelium]
GO:0060615 [mammary gland bud formation]
GO:0060664 [epithelial cell proliferation involved in salivary gland morphogenesis]
GO:0060667 [branch elongation involved in salivary gland morphogenesis]
GO:0060670 [branching involved in labyrinthine layer morphogenesis]
GO:0060687 [regulation of branching involved in prostate gland morphogenesis]
GO:0060688 [regulation of morphogenesis of a branching structure]
GO:0060915 [mesenchymal cell differentiation involved in lung development]
GO:0060916 [mesenchymal cell proliferation involved in lung development]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
 821 aa
92 kDa 		Yes 1
FGFR2-003
ENSP00000337665
ENST00000336553
H7BXU9 [Direct mapping]
Receptor protein-tyrosine kinase
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005007 [fibroblast growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0006468 [protein phosphorylation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016021 [integral component of membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0048701 [embryonic cranial skeleton morphogenesis]
Show all
 669 aa
75.2 kDa 		Yes 1
FGFR2-004
ENSP00000353262
ENST00000360144
P21802 [Direct mapping]
Fibroblast growth factor receptor 2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001525 [angiogenesis]
GO:0001657 [ureteric bud development]
GO:0001701 [in utero embryonic development]
GO:0002053 [positive regulation of mesenchymal cell proliferation]
GO:0003148 [outflow tract septum morphogenesis]
GO:0003149 [membranous septum morphogenesis]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005007 [fibroblast growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005938 [cell cortex]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007267 [cell-cell signaling]
GO:0007409 [axonogenesis]
GO:0007411 [axon guidance]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0008589 [regulation of smoothened signaling pathway]
GO:0009791 [post-embryonic development]
GO:0009880 [embryonic pattern specification]
GO:0009887 [organ morphogenesis]
GO:0009986 [cell surface]
GO:0010453 [regulation of cell fate commitment]
GO:0010518 [positive regulation of phospholipase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016331 [morphogenesis of embryonic epithelium]
GO:0017134 [fibroblast growth factor binding]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0021769 [orbitofrontal cortex development]
GO:0021847 [ventricular zone neuroblast division]
GO:0021860 [pyramidal neuron development]
GO:0022612 [gland morphogenesis]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0030282 [bone mineralization]
GO:0030324 [lung development]
GO:0030855 [epithelial cell differentiation]
GO:0030901 [midbrain development]
GO:0030916 [otic vesicle formation]
GO:0031012 [extracellular matrix]
GO:0031069 [hair follicle morphogenesis]
GO:0032808 [lacrimal gland development]
GO:0033688 [regulation of osteoblast proliferation]
GO:0035264 [multicellular organism growth]
GO:0035265 [organ growth]
GO:0035602 [fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow]
GO:0035603 [fibroblast growth factor receptor signaling pathway involved in hemopoiesis]
GO:0035604 [fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow]
GO:0035607 [fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0040014 [regulation of multicellular organism growth]
GO:0040036 [regulation of fibroblast growth factor receptor signaling pathway]
GO:0042472 [inner ear morphogenesis]
GO:0042476 [odontogenesis]
GO:0042803 [protein homodimerization activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045087 [innate immune response]
GO:0045165 [cell fate commitment]
GO:0045667 [regulation of osteoblast differentiation]
GO:0045787 [positive regulation of cell cycle]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048286 [lung alveolus development]
GO:0048557 [embryonic digestive tract morphogenesis]
GO:0048562 [embryonic organ morphogenesis]
GO:0048565 [digestive tract development]
GO:0048568 [embryonic organ development]
GO:0048608 [reproductive structure development]
GO:0048701 [embryonic cranial skeleton morphogenesis]
GO:0048705 [skeletal system morphogenesis]
GO:0048730 [epidermis morphogenesis]
GO:0048755 [branching morphogenesis of a nerve]
GO:0048762 [mesenchymal cell differentiation]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0051150 [regulation of smooth muscle cell differentiation]
GO:0051781 [positive regulation of cell division]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060076 [excitatory synapse]
GO:0060174 [limb bud formation]
GO:0060348 [bone development]
GO:0060349 [bone morphogenesis]
GO:0060442 [branching involved in prostate gland morphogenesis]
GO:0060445 [branching involved in salivary gland morphogenesis]
GO:0060449 [bud elongation involved in lung branching]
GO:0060463 [lung lobe morphogenesis]
GO:0060484 [lung-associated mesenchyme development]
GO:0060501 [positive regulation of epithelial cell proliferation involved in lung morphogenesis]
GO:0060512 [prostate gland morphogenesis]
GO:0060523 [prostate epithelial cord elongation]
GO:0060527 [prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis]
GO:0060529 [squamous basal epithelial stem cell differentiation involved in prostate gland acinus development]
GO:0060595 [fibroblast growth factor receptor signaling pathway involved in mammary gland specification]
GO:0060601 [lateral sprouting from an epithelium]
GO:0060615 [mammary gland bud formation]
GO:0060664 [epithelial cell proliferation involved in salivary gland morphogenesis]
GO:0060667 [branch elongation involved in salivary gland morphogenesis]
GO:0060670 [branching involved in labyrinthine layer morphogenesis]
GO:0060687 [regulation of branching involved in prostate gland morphogenesis]
GO:0060688 [regulation of morphogenesis of a branching structure]
GO:0060915 [mesenchymal cell differentiation involved in lung development]
GO:0060916 [mesenchymal cell proliferation involved in lung development]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
 680 aa
76.4 kDa 		Yes 1
FGFR2-005
ENSP00000358056
ENST00000369060
P21802 [Direct mapping]
Fibroblast growth factor receptor 2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001525 [angiogenesis]
GO:0001657 [ureteric bud development]
GO:0001701 [in utero embryonic development]
GO:0002053 [positive regulation of mesenchymal cell proliferation]
GO:0003148 [outflow tract septum morphogenesis]
GO:0003149 [membranous septum morphogenesis]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005007 [fibroblast growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005938 [cell cortex]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007267 [cell-cell signaling]
GO:0007409 [axonogenesis]
GO:0007411 [axon guidance]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0008589 [regulation of smoothened signaling pathway]
GO:0009791 [post-embryonic development]
GO:0009880 [embryonic pattern specification]
GO:0009887 [organ morphogenesis]
GO:0009986 [cell surface]
GO:0010453 [regulation of cell fate commitment]
GO:0010518 [positive regulation of phospholipase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016331 [morphogenesis of embryonic epithelium]
GO:0017134 [fibroblast growth factor binding]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0021769 [orbitofrontal cortex development]
GO:0021847 [ventricular zone neuroblast division]
GO:0021860 [pyramidal neuron development]
GO:0022612 [gland morphogenesis]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0030282 [bone mineralization]
GO:0030324 [lung development]
GO:0030855 [epithelial cell differentiation]
GO:0030901 [midbrain development]
GO:0030916 [otic vesicle formation]
GO:0031012 [extracellular matrix]
GO:0031069 [hair follicle morphogenesis]
GO:0032808 [lacrimal gland development]
GO:0033688 [regulation of osteoblast proliferation]
GO:0035264 [multicellular organism growth]
GO:0035265 [organ growth]
GO:0035602 [fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow]
GO:0035603 [fibroblast growth factor receptor signaling pathway involved in hemopoiesis]
GO:0035604 [fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow]
GO:0035607 [fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0040014 [regulation of multicellular organism growth]
GO:0040036 [regulation of fibroblast growth factor receptor signaling pathway]
GO:0042472 [inner ear morphogenesis]
GO:0042476 [odontogenesis]
GO:0042803 [protein homodimerization activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045087 [innate immune response]
GO:0045165 [cell fate commitment]
GO:0045667 [regulation of osteoblast differentiation]
GO:0045787 [positive regulation of cell cycle]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048286 [lung alveolus development]
GO:0048557 [embryonic digestive tract morphogenesis]
GO:0048562 [embryonic organ morphogenesis]
GO:0048565 [digestive tract development]
GO:0048568 [embryonic organ development]
GO:0048608 [reproductive structure development]
GO:0048701 [embryonic cranial skeleton morphogenesis]
GO:0048705 [skeletal system morphogenesis]
GO:0048730 [epidermis morphogenesis]
GO:0048755 [branching morphogenesis of a nerve]
GO:0048762 [mesenchymal cell differentiation]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0051150 [regulation of smooth muscle cell differentiation]
GO:0051781 [positive regulation of cell division]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060076 [excitatory synapse]
GO:0060174 [limb bud formation]
GO:0060348 [bone development]
GO:0060349 [bone morphogenesis]
GO:0060442 [branching involved in prostate gland morphogenesis]
GO:0060445 [branching involved in salivary gland morphogenesis]
GO:0060449 [bud elongation involved in lung branching]
GO:0060463 [lung lobe morphogenesis]
GO:0060484 [lung-associated mesenchyme development]
GO:0060501 [positive regulation of epithelial cell proliferation involved in lung morphogenesis]
GO:0060512 [prostate gland morphogenesis]
GO:0060523 [prostate epithelial cord elongation]
GO:0060527 [prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis]
GO:0060529 [squamous basal epithelial stem cell differentiation involved in prostate gland acinus development]
GO:0060595 [fibroblast growth factor receptor signaling pathway involved in mammary gland specification]
GO:0060601 [lateral sprouting from an epithelium]
GO:0060615 [mammary gland bud formation]
GO:0060664 [epithelial cell proliferation involved in salivary gland morphogenesis]
GO:0060667 [branch elongation involved in salivary gland morphogenesis]
GO:0060670 [branching involved in labyrinthine layer morphogenesis]
GO:0060687 [regulation of branching involved in prostate gland morphogenesis]
GO:0060688 [regulation of morphogenesis of a branching structure]
GO:0060915 [mesenchymal cell differentiation involved in lung development]
GO:0060916 [mesenchymal cell proliferation involved in lung development]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
 705 aa
79.2 kDa 		Yes 0
FGFR2-006
ENSP00000358052
ENST00000369056
P21802 [Direct mapping]
Fibroblast growth factor receptor 2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001525 [angiogenesis]
GO:0001657 [ureteric bud development]
GO:0001701 [in utero embryonic development]
GO:0002053 [positive regulation of mesenchymal cell proliferation]
GO:0003148 [outflow tract septum morphogenesis]
GO:0003149 [membranous septum morphogenesis]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005007 [fibroblast growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005938 [cell cortex]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007267 [cell-cell signaling]
GO:0007409 [axonogenesis]
GO:0007411 [axon guidance]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0008589 [regulation of smoothened signaling pathway]
GO:0009791 [post-embryonic development]
GO:0009880 [embryonic pattern specification]
GO:0009887 [organ morphogenesis]
GO:0009986 [cell surface]
GO:0010453 [regulation of cell fate commitment]
GO:0010518 [positive regulation of phospholipase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016331 [morphogenesis of embryonic epithelium]
GO:0017134 [fibroblast growth factor binding]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0021769 [orbitofrontal cortex development]
GO:0021847 [ventricular zone neuroblast division]
GO:0021860 [pyramidal neuron development]
GO:0022612 [gland morphogenesis]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0030282 [bone mineralization]
GO:0030324 [lung development]
GO:0030855 [epithelial cell differentiation]
GO:0030901 [midbrain development]
GO:0030916 [otic vesicle formation]
GO:0031012 [extracellular matrix]
GO:0031069 [hair follicle morphogenesis]
GO:0032808 [lacrimal gland development]
GO:0033688 [regulation of osteoblast proliferation]
GO:0035264 [multicellular organism growth]
GO:0035265 [organ growth]
GO:0035602 [fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow]
GO:0035603 [fibroblast growth factor receptor signaling pathway involved in hemopoiesis]
GO:0035604 [fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow]
GO:0035607 [fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0040014 [regulation of multicellular organism growth]
GO:0040036 [regulation of fibroblast growth factor receptor signaling pathway]
GO:0042472 [inner ear morphogenesis]
GO:0042476 [odontogenesis]
GO:0042803 [protein homodimerization activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045087 [innate immune response]
GO:0045165 [cell fate commitment]
GO:0045667 [regulation of osteoblast differentiation]
GO:0045787 [positive regulation of cell cycle]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048286 [lung alveolus development]
GO:0048557 [embryonic digestive tract morphogenesis]
GO:0048562 [embryonic organ morphogenesis]
GO:0048565 [digestive tract development]
GO:0048568 [embryonic organ development]
GO:0048608 [reproductive structure development]
GO:0048701 [embryonic cranial skeleton morphogenesis]
GO:0048705 [skeletal system morphogenesis]
GO:0048730 [epidermis morphogenesis]
GO:0048755 [branching morphogenesis of a nerve]
GO:0048762 [mesenchymal cell differentiation]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0051150 [regulation of smooth muscle cell differentiation]
GO:0051781 [positive regulation of cell division]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060076 [excitatory synapse]
GO:0060174 [limb bud formation]
GO:0060348 [bone development]
GO:0060349 [bone morphogenesis]
GO:0060442 [branching involved in prostate gland morphogenesis]
GO:0060445 [branching involved in salivary gland morphogenesis]
GO:0060449 [bud elongation involved in lung branching]
GO:0060463 [lung lobe morphogenesis]
GO:0060484 [lung-associated mesenchyme development]
GO:0060501 [positive regulation of epithelial cell proliferation involved in lung morphogenesis]
GO:0060512 [prostate gland morphogenesis]
GO:0060523 [prostate epithelial cord elongation]
GO:0060527 [prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis]
GO:0060529 [squamous basal epithelial stem cell differentiation involved in prostate gland acinus development]
GO:0060595 [fibroblast growth factor receptor signaling pathway involved in mammary gland specification]
GO:0060601 [lateral sprouting from an epithelium]
GO:0060615 [mammary gland bud formation]
GO:0060664 [epithelial cell proliferation involved in salivary gland morphogenesis]
GO:0060667 [branch elongation involved in salivary gland morphogenesis]
GO:0060670 [branching involved in labyrinthine layer morphogenesis]
GO:0060687 [regulation of branching involved in prostate gland morphogenesis]
GO:0060688 [regulation of morphogenesis of a branching structure]
GO:0060915 [mesenchymal cell differentiation involved in lung development]
GO:0060916 [mesenchymal cell proliferation involved in lung development]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
 769 aa
86.2 kDa 		Yes 1
FGFR2-007
ENSP00000358055
ENST00000369059
E7EVR7 [Direct mapping]
Fibroblast growth factor receptor
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005007 [fibroblast growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016021 [integral component of membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0048701 [embryonic cranial skeleton morphogenesis]
Show all
 707 aa
79.5 kDa 		Yes 1
FGFR2-008
ENSP00000474011
ENST00000478859
S4R381 [Direct mapping]
Receptor protein-tyrosine kinase
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005007 [fibroblast growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016021 [integral component of membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0048701 [embryonic cranial skeleton morphogenesis]
Show all
 593 aa
66.7 kDa 		No 1
FGFR2-009
ENSP00000263451
ENST00000346997
P21802 [Direct mapping]
Fibroblast growth factor receptor 2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001525 [angiogenesis]
GO:0001657 [ureteric bud development]
GO:0001701 [in utero embryonic development]
GO:0002053 [positive regulation of mesenchymal cell proliferation]
GO:0003148 [outflow tract septum morphogenesis]
GO:0003149 [membranous septum morphogenesis]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005007 [fibroblast growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005938 [cell cortex]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007267 [cell-cell signaling]
GO:0007409 [axonogenesis]
GO:0007411 [axon guidance]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0008589 [regulation of smoothened signaling pathway]
GO:0009791 [post-embryonic development]
GO:0009880 [embryonic pattern specification]
GO:0009887 [organ morphogenesis]
GO:0009986 [cell surface]
GO:0010453 [regulation of cell fate commitment]
GO:0010518 [positive regulation of phospholipase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016331 [morphogenesis of embryonic epithelium]
GO:0017134 [fibroblast growth factor binding]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0021769 [orbitofrontal cortex development]
GO:0021847 [ventricular zone neuroblast division]
GO:0021860 [pyramidal neuron development]
GO:0022612 [gland morphogenesis]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0030282 [bone mineralization]
GO:0030324 [lung development]
GO:0030855 [epithelial cell differentiation]
GO:0030901 [midbrain development]
GO:0030916 [otic vesicle formation]
GO:0031012 [extracellular matrix]
GO:0031069 [hair follicle morphogenesis]
GO:0032808 [lacrimal gland development]
GO:0033688 [regulation of osteoblast proliferation]
GO:0035264 [multicellular organism growth]
GO:0035265 [organ growth]
GO:0035602 [fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow]
GO:0035603 [fibroblast growth factor receptor signaling pathway involved in hemopoiesis]
GO:0035604 [fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow]
GO:0035607 [fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0040014 [regulation of multicellular organism growth]
GO:0040036 [regulation of fibroblast growth factor receptor signaling pathway]
GO:0042472 [inner ear morphogenesis]
GO:0042476 [odontogenesis]
GO:0042803 [protein homodimerization activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045087 [innate immune response]
GO:0045165 [cell fate commitment]
GO:0045667 [regulation of osteoblast differentiation]
GO:0045787 [positive regulation of cell cycle]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048286 [lung alveolus development]
GO:0048557 [embryonic digestive tract morphogenesis]
GO:0048562 [embryonic organ morphogenesis]
GO:0048565 [digestive tract development]
GO:0048568 [embryonic organ development]
GO:0048608 [reproductive structure development]
GO:0048701 [embryonic cranial skeleton morphogenesis]
GO:0048705 [skeletal system morphogenesis]
GO:0048730 [epidermis morphogenesis]
GO:0048755 [branching morphogenesis of a nerve]
GO:0048762 [mesenchymal cell differentiation]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0051150 [regulation of smooth muscle cell differentiation]
GO:0051781 [positive regulation of cell division]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060076 [excitatory synapse]
GO:0060174 [limb bud formation]
GO:0060348 [bone development]
GO:0060349 [bone morphogenesis]
GO:0060442 [branching involved in prostate gland morphogenesis]
GO:0060445 [branching involved in salivary gland morphogenesis]
GO:0060449 [bud elongation involved in lung branching]
GO:0060463 [lung lobe morphogenesis]
GO:0060484 [lung-associated mesenchyme development]
GO:0060501 [positive regulation of epithelial cell proliferation involved in lung morphogenesis]
GO:0060512 [prostate gland morphogenesis]
GO:0060523 [prostate epithelial cord elongation]
GO:0060527 [prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis]
GO:0060529 [squamous basal epithelial stem cell differentiation involved in prostate gland acinus development]
GO:0060595 [fibroblast growth factor receptor signaling pathway involved in mammary gland specification]
GO:0060601 [lateral sprouting from an epithelium]
GO:0060615 [mammary gland bud formation]
GO:0060664 [epithelial cell proliferation involved in salivary gland morphogenesis]
GO:0060667 [branch elongation involved in salivary gland morphogenesis]
GO:0060670 [branching involved in labyrinthine layer morphogenesis]
GO:0060687 [regulation of branching involved in prostate gland morphogenesis]
GO:0060688 [regulation of morphogenesis of a branching structure]
GO:0060915 [mesenchymal cell differentiation involved in lung development]
GO:0060916 [mesenchymal cell proliferation involved in lung development]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
 819 aa
91.8 kDa 		Yes 1
FGFR2-010
ENSP00000410294
ENST00000457416
P21802 [Direct mapping]
Fibroblast growth factor receptor 2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001525 [angiogenesis]
GO:0001657 [ureteric bud development]
GO:0001701 [in utero embryonic development]
GO:0001837 [epithelial to mesenchymal transition]
GO:0002053 [positive regulation of mesenchymal cell proliferation]
GO:0003148 [outflow tract septum morphogenesis]
GO:0003149 [membranous septum morphogenesis]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005007 [fibroblast growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005938 [cell cortex]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007267 [cell-cell signaling]
GO:0007409 [axonogenesis]
GO:0007411 [axon guidance]
GO:0007528 [neuromuscular junction development]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0008589 [regulation of smoothened signaling pathway]
GO:0009791 [post-embryonic development]
GO:0009880 [embryonic pattern specification]
GO:0009887 [organ morphogenesis]
GO:0009986 [cell surface]
GO:0010453 [regulation of cell fate commitment]
GO:0010518 [positive regulation of phospholipase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016331 [morphogenesis of embryonic epithelium]
GO:0017134 [fibroblast growth factor binding]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0021769 [orbitofrontal cortex development]
GO:0021847 [ventricular zone neuroblast division]
GO:0021860 [pyramidal neuron development]
GO:0022612 [gland morphogenesis]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0030282 [bone mineralization]
GO:0030324 [lung development]
GO:0030855 [epithelial cell differentiation]
GO:0030901 [midbrain development]
GO:0030916 [otic vesicle formation]
GO:0031012 [extracellular matrix]
GO:0031069 [hair follicle morphogenesis]
GO:0032808 [lacrimal gland development]
GO:0033688 [regulation of osteoblast proliferation]
GO:0035264 [multicellular organism growth]
GO:0035265 [organ growth]
GO:0035602 [fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow]
GO:0035603 [fibroblast growth factor receptor signaling pathway involved in hemopoiesis]
GO:0035604 [fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow]
GO:0035607 [fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0040014 [regulation of multicellular organism growth]
GO:0040036 [regulation of fibroblast growth factor receptor signaling pathway]
GO:0042127 [regulation of cell proliferation]
GO:0042472 [inner ear morphogenesis]
GO:0042476 [odontogenesis]
GO:0042803 [protein homodimerization activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045087 [innate immune response]
GO:0045165 [cell fate commitment]
GO:0045667 [regulation of osteoblast differentiation]
GO:0045787 [positive regulation of cell cycle]
GO:0045839 [negative regulation of mitotic nuclear division]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048286 [lung alveolus development]
GO:0048333 [mesodermal cell differentiation]
GO:0048489 [synaptic vesicle transport]
GO:0048557 [embryonic digestive tract morphogenesis]
GO:0048562 [embryonic organ morphogenesis]
GO:0048565 [digestive tract development]
GO:0048568 [embryonic organ development]
GO:0048608 [reproductive structure development]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0048701 [embryonic cranial skeleton morphogenesis]
GO:0048705 [skeletal system morphogenesis]
GO:0048730 [epidermis morphogenesis]
GO:0048755 [branching morphogenesis of a nerve]
GO:0048762 [mesenchymal cell differentiation]
GO:0050673 [epithelial cell proliferation]
GO:0050678 [regulation of epithelial cell proliferation]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0051150 [regulation of smooth muscle cell differentiation]
GO:0051781 [positive regulation of cell division]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060076 [excitatory synapse]
GO:0060174 [limb bud formation]
GO:0060348 [bone development]
GO:0060349 [bone morphogenesis]
GO:0060365 [coronal suture morphogenesis]
GO:0060441 [epithelial tube branching involved in lung morphogenesis]
GO:0060442 [branching involved in prostate gland morphogenesis]
GO:0060445 [branching involved in salivary gland morphogenesis]
GO:0060449 [bud elongation involved in lung branching]
GO:0060463 [lung lobe morphogenesis]
GO:0060484 [lung-associated mesenchyme development]
GO:0060501 [positive regulation of epithelial cell proliferation involved in lung morphogenesis]
GO:0060512 [prostate gland morphogenesis]
GO:0060523 [prostate epithelial cord elongation]
GO:0060527 [prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis]
GO:0060529 [squamous basal epithelial stem cell differentiation involved in prostate gland acinus development]
GO:0060595 [fibroblast growth factor receptor signaling pathway involved in mammary gland specification]
GO:0060601 [lateral sprouting from an epithelium]
GO:0060615 [mammary gland bud formation]
GO:0060664 [epithelial cell proliferation involved in salivary gland morphogenesis]
GO:0060667 [branch elongation involved in salivary gland morphogenesis]
GO:0060670 [branching involved in labyrinthine layer morphogenesis]
GO:0060687 [regulation of branching involved in prostate gland morphogenesis]
GO:0060688 [regulation of morphogenesis of a branching structure]
GO:0060915 [mesenchymal cell differentiation involved in lung development]
GO:0060916 [mesenchymal cell proliferation involved in lung development]
GO:0061031 [endodermal digestive tract morphogenesis]
GO:0070307 [lens fiber cell development]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
 822 aa
92.1 kDa 		Yes 1
FGFR2-011
ENSP00000358054
ENST00000369058
P21802 [Direct mapping]
Fibroblast growth factor receptor 2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001525 [angiogenesis]
GO:0001657 [ureteric bud development]
GO:0001701 [in utero embryonic development]
GO:0002053 [positive regulation of mesenchymal cell proliferation]
GO:0003148 [outflow tract septum morphogenesis]
GO:0003149 [membranous septum morphogenesis]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005007 [fibroblast growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005938 [cell cortex]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007267 [cell-cell signaling]
GO:0007409 [axonogenesis]
GO:0007411 [axon guidance]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0008589 [regulation of smoothened signaling pathway]
GO:0009791 [post-embryonic development]
GO:0009880 [embryonic pattern specification]
GO:0009887 [organ morphogenesis]
GO:0009986 [cell surface]
GO:0010453 [regulation of cell fate commitment]
GO:0010518 [positive regulation of phospholipase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016331 [morphogenesis of embryonic epithelium]
GO:0017134 [fibroblast growth factor binding]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0021769 [orbitofrontal cortex development]
GO:0021847 [ventricular zone neuroblast division]
GO:0021860 [pyramidal neuron development]
GO:0022612 [gland morphogenesis]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0030282 [bone mineralization]
GO:0030324 [lung development]
GO:0030855 [epithelial cell differentiation]
GO:0030901 [midbrain development]
GO:0030916 [otic vesicle formation]
GO:0031012 [extracellular matrix]
GO:0031069 [hair follicle morphogenesis]
GO:0032808 [lacrimal gland development]
GO:0033688 [regulation of osteoblast proliferation]
GO:0035264 [multicellular organism growth]
GO:0035265 [organ growth]
GO:0035602 [fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow]
GO:0035603 [fibroblast growth factor receptor signaling pathway involved in hemopoiesis]
GO:0035604 [fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow]
GO:0035607 [fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0040014 [regulation of multicellular organism growth]
GO:0040036 [regulation of fibroblast growth factor receptor signaling pathway]
GO:0042472 [inner ear morphogenesis]
GO:0042476 [odontogenesis]
GO:0042803 [protein homodimerization activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045087 [innate immune response]
GO:0045165 [cell fate commitment]
GO:0045667 [regulation of osteoblast differentiation]
GO:0045787 [positive regulation of cell cycle]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048286 [lung alveolus development]
GO:0048557 [embryonic digestive tract morphogenesis]
GO:0048562 [embryonic organ morphogenesis]
GO:0048565 [digestive tract development]
GO:0048568 [embryonic organ development]
GO:0048608 [reproductive structure development]
GO:0048701 [embryonic cranial skeleton morphogenesis]
GO:0048705 [skeletal system morphogenesis]
GO:0048730 [epidermis morphogenesis]
GO:0048755 [branching morphogenesis of a nerve]
GO:0048762 [mesenchymal cell differentiation]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0051150 [regulation of smooth muscle cell differentiation]
GO:0051781 [positive regulation of cell division]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060076 [excitatory synapse]
GO:0060174 [limb bud formation]
GO:0060348 [bone development]
GO:0060349 [bone morphogenesis]
GO:0060442 [branching involved in prostate gland morphogenesis]
GO:0060445 [branching involved in salivary gland morphogenesis]
GO:0060449 [bud elongation involved in lung branching]
GO:0060463 [lung lobe morphogenesis]
GO:0060484 [lung-associated mesenchyme development]
GO:0060501 [positive regulation of epithelial cell proliferation involved in lung morphogenesis]
GO:0060512 [prostate gland morphogenesis]
GO:0060523 [prostate epithelial cord elongation]
GO:0060527 [prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis]
GO:0060529 [squamous basal epithelial stem cell differentiation involved in prostate gland acinus development]
GO:0060595 [fibroblast growth factor receptor signaling pathway involved in mammary gland specification]
GO:0060601 [lateral sprouting from an epithelium]
GO:0060615 [mammary gland bud formation]
GO:0060664 [epithelial cell proliferation involved in salivary gland morphogenesis]
GO:0060667 [branch elongation involved in salivary gland morphogenesis]
GO:0060670 [branching involved in labyrinthine layer morphogenesis]
GO:0060687 [regulation of branching involved in prostate gland morphogenesis]
GO:0060688 [regulation of morphogenesis of a branching structure]
GO:0060915 [mesenchymal cell differentiation involved in lung development]
GO:0060916 [mesenchymal cell proliferation involved in lung development]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
 768 aa
86.1 kDa 		Yes 1
FGFR2-012
ENSP00000348559
ENST00000356226
P21802 [Direct mapping]
Fibroblast growth factor receptor 2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001525 [angiogenesis]
GO:0001657 [ureteric bud development]
GO:0001701 [in utero embryonic development]
GO:0002053 [positive regulation of mesenchymal cell proliferation]
GO:0003148 [outflow tract septum morphogenesis]
GO:0003149 [membranous septum morphogenesis]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005007 [fibroblast growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005938 [cell cortex]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007267 [cell-cell signaling]
GO:0007409 [axonogenesis]
GO:0007411 [axon guidance]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0008589 [regulation of smoothened signaling pathway]
GO:0009791 [post-embryonic development]
GO:0009880 [embryonic pattern specification]
GO:0009887 [organ morphogenesis]
GO:0009986 [cell surface]
GO:0010453 [regulation of cell fate commitment]
GO:0010518 [positive regulation of phospholipase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016331 [morphogenesis of embryonic epithelium]
GO:0017134 [fibroblast growth factor binding]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0021769 [orbitofrontal cortex development]
GO:0021847 [ventricular zone neuroblast division]
GO:0021860 [pyramidal neuron development]
GO:0022612 [gland morphogenesis]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0030282 [bone mineralization]
GO:0030324 [lung development]
GO:0030855 [epithelial cell differentiation]
GO:0030901 [midbrain development]
GO:0030916 [otic vesicle formation]
GO:0031012 [extracellular matrix]
GO:0031069 [hair follicle morphogenesis]
GO:0032808 [lacrimal gland development]
GO:0033688 [regulation of osteoblast proliferation]
GO:0035264 [multicellular organism growth]
GO:0035265 [organ growth]
GO:0035602 [fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow]
GO:0035603 [fibroblast growth factor receptor signaling pathway involved in hemopoiesis]
GO:0035604 [fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow]
GO:0035607 [fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0040014 [regulation of multicellular organism growth]
GO:0040036 [regulation of fibroblast growth factor receptor signaling pathway]
GO:0042472 [inner ear morphogenesis]
GO:0042476 [odontogenesis]
GO:0042803 [protein homodimerization activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045087 [innate immune response]
GO:0045165 [cell fate commitment]
GO:0045667 [regulation of osteoblast differentiation]
GO:0045787 [positive regulation of cell cycle]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048286 [lung alveolus development]
GO:0048557 [embryonic digestive tract morphogenesis]
GO:0048562 [embryonic organ morphogenesis]
GO:0048565 [digestive tract development]
GO:0048568 [embryonic organ development]
GO:0048608 [reproductive structure development]
GO:0048701 [embryonic cranial skeleton morphogenesis]
GO:0048705 [skeletal system morphogenesis]
GO:0048730 [epidermis morphogenesis]
GO:0048755 [branching morphogenesis of a nerve]
GO:0048762 [mesenchymal cell differentiation]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0051150 [regulation of smooth muscle cell differentiation]
GO:0051781 [positive regulation of cell division]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060076 [excitatory synapse]
GO:0060174 [limb bud formation]
GO:0060348 [bone development]
GO:0060349 [bone morphogenesis]
GO:0060442 [branching involved in prostate gland morphogenesis]
GO:0060445 [branching involved in salivary gland morphogenesis]
GO:0060449 [bud elongation involved in lung branching]
GO:0060463 [lung lobe morphogenesis]
GO:0060484 [lung-associated mesenchyme development]
GO:0060501 [positive regulation of epithelial cell proliferation involved in lung morphogenesis]
GO:0060512 [prostate gland morphogenesis]
GO:0060523 [prostate epithelial cord elongation]
GO:0060527 [prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis]
GO:0060529 [squamous basal epithelial stem cell differentiation involved in prostate gland acinus development]
GO:0060595 [fibroblast growth factor receptor signaling pathway involved in mammary gland specification]
GO:0060601 [lateral sprouting from an epithelium]
GO:0060615 [mammary gland bud formation]
GO:0060664 [epithelial cell proliferation involved in salivary gland morphogenesis]
GO:0060667 [branch elongation involved in salivary gland morphogenesis]
GO:0060670 [branching involved in labyrinthine layer morphogenesis]
GO:0060687 [regulation of branching involved in prostate gland morphogenesis]
GO:0060688 [regulation of morphogenesis of a branching structure]
GO:0060915 [mesenchymal cell differentiation involved in lung development]
GO:0060916 [mesenchymal cell proliferation involved in lung development]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
 704 aa
79.2 kDa 		Yes 1
FGFR2-016
ENSP00000352309
ENST00000359354
P21802 [Direct mapping]
Fibroblast growth factor receptor 2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001525 [angiogenesis]
GO:0001657 [ureteric bud development]
GO:0001701 [in utero embryonic development]
GO:0002053 [positive regulation of mesenchymal cell proliferation]
GO:0003148 [outflow tract septum morphogenesis]
GO:0003149 [membranous septum morphogenesis]
GO:0004713 [protein tyrosine kinase activity]
GO:0005007 [fibroblast growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005938 [cell cortex]
GO:0006915 [apoptotic process]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007267 [cell-cell signaling]
GO:0007409 [axonogenesis]
GO:0007411 [axon guidance]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0008589 [regulation of smoothened signaling pathway]
GO:0009791 [post-embryonic development]
GO:0009880 [embryonic pattern specification]
GO:0009887 [organ morphogenesis]
GO:0009986 [cell surface]
GO:0010453 [regulation of cell fate commitment]
GO:0010518 [positive regulation of phospholipase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016331 [morphogenesis of embryonic epithelium]
GO:0017134 [fibroblast growth factor binding]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0021769 [orbitofrontal cortex development]
GO:0021847 [ventricular zone neuroblast division]
GO:0021860 [pyramidal neuron development]
GO:0022612 [gland morphogenesis]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0030282 [bone mineralization]
GO:0030324 [lung development]
GO:0030855 [epithelial cell differentiation]
GO:0030901 [midbrain development]
GO:0030916 [otic vesicle formation]
GO:0031012 [extracellular matrix]
GO:0031069 [hair follicle morphogenesis]
GO:0032808 [lacrimal gland development]
GO:0033688 [regulation of osteoblast proliferation]
GO:0035264 [multicellular organism growth]
GO:0035265 [organ growth]
GO:0035602 [fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow]
GO:0035603 [fibroblast growth factor receptor signaling pathway involved in hemopoiesis]
GO:0035604 [fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow]
GO:0035607 [fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0040014 [regulation of multicellular organism growth]
GO:0040036 [regulation of fibroblast growth factor receptor signaling pathway]
GO:0042472 [inner ear morphogenesis]
GO:0042476 [odontogenesis]
GO:0042803 [protein homodimerization activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045087 [innate immune response]
GO:0045165 [cell fate commitment]
GO:0045667 [regulation of osteoblast differentiation]
GO:0045787 [positive regulation of cell cycle]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048286 [lung alveolus development]
GO:0048557 [embryonic digestive tract morphogenesis]
GO:0048562 [embryonic organ morphogenesis]
GO:0048565 [digestive tract development]
GO:0048568 [embryonic organ development]
GO:0048608 [reproductive structure development]
GO:0048701 [embryonic cranial skeleton morphogenesis]
GO:0048705 [skeletal system morphogenesis]
GO:0048730 [epidermis morphogenesis]
GO:0048755 [branching morphogenesis of a nerve]
GO:0048762 [mesenchymal cell differentiation]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0051150 [regulation of smooth muscle cell differentiation]
GO:0051781 [positive regulation of cell division]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060076 [excitatory synapse]
GO:0060174 [limb bud formation]
GO:0060348 [bone development]
GO:0060349 [bone morphogenesis]
GO:0060442 [branching involved in prostate gland morphogenesis]
GO:0060445 [branching involved in salivary gland morphogenesis]
GO:0060449 [bud elongation involved in lung branching]
GO:0060463 [lung lobe morphogenesis]
GO:0060484 [lung-associated mesenchyme development]
GO:0060501 [positive regulation of epithelial cell proliferation involved in lung morphogenesis]
GO:0060512 [prostate gland morphogenesis]
GO:0060523 [prostate epithelial cord elongation]
GO:0060527 [prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis]
GO:0060529 [squamous basal epithelial stem cell differentiation involved in prostate gland acinus development]
GO:0060595 [fibroblast growth factor receptor signaling pathway involved in mammary gland specification]
GO:0060601 [lateral sprouting from an epithelium]
GO:0060615 [mammary gland bud formation]
GO:0060664 [epithelial cell proliferation involved in salivary gland morphogenesis]
GO:0060667 [branch elongation involved in salivary gland morphogenesis]
GO:0060670 [branching involved in labyrinthine layer morphogenesis]
GO:0060687 [regulation of branching involved in prostate gland morphogenesis]
GO:0060688 [regulation of morphogenesis of a branching structure]
GO:0060915 [mesenchymal cell differentiation involved in lung development]
GO:0060916 [mesenchymal cell proliferation involved in lung development]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
 254 aa
28.3 kDa 		Yes 0
FGFR2-021
ENSP00000404219
ENST00000429361
H7C265 [Direct mapping]
Fibroblast growth factor receptor 2
Show all
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005007 [fibroblast growth factor-activated receptor activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0048701 [embryonic cranial skeleton morphogenesis]
Show all
 371 aa
41.9 kDa 		No 0
FGFR2-025
ENSP00000481464
ENST00000613324
A0A087WY21 [Direct mapping]
Fibroblast growth factor receptor 2
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005007 [fibroblast growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0048701 [embryonic cranial skeleton morphogenesis]
Show all
 136 aa
14.7 kDa 		No 0
FGFR2-026
ENSP00000484892
ENST00000611527
A0A087X2D1 [Direct mapping]
Fibroblast growth factor receptor 2
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
 64 aa
6.9 kDa 		Yes 0
FGFR2-201
ENSP00000309878
ENST00000351936
A0A0A0MR25 [Direct mapping]
Fibroblast growth factor receptor
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005007 [fibroblast growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016021 [integral component of membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0048701 [embryonic cranial skeleton morphogenesis]
Show all
 821 aa
92.1 kDa 		Yes 1
FGFR2-202
ENSP00000350166
ENST00000357555
P21802 [Direct mapping]
Fibroblast growth factor receptor 2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001525 [angiogenesis]
GO:0001657 [ureteric bud development]
GO:0001701 [in utero embryonic development]
GO:0002053 [positive regulation of mesenchymal cell proliferation]
GO:0003148 [outflow tract septum morphogenesis]
GO:0003149 [membranous septum morphogenesis]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005007 [fibroblast growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005938 [cell cortex]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007267 [cell-cell signaling]
GO:0007409 [axonogenesis]
GO:0007411 [axon guidance]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0008589 [regulation of smoothened signaling pathway]
GO:0009791 [post-embryonic development]
GO:0009880 [embryonic pattern specification]
GO:0009887 [organ morphogenesis]
GO:0009986 [cell surface]
GO:0010453 [regulation of cell fate commitment]
GO:0010518 [positive regulation of phospholipase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016331 [morphogenesis of embryonic epithelium]
GO:0017134 [fibroblast growth factor binding]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0021769 [orbitofrontal cortex development]
GO:0021847 [ventricular zone neuroblast division]
GO:0021860 [pyramidal neuron development]
GO:0022612 [gland morphogenesis]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0030282 [bone mineralization]
GO:0030324 [lung development]
GO:0030855 [epithelial cell differentiation]
GO:0030901 [midbrain development]
GO:0030916 [otic vesicle formation]
GO:0031012 [extracellular matrix]
GO:0031069 [hair follicle morphogenesis]
GO:0032808 [lacrimal gland development]
GO:0033688 [regulation of osteoblast proliferation]
GO:0035264 [multicellular organism growth]
GO:0035265 [organ growth]
GO:0035602 [fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow]
GO:0035603 [fibroblast growth factor receptor signaling pathway involved in hemopoiesis]
GO:0035604 [fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow]
GO:0035607 [fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0040014 [regulation of multicellular organism growth]
GO:0040036 [regulation of fibroblast growth factor receptor signaling pathway]
GO:0042472 [inner ear morphogenesis]
GO:0042476 [odontogenesis]
GO:0042803 [protein homodimerization activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045087 [innate immune response]
GO:0045165 [cell fate commitment]
GO:0045667 [regulation of osteoblast differentiation]
GO:0045787 [positive regulation of cell cycle]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048286 [lung alveolus development]
GO:0048557 [embryonic digestive tract morphogenesis]
GO:0048562 [embryonic organ morphogenesis]
GO:0048565 [digestive tract development]
GO:0048568 [embryonic organ development]
GO:0048608 [reproductive structure development]
GO:0048701 [embryonic cranial skeleton morphogenesis]
GO:0048705 [skeletal system morphogenesis]
GO:0048730 [epidermis morphogenesis]
GO:0048755 [branching morphogenesis of a nerve]
GO:0048762 [mesenchymal cell differentiation]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0051150 [regulation of smooth muscle cell differentiation]
GO:0051781 [positive regulation of cell division]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060076 [excitatory synapse]
GO:0060174 [limb bud formation]
GO:0060348 [bone development]
GO:0060349 [bone morphogenesis]
GO:0060442 [branching involved in prostate gland morphogenesis]
GO:0060445 [branching involved in salivary gland morphogenesis]
GO:0060449 [bud elongation involved in lung branching]
GO:0060463 [lung lobe morphogenesis]
GO:0060484 [lung-associated mesenchyme development]
GO:0060501 [positive regulation of epithelial cell proliferation involved in lung morphogenesis]
GO:0060512 [prostate gland morphogenesis]
GO:0060523 [prostate epithelial cord elongation]
GO:0060527 [prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis]
GO:0060529 [squamous basal epithelial stem cell differentiation involved in prostate gland acinus development]
GO:0060595 [fibroblast growth factor receptor signaling pathway involved in mammary gland specification]
GO:0060601 [lateral sprouting from an epithelium]
GO:0060615 [mammary gland bud formation]
GO:0060664 [epithelial cell proliferation involved in salivary gland morphogenesis]
GO:0060667 [branch elongation involved in salivary gland morphogenesis]
GO:0060670 [branching involved in labyrinthine layer morphogenesis]
GO:0060687 [regulation of branching involved in prostate gland morphogenesis]
GO:0060688 [regulation of morphogenesis of a branching structure]
GO:0060915 [mesenchymal cell differentiation involved in lung development]
GO:0060916 [mesenchymal cell proliferation involved in lung development]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
 707 aa
79.3 kDa 		Yes 1
FGFR2-203
ENSP00000358057
ENST00000369061
P21802 [Direct mapping]
Fibroblast growth factor receptor 2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001525 [angiogenesis]
GO:0001657 [ureteric bud development]
GO:0001701 [in utero embryonic development]
GO:0002053 [positive regulation of mesenchymal cell proliferation]
GO:0003148 [outflow tract septum morphogenesis]
GO:0003149 [membranous septum morphogenesis]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005007 [fibroblast growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005938 [cell cortex]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007267 [cell-cell signaling]
GO:0007409 [axonogenesis]
GO:0007411 [axon guidance]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0008589 [regulation of smoothened signaling pathway]
GO:0009791 [post-embryonic development]
GO:0009880 [embryonic pattern specification]
GO:0009887 [organ morphogenesis]
GO:0009986 [cell surface]
GO:0010453 [regulation of cell fate commitment]
GO:0010518 [positive regulation of phospholipase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016331 [morphogenesis of embryonic epithelium]
GO:0017134 [fibroblast growth factor binding]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0021769 [orbitofrontal cortex development]
GO:0021847 [ventricular zone neuroblast division]
GO:0021860 [pyramidal neuron development]
GO:0022612 [gland morphogenesis]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0030282 [bone mineralization]
GO:0030324 [lung development]
GO:0030855 [epithelial cell differentiation]
GO:0030901 [midbrain development]
GO:0030916 [otic vesicle formation]
GO:0031012 [extracellular matrix]
GO:0031069 [hair follicle morphogenesis]
GO:0032808 [lacrimal gland development]
GO:0033688 [regulation of osteoblast proliferation]
GO:0035264 [multicellular organism growth]
GO:0035265 [organ growth]
GO:0035602 [fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow]
GO:0035603 [fibroblast growth factor receptor signaling pathway involved in hemopoiesis]
GO:0035604 [fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow]
GO:0035607 [fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0040014 [regulation of multicellular organism growth]
GO:0040036 [regulation of fibroblast growth factor receptor signaling pathway]
GO:0042472 [inner ear morphogenesis]
GO:0042476 [odontogenesis]
GO:0042803 [protein homodimerization activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045087 [innate immune response]
GO:0045165 [cell fate commitment]
GO:0045667 [regulation of osteoblast differentiation]
GO:0045787 [positive regulation of cell cycle]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048286 [lung alveolus development]
GO:0048557 [embryonic digestive tract morphogenesis]
GO:0048562 [embryonic organ morphogenesis]
GO:0048565 [digestive tract development]
GO:0048568 [embryonic organ development]
GO:0048608 [reproductive structure development]
GO:0048701 [embryonic cranial skeleton morphogenesis]
GO:0048705 [skeletal system morphogenesis]
GO:0048730 [epidermis morphogenesis]
GO:0048755 [branching morphogenesis of a nerve]
GO:0048762 [mesenchymal cell differentiation]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0051150 [regulation of smooth muscle cell differentiation]
GO:0051781 [positive regulation of cell division]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060076 [excitatory synapse]
GO:0060174 [limb bud formation]
GO:0060348 [bone development]
GO:0060349 [bone morphogenesis]
GO:0060442 [branching involved in prostate gland morphogenesis]
GO:0060445 [branching involved in salivary gland morphogenesis]
GO:0060449 [bud elongation involved in lung branching]
GO:0060463 [lung lobe morphogenesis]
GO:0060484 [lung-associated mesenchyme development]
GO:0060501 [positive regulation of epithelial cell proliferation involved in lung morphogenesis]
GO:0060512 [prostate gland morphogenesis]
GO:0060523 [prostate epithelial cord elongation]
GO:0060527 [prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis]
GO:0060529 [squamous basal epithelial stem cell differentiation involved in prostate gland acinus development]
GO:0060595 [fibroblast growth factor receptor signaling pathway involved in mammary gland specification]
GO:0060601 [lateral sprouting from an epithelium]
GO:0060615 [mammary gland bud formation]
GO:0060664 [epithelial cell proliferation involved in salivary gland morphogenesis]
GO:0060667 [branch elongation involved in salivary gland morphogenesis]
GO:0060670 [branching involved in labyrinthine layer morphogenesis]
GO:0060687 [regulation of branching involved in prostate gland morphogenesis]
GO:0060688 [regulation of morphogenesis of a branching structure]
GO:0060915 [mesenchymal cell differentiation involved in lung development]
GO:0060916 [mesenchymal cell proliferation involved in lung development]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
 709 aa
79.8 kDa 		Yes 1
FGFR2-204
ENSP00000484154
ENST00000613048
D2CGD1 [Direct mapping]
Fibroblast growth factor receptor
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005007 [fibroblast growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016021 [integral component of membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0048701 [embryonic cranial skeleton morphogenesis]
Show all
 732 aa
82.2 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.