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PKM

GENERAL INFORMATION

Gene name

 PKM

Gene description

 Pyruvate kinase, muscle

Protein class

 Cancer-related genes
Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 14
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 2 antibodies.
HPA029501 , CAB019421
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), pancreatic cancer (unfavourable), head and neck cancer (unfavourable) and lung cancer (unfavourable).
Liver cancer p<0.001
Pancreatic cancer p<0.001
Head and neck cancer p<0.001
Lung cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA029501
CAB019421

GENE INFORMATION

Gene name

 PKM (HGNC Symbol)

Synonyms

 OIP3, PK3, PKM2, THBP1

Description

 Pyruvate kinase, muscle (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported. [provided by RefSeq, May 2011]

Chromosome

 15

Cytoband

 q23

Chromosome location (bp)

 72199029 - 72231822

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000067225 (version 83.38)

Entrez gene

 5315

UniProt

 P14618 (UniProt - Evidence at protein level)

neXtProt

 NX_P14618

Antibodypedia

 PKM antibodies

PROTEIN BROWSER
«
PKM-004
PKM-006
PKM-007
PKM-008
PKM-012
PKM-016
PKM-017
PKM-018
PKM-019
PKM-020
PKM-201
PKM-202
PKM-203
PKM-204
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PKM-004
ENSP00000334983
ENST00000335181
P14618 [Direct mapping]
Pyruvate kinase PKM
V9HWB8 [Target identity:100%; Query identity:100%]
Pyruvate kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0003824 [catalytic activity]
GO:0004743 [pyruvate kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006096 [glycolytic process]
GO:0012501 [programmed cell death]
GO:0016301 [kinase activity]
GO:0023026 [MHC class II protein complex binding]
GO:0030955 [potassium ion binding]
GO:0031012 [extracellular matrix]
GO:0031982 [vesicle]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0061621 [canonical glycolysis]
GO:0070062 [extracellular exosome]
GO:1903561 [extracellular vesicle]
Show all
 531 aa
57.9 kDa 		No 0
PKM-006
ENSP00000455901
ENST00000565154
P14618 [Direct mapping]
Pyruvate kinase PKM
A0A024R5Z9 [Target identity:100%; Query identity:100%]
Pyruvate kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0003824 [catalytic activity]
GO:0004743 [pyruvate kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006096 [glycolytic process]
GO:0012501 [programmed cell death]
GO:0016301 [kinase activity]
GO:0023026 [MHC class II protein complex binding]
GO:0030955 [potassium ion binding]
GO:0031012 [extracellular matrix]
GO:0031982 [vesicle]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0061621 [canonical glycolysis]
GO:0070062 [extracellular exosome]
GO:1903561 [extracellular vesicle]
Show all
 531 aa
58.1 kDa 		No 0
PKM-007
ENSP00000456970
ENST00000568459
P14618 [Direct mapping]
Pyruvate kinase PKM
A0A024R5Z9 [Target identity:100%; Query identity:100%]
Pyruvate kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0003824 [catalytic activity]
GO:0004743 [pyruvate kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006096 [glycolytic process]
GO:0012501 [programmed cell death]
GO:0016301 [kinase activity]
GO:0023026 [MHC class II protein complex binding]
GO:0030955 [potassium ion binding]
GO:0031012 [extracellular matrix]
GO:0031982 [vesicle]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0061621 [canonical glycolysis]
GO:0070062 [extracellular exosome]
GO:1903561 [extracellular vesicle]
Show all
 531 aa
58.1 kDa 		No 0
PKM-008
ENSP00000457253
ENST00000561609
H3BTN5 [Direct mapping]
Pyruvate kinase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0003824 [catalytic activity]
GO:0004743 [pyruvate kinase activity]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006096 [glycolytic process]
GO:0016301 [kinase activity]
GO:0030955 [potassium ion binding]
Show all
 485 aa
53 kDa 		No 0
PKM-012
ENSP00000455736
ENST00000565184
P14618 [Direct mapping]
Pyruvate kinase PKM
A0A024R5Z9 [Target identity:100%; Query identity:100%]
Pyruvate kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0003824 [catalytic activity]
GO:0004743 [pyruvate kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006096 [glycolytic process]
GO:0012501 [programmed cell death]
GO:0016301 [kinase activity]
GO:0023026 [MHC class II protein complex binding]
GO:0030955 [potassium ion binding]
GO:0031012 [extracellular matrix]
GO:0031982 [vesicle]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0061621 [canonical glycolysis]
GO:0070062 [extracellular exosome]
GO:1903561 [extracellular vesicle]
Show all
 531 aa
58.1 kDa 		No 0
PKM-016
ENSP00000457198
ENST00000564178
H3BTJ2 [Direct mapping]
Pyruvate kinase PKM
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0003824 [catalytic activity]
GO:0004743 [pyruvate kinase activity]
GO:0006096 [glycolytic process]
GO:0030955 [potassium ion binding]
Show all
 168 aa
18.5 kDa 		No 0
PKM-017
ENSP00000457830
ENST00000562997
H3BUW1 [Direct mapping]
Pyruvate kinase PKM
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0003824 [catalytic activity]
GO:0004743 [pyruvate kinase activity]
GO:0006096 [glycolytic process]
GO:0030955 [potassium ion binding]
Show all
 162 aa
17.8 kDa 		No 0
PKM-018
ENSP00000454668
ENST00000569050
H3BN34 [Direct mapping]
Pyruvate kinase PKM
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004743 [pyruvate kinase activity]
GO:0006096 [glycolytic process]
GO:0030955 [potassium ion binding]
Show all
 52 aa
5.6 kDa 		No 0
PKM-019
ENSP00000457420
ENST00000566809
H3BU13 [Direct mapping]
Pyruvate kinase PKM
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0003824 [catalytic activity]
GO:0004743 [pyruvate kinase activity]
GO:0006096 [glycolytic process]
GO:0030955 [potassium ion binding]
Show all
 82 aa
9 kDa 		No 0
PKM-020
ENSP00000456984
ENST00000567087
H3BT25 [Direct mapping]
Pyruvate kinase PKM
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0003824 [catalytic activity]
GO:0004743 [pyruvate kinase activity]
GO:0006096 [glycolytic process]
GO:0030955 [potassium ion binding]
Show all
 151 aa
16.4 kDa 		No 0
PKM-201
ENSP00000320171
ENST00000319622
P14618 [Direct mapping]
Pyruvate kinase PKM
A0A024R5Z9 [Target identity:100%; Query identity:100%]
Pyruvate kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0001666 [response to hypoxia]
GO:0001889 [liver development]
GO:0003824 [catalytic activity]
GO:0004743 [pyruvate kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005929 [cilium]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006096 [glycolytic process]
GO:0006754 [ATP biosynthetic process]
GO:0007584 [response to nutrient]
GO:0009629 [response to gravity]
GO:0010033 [response to organic substance]
GO:0012501 [programmed cell death]
GO:0014870 [response to muscle inactivity]
GO:0016301 [kinase activity]
GO:0023026 [MHC class II protein complex binding]
GO:0030955 [potassium ion binding]
GO:0031012 [extracellular matrix]
GO:0031100 [organ regeneration]
GO:0031982 [vesicle]
GO:0032868 [response to insulin]
GO:0042866 [pyruvate biosynthetic process]
GO:0043209 [myelin sheath]
GO:0043403 [skeletal muscle tissue regeneration]
GO:0043531 [ADP binding]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0061621 [canonical glycolysis]
GO:0070062 [extracellular exosome]
GO:1903561 [extracellular vesicle]
Show all
 531 aa
58.1 kDa 		No 0
PKM-202
ENSP00000373745
ENST00000389093
B4DNK4 [Direct mapping]
Pyruvate kinase
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0003824 [catalytic activity]
GO:0004743 [pyruvate kinase activity]
GO:0006096 [glycolytic process]
GO:0016301 [kinase activity]
GO:0030955 [potassium ion binding]
Show all
 457 aa
49.9 kDa 		No 0
PKM-203
ENSP00000403365
ENST00000449901
P14618 [Direct mapping]
Pyruvate kinase PKM
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0003824 [catalytic activity]
GO:0004743 [pyruvate kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006096 [glycolytic process]
GO:0012501 [programmed cell death]
GO:0016301 [kinase activity]
GO:0023026 [MHC class II protein complex binding]
GO:0030955 [potassium ion binding]
GO:0031012 [extracellular matrix]
GO:0031982 [vesicle]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0061621 [canonical glycolysis]
GO:0070062 [extracellular exosome]
GO:1903561 [extracellular vesicle]
Show all
 516 aa
56.3 kDa 		No 0
PKM-204
ENSP00000456100
ENST00000568883
H3BR70 [Direct mapping]
Pyruvate kinase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0003824 [catalytic activity]
GO:0004743 [pyruvate kinase activity]
GO:0006096 [glycolytic process]
GO:0016301 [kinase activity]
GO:0030955 [potassium ion binding]
Show all
 366 aa
40.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.