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TP53BP1

GENERAL INFORMATION

Gene name

 TP53BP1

Gene description

 Tumor protein p53 binding protein 1

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA008788 , HPA022133 , CAB004083
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA008788
HPA022133
CAB004083

GENE INFORMATION

Gene name

 TP53BP1 (HGNC Symbol)

Synonyms

 53BP1, p202, TDRD30

Description

 Tumor protein p53 binding protein 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 15

Cytoband

 q15.3

Chromosome location (bp)

 43403061 - 43510728

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000067369 (version 83.38)

Entrez gene

 7158

UniProt

 Q12888 (UniProt - Evidence at protein level)

neXtProt

 NX_Q12888

Antibodypedia

 TP53BP1 antibodies

PROTEIN BROWSER
TP53BP1-001
TP53BP1-002
TP53BP1-004
TP53BP1-005
TP53BP1-010
TP53BP1-013
TP53BP1-014

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TP53BP1-001
ENSP00000371475
ENST00000382044
Q12888 [Direct mapping]
Tumor suppressor p53-binding protein 1
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   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000077 [DNA damage checkpoint]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000776 [kinetochore]
GO:0000777 [condensed chromosome kinetochore]
GO:0000781 [chromosome, telomeric region]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0001104 [RNA polymerase II transcription cofactor activity]
GO:0002039 [p53 binding]
GO:0003684 [damaged DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005657 [replication fork]
GO:0005737 [cytoplasm]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0006351 [transcription, DNA-templated]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0035064 [methylated histone binding]
GO:0042162 [telomeric DNA binding]
GO:0043565 [sequence-specific DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0071481 [cellular response to X-ray]
GO:1990391 [DNA repair complex]
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 1977 aa
214.1 kDa 		No 0
TP53BP1-002
ENSP00000263801
ENST00000263801
Q12888 [Direct mapping]
Tumor suppressor p53-binding protein 1
Show all
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000077 [DNA damage checkpoint]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000777 [condensed chromosome kinetochore]
GO:0000781 [chromosome, telomeric region]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0001104 [RNA polymerase II transcription cofactor activity]
GO:0002039 [p53 binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0006351 [transcription, DNA-templated]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0035064 [methylated histone binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
Show all
 1972 aa
213.6 kDa 		No 0
TP53BP1-004
ENSP00000371470
ENST00000382039
A6NNK5 [Direct mapping]
Tumor suppressor p53-binding protein 1
Show all
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
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 1927 aa
209 kDa 		No 0
TP53BP1-005
ENSP00000388028
ENST00000413546
C9JXV0 [Direct mapping]
Tumor suppressor p53-binding protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
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 1033 aa
111.7 kDa 		No 0
TP53BP1-010
ENSP00000416212
ENST00000434595
H7C495 [Direct mapping]
Tumor suppressor p53-binding protein 1
Show all
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
 149 aa
16.4 kDa 		No 0
TP53BP1-013
ENSP00000471624
ENST00000467474
M0R142 [Direct mapping]
Tumor suppressor p53-binding protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
 144 aa
15.1 kDa 		No 0
TP53BP1-014
ENSP00000393497
ENST00000450115
Q12888 [Direct mapping]
Tumor suppressor p53-binding protein 1
Show all
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000077 [DNA damage checkpoint]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000777 [condensed chromosome kinetochore]
GO:0000781 [chromosome, telomeric region]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0001104 [RNA polymerase II transcription cofactor activity]
GO:0002039 [p53 binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0006351 [transcription, DNA-templated]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0035064 [methylated histone binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
Show all
 1975 aa
214 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.