Expression of MAST4 in cancer - Summary

GENERAL INFORMATION
Gene name	MAST4
Gene description	Microtubule associated serine/threonine kinase family member 4
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	16
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (HDLM-2, RT4)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Mainly cytoplasmic expression in several tissues, high in esophagus and urinary bladder.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA000544
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (favourable).
Head and neck cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA000544

GENE INFORMATION
Gene name	MAST4 (HGNC Symbol)
Synonyms	KIAA0303
Description	Microtubule associated serine/threonine kinase family member 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the microtubule-associated serine/threonine protein kinases. The proteins in this family contain a domain that gives the kinase the ability to determine its own scaffold to control the effects of their kinase activities. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]
Chromosome	5
Cytoband	q12.3
Chromosome location (bp)	66596361 - 67169595
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000069020 (version 83.38)
Entrez gene	375449
UniProt	O15021 (UniProt - Evidence at protein level)
neXtProt	NX_O15021
Antibodypedia	MAST4 antibodies

PROTEIN BROWSER

MAST4-001	MAST4-002	MAST4-003	MAST4-004	MAST4-005	MAST4-007	MAST4-010	MAST4-011	MAST4-015	MAST4-016	MAST4-018	MAST4-019	MAST4-020	MAST4-022	MAST4-023	MAST4-024

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MAST4-001 ENSP00000385727 ENST00000403625	J3QT34 [Direct mapping] Non-specific serine/threonine protein kinase Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	2623 aa 284.1 kDa	No	0
MAST4-002 ENSP00000384313 ENST00000403666	O15021 [Direct mapping] Microtubule-associated serine/threonine-protein kinase 4 Show all	Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0018105 [peptidyl-serine phosphorylation] GO:0035556 [intracellular signal transduction] Show all	2434 aa 265.4 kDa	No	0
MAST4-003 ENSP00000384099 ENST00000405643	E7EWQ5 [Direct mapping] Non-specific serine/threonine protein kinase Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	2444 aa 266.2 kDa	No	0
MAST4-004 ENSP00000400551 ENST00000443808	H7C1I9 [Direct mapping] Microtubule-associated serine/threonine-protein kinase 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	1680 aa 179.9 kDa	No	0
MAST4-005 ENSP00000421739 ENST00000490016	D6RAK1 [Direct mapping] Microtubule-associated serine/threonine-protein kinase 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0045075 [regulation of interleukin-12 biosynthetic process] Show all	350 aa 39.4 kDa	No	0
MAST4-007 ENSP00000261569 ENST00000261569	O15021 [Direct mapping] Microtubule-associated serine/threonine-protein kinase 4 Show all	Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0018105 [peptidyl-serine phosphorylation] GO:0035556 [intracellular signal transduction] Show all	2429 aa 264.8 kDa	No	0
MAST4-010 ENSP00000385088 ENST00000406374	O15021 [Direct mapping] Microtubule-associated serine/threonine-protein kinase 4 Show all	Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0005737 [cytoplasm] GO:0018105 [peptidyl-serine phosphorylation] GO:0035556 [intracellular signal transduction] Show all	250 aa 25.7 kDa	No	0
MAST4-011 ENSP00000384547 ENST00000406039	E7EX28 [Direct mapping] Microtubule-associated serine/threonine-protein kinase 4 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		238 aa 24.3 kDa	No	0
MAST4-015 ENSP00000413573 ENST00000432817	H7C3S4 [Direct mapping] Microtubule-associated serine/threonine-protein kinase 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		122 aa 13.3 kDa	No	0
MAST4-016 ENSP00000407977 ENST00000452953	H7C2V7 [Direct mapping] Microtubule-associated serine/threonine-protein kinase 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		99 aa 10.5 kDa	No	0
MAST4-018 ENSP00000396765 ENST00000434115	H7C0U3 [Direct mapping] Microtubule-associated serine/threonine-protein kinase 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		80 aa 8.5 kDa	No	0
MAST4-019 ENSP00000398417 ENST00000411628	H7C146 [Direct mapping] Microtubule-associated serine/threonine-protein kinase 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		66 aa 7.4 kDa	No	0
MAST4-020 ENSP00000404801 ENST00000450827	H7C2A9 [Direct mapping] Microtubule-associated serine/threonine-protein kinase 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		58 aa 6.7 kDa	No	0
MAST4-022 ENSP00000413854 ENST00000432426	C9JKM7 [Direct mapping] Microtubule-associated serine/threonine-protein kinase 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004674 [protein serine/threonine kinase activity] GO:0006468 [protein phosphorylation] GO:0045075 [regulation of interleukin-12 biosynthetic process] Show all	59 aa 6.4 kDa	No	0
MAST4-023 ENSP00000385260 ENST00000407621	B5MC73 [Direct mapping] Microtubule-associated serine/threonine-protein kinase 4 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		56 aa 6 kDa	No	0
MAST4-024 ENSP00000392478 ENST00000436277	C9J249 [Direct mapping] Microtubule-associated serine/threonine-protein kinase 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0045075 [regulation of interleukin-12 biosynthetic process] Show all	168 aa 18.6 kDa	No	0