Expression of METTL22 in cancer - Summary - The Human Protein Atlas

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METTL22

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	METTL22
Gene description	Methyltransferase like 22
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA040803 , HPA059882
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA040803	HPA059882

GENE INFORMATION
Gene name	METTL22 (HGNC Symbol)
Synonyms	C16orf68, FLJ12433, MGC2654
Description	Methyltransferase like 22 (HGNC Symbol)
Entrez gene summary
Chromosome	16
Cytoband	p13.2
Chromosome location (bp)	8621683 - 8649654
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000067365 (version 83.38)
Entrez gene	79091
UniProt	Q9BUU2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BUU2
Antibodypedia	METTL22 antibodies

PROTEIN BROWSER

METTL22-001	METTL22-002	METTL22-006	METTL22-007	METTL22-016	METTL22-018

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
METTL22-001 ENSP00000371345 ENST00000381920	Q9BUU2 [Direct mapping] Methyltransferase-like protein 22 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0008168 [methyltransferase activity] GO:0032259 [methylation] Show all	404 aa 44.5 kDa	No	0
METTL22-002 ENSP00000457152 ENST00000561758	H3BTF5 [Direct mapping] Methyltransferase-like protein 22 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		348 aa 38.6 kDa	No	0
METTL22-006 ENSP00000457291 ENST00000563958	H3BTR2 [Direct mapping] Methyltransferase-like protein 22 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		70 aa 7.8 kDa	No	0
METTL22-007 ENSP00000456618 ENST00000564554	H3BSA9 [Direct mapping] Methyltransferase-like protein 22 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		16 aa 1.8 kDa	No	0
METTL22-016 ENSP00000460481 ENST00000562973	I3L3I8 [Direct mapping] Methyltransferase-like protein 22 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		103 aa 11.6 kDa	No	0
METTL22-018 ENSP00000461054 ENST00000562151	I3L483 [Direct mapping] Methyltransferase-like protein 22 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		165 aa 18.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.