Expression of ATP2B3 in cancer - Summary

GENERAL INFORMATION
Gene name	ATP2B3
Gene description	ATPase, Ca++ transporting, plasma membrane 3
Protein class	Cancer-related genes Disease related genes Enzymes Plasma proteins Potential drug targets Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Cell line enhanced (SCLC-21H, SH-SY5Y, U-937)
HPA (normal tissue):	Group enriched (adrenal gland, cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in CNS, including granular layer and Purkinje cells in cerebellum.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded. External characterization data supports antibody staining.
Reliability score	Supported based on 1 antibody. HPA001583
	SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

STAINING SUMMARY

HPA001583

GENE INFORMATION
Gene name	ATP2B3 (HGNC Symbol)
Synonyms	CFAP39, CLA2, PMCA3, SCAX1
Description	ATPase, Ca++ transporting, plasma membrane 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 3. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Chromosome	X
Cytoband	q28
Chromosome location (bp)	153517676 - 153582939
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000067842 (version 83.38)
Entrez gene	492
UniProt	Q16720 (UniProt - Evidence at protein level)
neXtProt	NX_Q16720
Antibodypedia	ATP2B3 antibodies

PROTEIN BROWSER

ATP2B3-001	ATP2B3-002	ATP2B3-004	ATP2B3-006	ATP2B3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATP2B3-001 ENSP00000359205 ENST00000370186	Q16720 [Direct mapping] Plasma membrane calcium-transporting ATPase 3 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005388 [calcium-transporting ATPase activity] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006874 [cellular calcium ion homeostasis] GO:0007596 [blood coagulation] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030165 [PDZ domain binding] GO:0034220 [ion transmembrane transport] GO:0046872 [metal ion binding] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] GO:0098655 [cation transmembrane transport] GO:1903561 [extracellular vesicle] Show all	1159 aa 127.1 kDa	No	>9
ATP2B3-002 ENSP00000343886 ENST00000349466	Q16720 [Direct mapping] Plasma membrane calcium-transporting ATPase 3 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005388 [calcium-transporting ATPase activity] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006874 [cellular calcium ion homeostasis] GO:0007596 [blood coagulation] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030165 [PDZ domain binding] GO:0034220 [ion transmembrane transport] GO:0046872 [metal ion binding] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] GO:0098655 [cation transmembrane transport] GO:1903561 [extracellular vesicle] Show all	1220 aa 134.2 kDa	No	>9
ATP2B3-004 ENSP00000377425 ENST00000393842	Q16720 [Direct mapping] Plasma membrane calcium-transporting ATPase 3 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005388 [calcium-transporting ATPase activity] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006874 [cellular calcium ion homeostasis] GO:0007596 [blood coagulation] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030165 [PDZ domain binding] GO:0034220 [ion transmembrane transport] GO:0046872 [metal ion binding] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] GO:0098655 [cation transmembrane transport] GO:1903561 [extracellular vesicle] Show all	1154 aa 126.6 kDa	No	>9
ATP2B3-006 ENSP00000352062 ENST00000359149	Q16720 [Direct mapping] Plasma membrane calcium-transporting ATPase 3 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005388 [calcium-transporting ATPase activity] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006874 [cellular calcium ion homeostasis] GO:0007596 [blood coagulation] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030165 [PDZ domain binding] GO:0034220 [ion transmembrane transport] GO:0046872 [metal ion binding] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] GO:0098655 [cation transmembrane transport] GO:1903561 [extracellular vesicle] Show all	1173 aa 128.5 kDa	No	>9
ATP2B3-201 ENSP00000263519 ENST00000263519	Q16720 [Direct mapping] Plasma membrane calcium-transporting ATPase 3 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005388 [calcium-transporting ATPase activity] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006874 [cellular calcium ion homeostasis] GO:0007596 [blood coagulation] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030165 [PDZ domain binding] GO:0034220 [ion transmembrane transport] GO:0046872 [metal ion binding] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] GO:0098655 [cation transmembrane transport] GO:1903561 [extracellular vesicle] Show all	1220 aa 134.2 kDa	No	>9