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PRKCZ

GENERAL INFORMATION

Gene name

 PRKCZ

Gene description

 Protein kinase C, zeta

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 17
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cerebral cortex)
GTEx:Tissue enhanced (cerebellum)
FANTOM5:Tissue enhanced (cerebellum, placenta)

Protein evidence

 Evidence at protein level

Protein expression

 Membranous and cytoplasmic expression in most tissues, including brain, kidney and retina.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA021851
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Eye
N/A
Retina
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Retina

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebellum)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebellum, placenta)

GENE INFORMATION

Gene name

 PRKCZ (HGNC Symbol)

Synonyms

 PKC2

Description

 Protein kinase C, zeta (HGNC Symbol)

Entrez gene summary

 Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p36.33

Chromosome location (bp)

 2050470 - 2185395

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000067606 (version 83.38)

Entrez gene

 5590

UniProt

 Q05513 (UniProt - Evidence at protein level)

neXtProt

 NX_Q05513

Antibodypedia

 PRKCZ antibodies

PROTEIN BROWSER
«
PRKCZ-001
PRKCZ-003
PRKCZ-004
PRKCZ-006
PRKCZ-007
PRKCZ-009
PRKCZ-010
PRKCZ-011
PRKCZ-015
PRKCZ-016
PRKCZ-017
PRKCZ-018
PRKCZ-020
PRKCZ-021
PRKCZ-022
PRKCZ-026
PRKCZ-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PRKCZ-001
ENSP00000367830
ENST00000378567
Q05513 [Direct mapping]
Protein kinase C zeta type
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0001954 [positive regulation of cell-matrix adhesion]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004697 [protein kinase C activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005923 [bicellular tight junction]
GO:0005938 [cell cortex]
GO:0006468 [protein phosphorylation]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0007616 [long-term memory]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0015459 [potassium channel regulator activity]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0016363 [nuclear matrix]
GO:0016477 [cell migration]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0019901 [protein kinase binding]
GO:0019904 [protein domain specific binding]
GO:0030010 [establishment of cell polarity]
GO:0030054 [cell junction]
GO:0030168 [platelet activation]
GO:0031252 [cell leading edge]
GO:0031333 [negative regulation of protein complex assembly]
GO:0031532 [actin cytoskeleton reorganization]
GO:0031584 [activation of phospholipase D activity]
GO:0031941 [filamentous actin]
GO:0031982 [vesicle]
GO:0032148 [activation of protein kinase B activity]
GO:0032753 [positive regulation of interleukin-4 production]
GO:0032869 [cellular response to insulin stimulus]
GO:0034613 [cellular protein localization]
GO:0035556 [intracellular signal transduction]
GO:0035748 [myelin sheath abaxonal region]
GO:0043066 [negative regulation of apoptotic process]
GO:0043203 [axon hillock]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043234 [protein complex]
GO:0043274 [phospholipase binding]
GO:0043560 [insulin receptor substrate binding]
GO:0045121 [membrane raft]
GO:0045179 [apical cortex]
GO:0045630 [positive regulation of T-helper 2 cell differentiation]
GO:0046326 [positive regulation of glucose import]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
GO:0046628 [positive regulation of insulin receptor signaling pathway]
GO:0046872 [metal ion binding]
GO:0047496 [vesicle transport along microtubule]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050732 [negative regulation of peptidyl-tyrosine phosphorylation]
GO:0050806 [positive regulation of synaptic transmission]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051222 [positive regulation of protein transport]
GO:0051291 [protein heterooligomerization]
GO:0051346 [negative regulation of hydrolase activity]
GO:0051899 [membrane depolarization]
GO:0060081 [membrane hyperpolarization]
GO:0060291 [long-term synaptic potentiation]
GO:0070062 [extracellular exosome]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070528 [protein kinase C signaling]
GO:0071889 [14-3-3 protein binding]
GO:0072659 [protein localization to plasma membrane]
GO:1990138 [neuron projection extension]
GO:2000463 [positive regulation of excitatory postsynaptic potential]
GO:2000553 [positive regulation of T-helper 2 cell cytokine production]
GO:2000664 [positive regulation of interleukin-5 secretion]
GO:2000667 [positive regulation of interleukin-13 secretion]
GO:2001181 [positive regulation of interleukin-10 secretion]
Show all
 592 aa
67.7 kDa 		No 0
PRKCZ-003
ENSP00000425317
ENST00000482686
D6RDM0 [Direct mapping]
Protein kinase C zeta type
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 73 aa
8 kDa 		No 0
PRKCZ-004
ENSP00000422349
ENST00000471018
D6RC84 [Direct mapping]
Protein kinase C zeta type
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 46 aa
5.1 kDa 		No 0
PRKCZ-006
ENSP00000427134
ENST00000466352
D6RCN4 [Direct mapping]
Protein kinase C zeta type
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 25 aa
2.8 kDa 		No 0
PRKCZ-007
ENSP00000424945
ENST00000468310
F2Z3C5 [Direct mapping]
Protein kinase C zeta type
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0035556 [intracellular signal transduction]
GO:0046872 [metal ion binding]
Show all
 181 aa
20.7 kDa 		No 0
PRKCZ-009
ENSP00000383712
ENST00000400921
Q05513 [Direct mapping]
Protein kinase C zeta type
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004697 [protein kinase C activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0006468 [protein phosphorylation]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0016020 [membrane]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0030010 [establishment of cell polarity]
GO:0030054 [cell junction]
GO:0030168 [platelet activation]
GO:0031333 [negative regulation of protein complex assembly]
GO:0031982 [vesicle]
GO:0032753 [positive regulation of interleukin-4 production]
GO:0043560 [insulin receptor substrate binding]
GO:0045630 [positive regulation of T-helper 2 cell differentiation]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
GO:0046628 [positive regulation of insulin receptor signaling pathway]
GO:0046872 [metal ion binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0050732 [negative regulation of peptidyl-tyrosine phosphorylation]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0060291 [long-term synaptic potentiation]
GO:0070062 [extracellular exosome]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:2000463 [positive regulation of excitatory postsynaptic potential]
GO:2000553 [positive regulation of T-helper 2 cell cytokine production]
GO:2000664 [positive regulation of interleukin-5 secretion]
GO:2000667 [positive regulation of interleukin-13 secretion]
GO:2001181 [positive regulation of interleukin-10 secretion]
Show all
 409 aa
46.6 kDa 		No 0
PRKCZ-010
ENSP00000421219
ENST00000470986
D6RGG1 [Direct mapping]
Protein kinase C zeta type
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 109 aa
12.2 kDa 		No 0
PRKCZ-011
ENSP00000422764
ENST00000497183
F2Z2H9 [Direct mapping]
Protein kinase C zeta type
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 105 aa
11.7 kDa 		No 0
PRKCZ-015
ENSP00000426412
ENST00000461106
Q05513 [Direct mapping]
Protein kinase C zeta type
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004697 [protein kinase C activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0006468 [protein phosphorylation]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0016020 [membrane]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0030010 [establishment of cell polarity]
GO:0030054 [cell junction]
GO:0030168 [platelet activation]
GO:0031333 [negative regulation of protein complex assembly]
GO:0031982 [vesicle]
GO:0032753 [positive regulation of interleukin-4 production]
GO:0035556 [intracellular signal transduction]
GO:0043560 [insulin receptor substrate binding]
GO:0045630 [positive regulation of T-helper 2 cell differentiation]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
GO:0046628 [positive regulation of insulin receptor signaling pathway]
GO:0046872 [metal ion binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0050732 [negative regulation of peptidyl-tyrosine phosphorylation]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0060291 [long-term synaptic potentiation]
GO:0070062 [extracellular exosome]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:2000463 [positive regulation of excitatory postsynaptic potential]
GO:2000553 [positive regulation of T-helper 2 cell cytokine production]
GO:2000664 [positive regulation of interleukin-5 secretion]
GO:2000667 [positive regulation of interleukin-13 secretion]
GO:2001181 [positive regulation of interleukin-10 secretion]
Show all
 488 aa
56.1 kDa 		No 0
PRKCZ-016
ENSP00000462105
ENST00000461465
J3KRP7 [Direct mapping]
Protein kinase C zeta type
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 61 aa
6.7 kDa 		No 0
PRKCZ-017
ENSP00000424228
ENST00000470596
D6RBD4 [Direct mapping]
Protein kinase C zeta type
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 98 aa
10.9 kDa 		No 0
PRKCZ-018
ENSP00000421869
ENST00000496325
D6RAN5 [Direct mapping]
Protein kinase C zeta type
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 71 aa
7.8 kDa 		No 0
PRKCZ-020
ENSP00000427085
ENST00000495347
D6RD31 [Direct mapping]
Protein kinase C zeta type
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 21 aa
2.3 kDa 		No 0
PRKCZ-021
ENSP00000421350
ENST00000470511
D6RG01 [Direct mapping]
Protein kinase C zeta type
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 82 aa
9 kDa 		No 0
PRKCZ-022
ENSP00000424763
ENST00000486681
D6RAU1 [Direct mapping]
Protein kinase C zeta type
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 136 aa
15.3 kDa 		No 0
PRKCZ-026
ENSP00000421587
ENST00000503297
D6REZ8 [Direct mapping]
Protein kinase C zeta type
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 65 aa
7.4 kDa 		No 0
PRKCZ-201
ENSP00000383711
ENST00000400920
Q05513 [Direct mapping]
Protein kinase C zeta type
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004697 [protein kinase C activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0006468 [protein phosphorylation]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0016020 [membrane]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0030010 [establishment of cell polarity]
GO:0030054 [cell junction]
GO:0030168 [platelet activation]
GO:0031333 [negative regulation of protein complex assembly]
GO:0031982 [vesicle]
GO:0032753 [positive regulation of interleukin-4 production]
GO:0043560 [insulin receptor substrate binding]
GO:0045630 [positive regulation of T-helper 2 cell differentiation]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
GO:0046628 [positive regulation of insulin receptor signaling pathway]
GO:0046872 [metal ion binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0050732 [negative regulation of peptidyl-tyrosine phosphorylation]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0060291 [long-term synaptic potentiation]
GO:0070062 [extracellular exosome]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:2000463 [positive regulation of excitatory postsynaptic potential]
GO:2000553 [positive regulation of T-helper 2 cell cytokine production]
GO:2000664 [positive regulation of interleukin-5 secretion]
GO:2000667 [positive regulation of interleukin-13 secretion]
GO:2001181 [positive regulation of interleukin-10 secretion]
Show all
 409 aa
46.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.