Expression of PDZD4 in cancer - Summary - The Human Protein Atlas

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PDZD4

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PDZD4
Gene description	PDZ domain containing 4
Protein class	Cancer-related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (glioma)
HPA (cell line):	Cell line enhanced (AF22, RH-30, SCLC-21H, SH-SY5Y)
HPA (normal tissue):	Tissue enriched (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear and cytoplasmic expression in CNS.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. HPA003878
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable).
Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (glioma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA003878

GENE INFORMATION
Gene name	PDZD4 (HGNC Symbol)
Synonyms	FLJ34125, KIAA1444, LU1, PDZK4, PDZRN4L
Description	PDZ domain containing 4 (HGNC Symbol)
Entrez gene summary
Chromosome	X
Cytoband	q28
Chromosome location (bp)	153802166 - 153830565
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000067840 (version 83.38)
Entrez gene	57595
UniProt	Q76G19 (UniProt - Evidence at protein level)
neXtProt	NX_Q76G19
Antibodypedia	PDZD4 antibodies

PROTEIN BROWSER

PDZD4-002	PDZD4-201	PDZD4-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PDZD4-002 ENSP00000164640 ENST00000164640	Q76G19 [Direct mapping] PDZ domain-containing protein 4 Show all	Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005938 [cell cortex] GO:0016567 [protein ubiquitination] GO:0061630 [ubiquitin protein ligase activity] Show all	769 aa 86.2 kDa	No	0
PDZD4-201 ENSP00000377355 ENST00000393758	Q17RL8 [Direct mapping] HCG2004980, isoform CRA_e; PDZ domain-containing protein 4; PDZD4 protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016567 [protein ubiquitination] GO:0061630 [ubiquitin protein ligase activity] Show all	775 aa 86.9 kDa	No	0
PDZD4-202 ENSP00000442033 ENST00000544474	Q76G19 [Direct mapping] PDZ domain-containing protein 4 Show all	Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005938 [cell cortex] GO:0016567 [protein ubiquitination] GO:0061630 [ubiquitin protein ligase activity] Show all	660 aa 73.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.