Expression of ACSM2B in cancer - Summary - The Human Protein Atlas

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ACSM2B

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ACSM2B
Gene description	Acyl-CoA synthetase medium-chain family member 2B
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	11
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (liver cancer, renal cancer)
HPA (cell line):	Cell line enhanced (AF22, Hep G2)
HPA (normal tissue):	Group enriched (kidney, liver)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic expression in kidney and liver

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Supported based on 1 antibody. HPA057699
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (favourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (liver cancer, renal cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA057699

GENE INFORMATION
Gene name	ACSM2B (HGNC Symbol)
Synonyms	ACSM2, HXMA, HYST1046
Description	Acyl-CoA synthetase medium-chain family member 2B (HGNC Symbol)
Entrez gene summary
Chromosome	16
Cytoband	p12.3
Chromosome location (bp)	20536226 - 20576427
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000066813 (version 83.38)
Entrez gene	348158
UniProt	Q68CK6 (UniProt - Evidence at protein level)
neXtProt	NX_Q68CK6
Antibodypedia	ACSM2B antibodies

PROTEIN BROWSER

ACSM2B-001	ACSM2B-004	ACSM2B-006	ACSM2B-007	ACSM2B-011	ACSM2B-012	ACSM2B-014	ACSM2B-016	ACSM2B-017	ACSM2B-018	ACSM2B-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ACSM2B-001 ENSP00000327453 ENST00000329697	Q68CK6 [Direct mapping] Acyl-coenzyme A synthetase ACSM2B, mitochondrial Show all	Enzymes ENZYME proteins Ligase Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0003824 [catalytic activity] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006631 [fatty acid metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0008152 [metabolic process] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0047760 [butyrate-CoA ligase activity] Show all	577 aa 64.3 kDa	No	2
ACSM2B-004 ENSP00000457377 ENST00000565322	H3BTX9 [Direct mapping] Acyl-coenzyme A synthetase ACSM2B, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	498 aa 55.1 kDa	No	2
ACSM2B-006 ENSP00000456378 ENST00000567001	Q68CK6 [Direct mapping] Acyl-coenzyme A synthetase ACSM2B, mitochondrial Show all	Enzymes ENZYME proteins Ligase Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0003824 [catalytic activity] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006631 [fatty acid metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0008152 [metabolic process] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0047760 [butyrate-CoA ligase activity] Show all	577 aa 64.3 kDa	No	2
ACSM2B-007 ENSP00000454995 ENST00000565232	Q68CK6 [Direct mapping] Acyl-coenzyme A synthetase ACSM2B, mitochondrial Show all	Enzymes ENZYME proteins Ligase Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0003824 [catalytic activity] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006631 [fatty acid metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0008152 [metabolic process] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0047760 [butyrate-CoA ligase activity] Show all	577 aa 64.3 kDa	No	2
ACSM2B-011 ENSP00000455190 ENST00000568882	H3BP79 [Direct mapping] Acyl-coenzyme A synthetase ACSM2B, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] Show all	61 aa 6.8 kDa	No	1
ACSM2B-012 ENSP00000455658 ENST00000569344	H3BQ84 [Direct mapping] Acyl-coenzyme A synthetase ACSM2B, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		106 aa 12.1 kDa	No	0
ACSM2B-014 ENSP00000454247 ENST00000566384	H3BM61 [Direct mapping] Acyl-coenzyme A synthetase ACSM2B, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	118 aa 13.5 kDa	No	0
ACSM2B-016 ENSP00000456369 ENST00000569163	H3BRR3 [Direct mapping] Acyl-coenzyme A synthetase ACSM2B, mitochondrial Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	149 aa 16.5 kDa	No	0
ACSM2B-017 ENSP00000478316 ENST00000567288	A0A087WU25 [Direct mapping] Acyl-coenzyme A synthetase ACSM2B, mitochondrial Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	200 aa 21.9 kDa	No	0
ACSM2B-018 ENSP00000455137 ENST00000568098	H3BP39 [Direct mapping] Acyl-coenzyme A synthetase ACSM2B, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	110 aa 12.6 kDa	No	0
ACSM2B-201 ENSP00000390378 ENST00000414188	Q68CK6 [Direct mapping] Acyl-coenzyme A synthetase ACSM2B, mitochondrial Show all	Enzymes ENZYME proteins Ligase Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0003824 [catalytic activity] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006631 [fatty acid metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0008152 [metabolic process] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0047760 [butyrate-CoA ligase activity] Show all	577 aa 64.3 kDa	No	1

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The Human Protein Atlas

The Human Protein Atlas project is funded
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