Expression of LRRC40 in cancer - Summary - The Human Protein Atlas

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LRRC40

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LRRC40
Gene description	Leucine rich repeat containing 40
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA026564
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (favourable).
Colorectal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA026564

GENE INFORMATION
Gene name	LRRC40 (HGNC Symbol)
Synonyms	FLJ20331
Description	Leucine rich repeat containing 40 (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	p31.1
Chromosome location (bp)	70144805 - 70205620
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000066557 (version 83.38)
Entrez gene	55631
UniProt	Q9H9A6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H9A6
Antibodypedia	LRRC40 antibodies

PROTEIN BROWSER

LRRC40-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LRRC40-001 ENSP00000359990 ENST00000370952	Q9H9A6 [Direct mapping] Leucine-rich repeat-containing protein 40 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016020 [membrane] Show all	602 aa 68.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.