Expression of ADAM7 in cancer - Summary - The Human Protein Atlas

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ADAM7

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ADAM7
Gene description	ADAM metallopeptidase domain 7
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (prostate cancer, renal cancer)
HPA (cell line):	Group enriched (BEWO, NB-4, RPMI-8226, SH-SY5Y)
HPA (normal tissue):	Tissue enriched (epididymis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in epididymis.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Pending external verification.
Reliability score	Supported based on 1 antibody. HPA008879
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (prostate cancer, renal cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA008879

GENE INFORMATION
Gene name	ADAM7 (HGNC Symbol)
Synonyms	EAPI, GP-83
Description	ADAM metallopeptidase domain 7 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the ADAMs family of zinc proteases. These transmembrane proteins play roles in multiple processes including cell signaling, adhesion and migration. The encoded protein lacks protease activity and may play roles in protein-protein interactions and cell adhesion processes including sperm-egg fusion. Mutations in this gene may be involved in the progression of melanoma. [provided by RefSeq, Oct 2011]
Chromosome	8
Cytoband	p21.2
Chromosome location (bp)	24440930 - 24526970
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000069206 (version 83.38)
Entrez gene	8756
UniProt	Q9H2U9 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H2U9
Antibodypedia	ADAM7 antibodies

PROTEIN BROWSER

ADAM7-001	ADAM7-002	ADAM7-003	ADAM7-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADAM7-001 ENSP00000175238 ENST00000175238	Q9H2U9 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 7 Show all	Enzymes Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004175 [endopeptidase activity] GO:0004222 [metalloendopeptidase activity] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] Show all	754 aa 85.7 kDa	Yes	1
ADAM7-002 ENSP00000370166 ENST00000380789	C9JK28 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 7 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] Show all	776 aa 88.1 kDa	Yes	1
ADAM7-003 ENSP00000393073 ENST00000441335	Q9H2U9 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 7 Show all	Enzymes Peptidases Metallopeptidases MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] Show all	210 aa 24.4 kDa	Yes	0
ADAM7-004 ENSP00000430400 ENST00000520720	E5RK87 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 7 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0016021 [integral component of membrane] Show all	516 aa 58.1 kDa	No	1

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.