Expression of NEO1 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

NEO1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NEO1
Gene description	Neogenin 1
Protein class	Cancer-related genes Plasma proteins Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 4 antibodies. HPA027804 , HPA027805 , HPA027806 , CAB009320
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA027804	HPA027805	HPA027806	CAB009320

GENE INFORMATION
Gene name	NEO1 (HGNC Symbol)
Synonyms	HsT17534, IGDCC2, NGN, NTN1R2
Description	Neogenin 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein may be involved in cell growth and differentiation and in cell-cell adhesion. Defects in this gene are associated with cell proliferation in certain cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
Chromosome	15
Cytoband	q24.1
Chromosome location (bp)	73051710 - 73305206
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000067141 (version 83.38)
Entrez gene	4756
UniProt	Q92859 (UniProt - Evidence at protein level)
neXtProt	NX_Q92859
Antibodypedia	NEO1 antibodies

PROTEIN BROWSER

NEO1-001	NEO1-002	NEO1-003	NEO1-004	NEO1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NEO1-001 ENSP00000341198 ENST00000339362	Q92859 [Direct mapping] Neogenin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006355 [regulation of transcription, DNA-templated] GO:0007155 [cell adhesion] GO:0007411 [axon guidance] GO:0007520 [myoblast fusion] GO:0016021 [integral component of membrane] GO:0030513 [positive regulation of BMP signaling pathway] GO:0039706 [co-receptor binding] GO:0042692 [muscle cell differentiation] GO:0045296 [cadherin binding] GO:0050709 [negative regulation of protein secretion] GO:0051149 [positive regulation of muscle cell differentiation] GO:0055072 [iron ion homeostasis] GO:0098797 [plasma membrane protein complex] Show all	1461 aa 160 kDa	Yes	1
NEO1-002 ENSP00000454024 ENST00000560328	Q59FP8 [Direct mapping] Neogenin; Neogenin homolog 1 variant Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	1130 aa 124 kDa	No	1
NEO1-003 ENSP00000453317 ENST00000560262	Q92859 [Direct mapping] Neogenin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007155 [cell adhesion] GO:0007411 [axon guidance] GO:0016021 [integral component of membrane] GO:0039706 [co-receptor binding] GO:0042692 [muscle cell differentiation] GO:0051149 [positive regulation of muscle cell differentiation] GO:0055072 [iron ion homeostasis] GO:0098797 [plasma membrane protein complex] Show all	1408 aa 154.3 kDa	Yes	1
NEO1-004 ENSP00000453200 ENST00000558964	Q92859 [Direct mapping] Neogenin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007155 [cell adhesion] GO:0007411 [axon guidance] GO:0016021 [integral component of membrane] GO:0039706 [co-receptor binding] GO:0042692 [muscle cell differentiation] GO:0051149 [positive regulation of muscle cell differentiation] GO:0055072 [iron ion homeostasis] GO:0098797 [plasma membrane protein complex] Show all	1450 aa 158.8 kDa	Yes	1
NEO1-201 ENSP00000261908 ENST00000261908	Q92859 [Direct mapping] Neogenin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007155 [cell adhesion] GO:0007411 [axon guidance] GO:0016021 [integral component of membrane] GO:0039706 [co-receptor binding] GO:0042692 [muscle cell differentiation] GO:0051149 [positive regulation of muscle cell differentiation] GO:0055072 [iron ion homeostasis] GO:0098797 [plasma membrane protein complex] Show all	1461 aa 160 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.