Expression of PAGE1 in cancer - Summary - The Human Protein Atlas

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PAGE1
Gene description	P antigen family, member 1 (prostate associated)
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (liver cancer)
HPA (cell line):	Group enriched (A-431, Karpas-707, U-266/84)
HPA (normal tissue):	Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective nuclear expression in testis.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA003473
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (liver cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA003473

GENE INFORMATION
Gene name	PAGE1 (HGNC Symbol)
Synonyms	CT16.3, GAGE-9, GAGEB1, PAGE-1
Description	P antigen family, member 1 (prostate associated) (HGNC Symbol)
Entrez gene summary	This gene belongs to a family of genes that are expressed in a variety of tumors but not in normal tissues, except for the testis. Unlike the other gene family members, this gene does not encode an antigenic peptide. Nothing is presently known about the function of this protein. [provided by RefSeq, Jul 2008]
Chromosome	X
Cytoband	p11.23
Chromosome location (bp)	49687450 - 49695993
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000068985 (version 83.38)
Entrez gene	8712
UniProt	O75459 (UniProt - Evidence at protein level)
neXtProt	NX_O75459
Antibodypedia	PAGE1 antibodies

PROTEIN BROWSER

PAGE1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PAGE1-001 ENSP00000365320 ENST00000376150	O75459 [Direct mapping] P antigen family member 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0006968 [cellular defense response] Show all	146 aa 16.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.