Fields »
ABOUT
HELP
BLOG
RASSF1

GENERAL INFORMATION

Gene name

 RASSF1

Gene description

 Ras association (RalGDS/AF-6) domain family member 1

Protein class

 Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA040735
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), head and neck cancer (favourable), cervical cancer (favourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Head and neck cancer p<0.001
Cervical cancer p<0.001
Liver cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA040735

GENE INFORMATION

Gene name

 RASSF1 (HGNC Symbol)

Synonyms

 123F2, NORE2A, RDA32, REH3P21

Description

 Ras association (RalGDS/AF-6) domain family member 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, May 2011]

Chromosome

 3

Cytoband

 p21.31

Chromosome location (bp)

 50329782 - 50340980

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000068028 (version 83.38)

Entrez gene

 11186

UniProt

 Q9NS23 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NS23

Antibodypedia

 RASSF1 antibodies

PROTEIN BROWSER
RASSF1-001
RASSF1-002
RASSF1-005
RASSF1-007
RASSF1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RASSF1-001
ENSP00000352323
ENST00000359365
Q9NS23 [Direct mapping]
Ras association domain-containing protein 1
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000922 [spindle pole]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007050 [cell cycle arrest]
GO:0007165 [signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0008270 [zinc ion binding]
GO:0015630 [microtubule cytoskeleton]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0035556 [intracellular signal transduction]
GO:0042802 [identical protein binding]
GO:0047485 [protein N-terminus binding]
GO:0050821 [protein stabilization]
GO:0071157 [negative regulation of cell cycle arrest]
Show all
 340 aa
38.8 kDa 		No 0
RASSF1-002
ENSP00000349547
ENST00000357043
Q9NS23 [Direct mapping]
Ras association domain-containing protein 1
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000922 [spindle pole]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007050 [cell cycle arrest]
GO:0007165 [signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0008270 [zinc ion binding]
GO:0015630 [microtubule cytoskeleton]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0035556 [intracellular signal transduction]
GO:0042802 [identical protein binding]
GO:0047485 [protein N-terminus binding]
GO:0050821 [protein stabilization]
GO:0071157 [negative regulation of cell cycle arrest]
Show all
 344 aa
39.2 kDa 		No 0
RASSF1-005
ENSP00000378558
ENST00000395126
Q9NS23 [Direct mapping]
Ras association domain-containing protein 1
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000922 [spindle pole]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007050 [cell cycle arrest]
GO:0007165 [signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0008270 [zinc ion binding]
GO:0015630 [microtubule cytoskeleton]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0042802 [identical protein binding]
GO:0047485 [protein N-terminus binding]
GO:0050821 [protein stabilization]
GO:0071157 [negative regulation of cell cycle arrest]
Show all
 189 aa
21.9 kDa 		No 0
RASSF1-007
ENSP00000333327
ENST00000327761
Q9NS23 [Direct mapping]
Ras association domain-containing protein 1
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000922 [spindle pole]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007050 [cell cycle arrest]
GO:0007165 [signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0008270 [zinc ion binding]
GO:0015630 [microtubule cytoskeleton]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0042802 [identical protein binding]
GO:0047485 [protein N-terminus binding]
GO:0050821 [protein stabilization]
GO:0071157 [negative regulation of cell cycle arrest]
Show all
 270 aa
31.2 kDa 		No 0
RASSF1-201
ENSP00000482696
ENST00000616212
Q9NS23 [Direct mapping]
Ras association domain-containing protein 1
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000922 [spindle pole]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007050 [cell cycle arrest]
GO:0007165 [signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0008270 [zinc ion binding]
GO:0015630 [microtubule cytoskeleton]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0042802 [identical protein binding]
GO:0047485 [protein N-terminus binding]
GO:0050821 [protein stabilization]
GO:0071157 [negative regulation of cell cycle arrest]
Show all
 189 aa
21.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.