Expression of INPP5A in cancer - Summary - The Human Protein Atlas

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INPP5A

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	INPP5A
Gene description	Inositol polyphosphate-5-phosphatase A
Protein class	Enzymes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA012285
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and breast cancer (unfavourable).
Renal cancer p<0.001 Breast cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA012285

GENE INFORMATION
Gene name	INPP5A (HGNC Symbol)
Synonyms	5PTASE
Description	Inositol polyphosphate-5-phosphatase A (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a membrane-associated type I inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. [provided by RefSeq, Jul 2008]
Chromosome	10
Cytoband	q26.3
Chromosome location (bp)	132537820 - 132783480
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000068383 (version 83.38)
Entrez gene	3632
UniProt	Q14642 (UniProt - Evidence at protein level)
neXtProt	NX_Q14642
Antibodypedia	INPP5A antibodies

PROTEIN BROWSER

INPP5A-001	INPP5A-002	INPP5A-003	INPP5A-004	INPP5A-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
INPP5A-001 ENSP00000357583 ENST00000368594	Q14642 [Direct mapping] Type I inositol 1,4,5-trisphosphate 5-phosphatase Show all	Enzymes ENZYME proteins Hydrolases Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004445 [inositol-polyphosphate 5-phosphatase activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0016020 [membrane] GO:0042731 [PH domain binding] GO:0043647 [inositol phosphate metabolic process] GO:0044281 [small molecule metabolic process] GO:0046856 [phosphatidylinositol dephosphorylation] GO:0052658 [inositol-1,4,5-trisphosphate 5-phosphatase activity] GO:0052659 [inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity] GO:0070062 [extracellular exosome] Show all	412 aa 47.8 kDa	Yes	0
INPP5A-002 ENSP00000357582 ENST00000368593	Q5T1B5 [Direct mapping] Type I inositol 1,4,5-trisphosphate 5-phosphatase Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016787 [hydrolase activity] GO:0046856 [phosphatidylinositol dephosphorylation] Show all	387 aa 44.9 kDa	Yes	0
INPP5A-003 ENSP00000340707 ENST00000342652	H0Y2W5 [Direct mapping] Type I inositol 1,4,5-trisphosphate 5-phosphatase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016787 [hydrolase activity] GO:0046856 [phosphatidylinositol dephosphorylation] Show all	278 aa 33 kDa	No	0
INPP5A-004 ENSP00000390936 ENST00000423490	Q5T1B3 [Direct mapping] Type I inositol 1,4,5-trisphosphate 5-phosphatase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016787 [hydrolase activity] GO:0046856 [phosphatidylinositol dephosphorylation] Show all	138 aa 16.2 kDa	No	0
INPP5A-007 ENSP00000390749 ENST00000445580	B1AP38 [Direct mapping] Type I inositol 1,4,5-trisphosphate 5-phosphatase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		104 aa 11.9 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.