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PDK3

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GENERAL INFORMATION

Gene name

 PDK3

Gene description

 Pyruvate dehydrogenase kinase, isozyme 3

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the mitochondria. In addition localized to the nucleoli.

RNA cell category

 Mixed

Protein evidence

 Evidence at protein level

Main location

 Localized to the Mitochondria (supported)

Additional location

 In addition localized to the Nucleoli (approved)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA072492
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the mitochondria. In addition localized to the nucleoli.

Main location

 Mitochondria (supported)

Additional location

 Nucleoli (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA072492 MCF7 Nucleoli
Mitochondria
HPA072492 RT4 Mitochondria
HPA072492 U-2 OS Nucleoli

GENE INFORMATION

Gene name

 PDK3

Synonyms

Description

 Pyruvate dehydrogenase kinase, isozyme 3 (HGNC Symbol)

Entrez gene summary

 The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle, and thus is one of the major enzymes responsible for the regulation of glucose metabolism. The enzymatic activity of PDH is regulated by a phosphorylation/dephosphorylation cycle, and phosphorylation results in inactivation of PDH. The protein encoded by this gene is one of the three pyruvate dehydrogenase kinases that inhibits the PDH complex by phosphorylation of the E1 alpha subunit. This gene is predominantly expressed in the heart and skeletal muscles. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

Chromosome

 X

Cytoband

 p22.11

Chromosome location (bp)

 24465221 - 24539837

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000067992 (version 83.38)

Entrez gene

 5165

UniProt

 Q15120 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15120

Antibodypedia

 PDK3 antibodies

PROTEIN BROWSER
PDK3-001
PDK3-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PDK3-001
ENSP00000368460
ENST00000379162
Q15120 [Direct mapping]
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Atypical kinases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004740 [pyruvate dehydrogenase (acetyl-transferring) kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006006 [glucose metabolic process]
GO:0006090 [pyruvate metabolic process]
GO:0010510 [regulation of acetyl-CoA biosynthetic process from pyruvate]
GO:0010906 [regulation of glucose metabolic process]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0035357 [peroxisome proliferator activated receptor signaling pathway]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0071333 [cellular response to glucose stimulus]
GO:0071398 [cellular response to fatty acid]
GO:0097411 [hypoxia-inducible factor-1alpha signaling pathway]
GO:2000377 [regulation of reactive oxygen species metabolic process]
Show all
 406 aa
46.9 kDa 		No 0
PDK3-003
ENSP00000387536
ENST00000441463
Q15120 [Direct mapping]
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Atypical kinases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004740 [pyruvate dehydrogenase (acetyl-transferring) kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006006 [glucose metabolic process]
GO:0006090 [pyruvate metabolic process]
GO:0010510 [regulation of acetyl-CoA biosynthetic process from pyruvate]
GO:0010906 [regulation of glucose metabolic process]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0035357 [peroxisome proliferator activated receptor signaling pathway]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0071333 [cellular response to glucose stimulus]
GO:0071398 [cellular response to fatty acid]
GO:0097411 [hypoxia-inducible factor-1alpha signaling pathway]
GO:2000377 [regulation of reactive oxygen species metabolic process]
Show all
 415 aa
48 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.