Expression of TRO in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	TRO
Gene description	Trophinin
Protein class	Cancer-related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	18
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (AF22, SCLC-21H, SH-SY5Y)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. CAB033947
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable) and pancreatic cancer (favourable).
Endometrial cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

CAB033947

GENE INFORMATION
Gene name	TRO (HGNC Symbol)
Synonyms	KIAA1114, MAGE-D3, MAGED3
Description	Trophinin (HGNC Symbol)
Entrez gene summary	This gene encodes a membrane protein that mediates cell adhesion between trophoblastic cells and the epithelial cells of the endometrium. The encoded protein participates in cell signalling during embryo implantation, and may also be involved in cancer formation. This gene is located near several other closely related genes on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]
Chromosome	X
Cytoband	p11.21
Chromosome location (bp)	54920462 - 54931431
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000067445 (version 83.38)
Entrez gene	7216
UniProt	Q12816 (UniProt - Evidence at protein level)
neXtProt	NX_Q12816
Antibodypedia	TRO antibodies

PROTEIN BROWSER

TRO-004	TRO-006	TRO-008	TRO-009	TRO-010	TRO-011	TRO-012	TRO-013	TRO-014	TRO-015	TRO-016	TRO-017	TRO-018	TRO-019	TRO-021	TRO-024	TRO-201	TRO-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TRO-004 ENSP00000387676 ENST00000452830	B1AKF3 [Direct mapping] Trophinin Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		71 aa 7.6 kDa	No	0
TRO-006 ENSP00000405311 ENST00000427099	E7ERU6 [Direct mapping] Trophinin Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		121 aa 12.7 kDa	No	0
TRO-008 ENSP00000173898 ENST00000173898	Q12816 [Direct mapping] Trophinin Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007566 [embryo implantation] GO:0030308 [negative regulation of cell growth] Show all	1431 aa 143.7 kDa	No	0
TRO-009 ENSP00000364181 ENST00000375041	Q12816 [Direct mapping] Trophinin Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007566 [embryo implantation] Show all	1034 aa 102.3 kDa	No	0
TRO-010 ENSP00000364162 ENST00000375022	Q12816 [Direct mapping] Trophinin A0A024R9X0 [Target identity:100%; Query identity:100%] Trophinin, isoform CRA_a Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007566 [embryo implantation] Show all	706 aa 77 kDa	No	0
TRO-011 ENSP00000382641 ENST00000399736	Q12816 [Direct mapping] Trophinin Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007566 [embryo implantation] Show all	309 aa 35.6 kDa	No	0
TRO-012 ENSP00000411717 ENST00000430420	B1AKF5 [Direct mapping] Trophinin Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		192 aa 19.9 kDa	No	0
TRO-013 ENSP00000392841 ENST00000449980	B1AKF4 [Direct mapping] Trophinin Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		123 aa 12.9 kDa	No	0
TRO-014 ENSP00000404767 ENST00000416704	B1AKE6 [Direct mapping] Trophinin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		169 aa 18 kDa	No	0
TRO-015 ENSP00000406574 ENST00000440759	B1AKE7 [Direct mapping] Trophinin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		176 aa 18.8 kDa	No	0
TRO-016 ENSP00000405043 ENST00000440072		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		3 aa 0.4 kDa	No	0
TRO-017 ENSP00000318278 ENST00000319167	Q12816 [Direct mapping] Trophinin A0A024R9X0 [Target identity:100%; Query identity:100%] Trophinin, isoform CRA_a Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007566 [embryo implantation] Show all	706 aa 77 kDa	No	0
TRO-018 ENSP00000412588 ENST00000453081	B1AKF2 [Direct mapping] Trophinin Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		64 aa 6.8 kDa	No	0
TRO-019 ENSP00000407996 ENST00000431115	B1AKE8 [Direct mapping] Trophinin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		102 aa 12.3 kDa	No	0
TRO-021 ENSP00000404645 ENST00000442098	A0A0E3D6M6 [Direct mapping] Trophinin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		168 aa 17.9 kDa	No	0
TRO-024 ENSP00000388947 ENST00000411534	B1AKF6 [Direct mapping] Trophinin Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		230 aa 24 kDa	No	0
TRO-201 ENSP00000405126 ENST00000420798	Q12816 [Direct mapping] Trophinin Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007566 [embryo implantation] Show all	962 aa 93.7 kDa	No	0
TRO-202 ENSP00000483142 ENST00000622017	A0A087X070 [Direct mapping] Trophinin Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		357 aa 39.4 kDa	No	0