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CACNB1

GENERAL INFORMATION

Gene name

 CACNB1

Gene description

 Calcium channel, voltage-dependent, beta 1 subunit

Protein class

 FDA approved drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Mixed
HPA (normal tissue):Group enriched (cerebral cortex, skeletal muscle)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Mainly cytoplasmic expression in several tissues including neuronal cells, peripheral nerves and skeletal muscle.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Caution, Splice and/or transcript discrepancy exists.

Reliability score

 Approved based on 1 antibody.
HPA023343
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable).
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA023343

GENE INFORMATION

Gene name

 CACNB1 (HGNC Symbol)

Synonyms

 CACNLB1

Description

 Calcium channel, voltage-dependent, beta 1 subunit (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the calcium channel beta subunit family. It plays an important role in the calcium channel by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q12

Chromosome location (bp)

 39173456 - 39197703

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000067191 (version 83.38)

Entrez gene

 782

UniProt

 Q02641 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q02641

Antibodypedia

 CACNB1 antibodies

PROTEIN BROWSER
CACNB1-001
CACNB1-002
CACNB1-004
CACNB1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CACNB1-001
ENSP00000377840
ENST00000394303
Q02641 [Direct mapping]
Voltage-dependent L-type calcium channel subunit beta-1
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Predicted intracellular proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006612 [protein targeting to membrane]
GO:0006810 [transport]
GO:0006816 [calcium ion transport]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0007528 [neuromuscular junction development]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0016529 [sarcoplasmic reticulum]
GO:0019901 [protein kinase binding]
GO:0019904 [protein domain specific binding]
GO:0030315 [T-tubule]
GO:0051219 [phosphoprotein binding]
GO:0070588 [calcium ion transmembrane transport]
GO:1901385 [regulation of voltage-gated calcium channel activity]
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 598 aa
65.7 kDa 		No 0
CACNB1-002
ENSP00000345461
ENST00000344140
Q02641 [Direct mapping]
Voltage-dependent L-type calcium channel subunit beta-1
Show all
Predicted intracellular proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006810 [transport]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0007528 [neuromuscular junction development]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0070588 [calcium ion transmembrane transport]
GO:1901385 [regulation of voltage-gated calcium channel activity]
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 523 aa
57.9 kDa 		No 0
CACNB1-004
ENSP00000377847
ENST00000394310
Q02641 [Direct mapping]
Voltage-dependent L-type calcium channel subunit beta-1
Show all
Predicted intracellular proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006810 [transport]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0007528 [neuromuscular junction development]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0070588 [calcium ion transmembrane transport]
GO:1901385 [regulation of voltage-gated calcium channel activity]
Show all
 478 aa
53 kDa 		No 0
CACNB1-201
ENSP00000477612
ENST00000622445
Q6TME4 [Direct mapping]
Voltage-dependent L-type calcium channel subunit beta-1; Voltage-gated calcium channel beta 1 subunit splice variant CavB1d
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Predicted intracellular proteins
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005891 [voltage-gated calcium channel complex]
GO:0007268 [synaptic transmission]
GO:0007528 [neuromuscular junction development]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0070588 [calcium ion transmembrane transport]
GO:1901385 [regulation of voltage-gated calcium channel activity]
Show all
 216 aa
23.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.