Fields »
ABOUT
HELP
BLOG
DHX8

GENERAL INFORMATION

Gene name

 DHX8

Gene description

 DEAH (Asp-Glu-Ala-His) box polypeptide 8

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and nuclear expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA049285
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Prostate

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 DHX8 (HGNC Symbol)

Synonyms

 DDX8, HRH1, PRP22, PRPF22

Description

 DEAH (Asp-Glu-Ala-His) box polypeptide 8 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the DEAH box polypeptide family. The encoded protein contains the DEAH (Asp-Glu-Ala-His) motif which is characteristic of all DEAH box proteins, and is thought to function as an ATP-dependent RNA helicase that regulates the release of spliced mRNAs from spliceosomes prior to their export from the nucleus. This protein may be required for the replication of human immunodeficiency virus type 1 (HIV-1). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

Chromosome

 17

Cytoband

 q21.31

Chromosome location (bp)

 43483865 - 43544463

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000067596 (version 83.38)

Entrez gene

 1659

UniProt

 Q14562 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14562

Antibodypedia

 DHX8 antibodies

PROTEIN BROWSER
DHX8-001
DHX8-002
DHX8-004
DHX8-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DHX8-001
ENSP00000262415
ENST00000262415
Q14562 [Direct mapping]
ATP-dependent RNA helicase DHX8
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0004386 [helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0005737 [cytoplasm]
GO:0006396 [RNA processing]
GO:0008026 [ATP-dependent helicase activity]
GO:0008380 [RNA splicing]
GO:0042802 [identical protein binding]
GO:0044822 [poly(A) RNA binding]
GO:0071013 [catalytic step 2 spliceosome]
Show all
 1220 aa
139.3 kDa 		Yes 0
DHX8-002
ENSP00000437886
ENST00000540306
F5H658 [Direct mapping]
ATP-dependent RNA helicase DHX8
Show all
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0004386 [helicase activity]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0008026 [ATP-dependent helicase activity]
GO:0008152 [metabolic process]
Show all
 1181 aa
134 kDa 		Yes 0
DHX8-004
ENSP00000465178
ENST00000587574
K7EJH9 [Direct mapping]
ATP-dependent RNA helicase DHX8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
Show all
 33 aa
3.8 kDa 		No 0
DHX8-006
ENSP00000466900
ENST00000589898
K7END7 [Direct mapping]
ATP-dependent RNA helicase DHX8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
Show all
 138 aa
16 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.