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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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ADAM7
  • premium

    TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

ADAM7

Gene description

ADAM metallopeptidase domain 7

Protein class

Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Membrane,Secreted

Number of transcripts

4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Group enriched (prostate cancer, renal cancer)
HPA (cell line):Group enriched (BEWO, NB-4, RPMI-8226, SH-SY5Y)
HPA (normal tissue):Tissue enriched (epididymis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in epididymis.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data. Pending external verification.

Reliability score

Supported based on 1 antibody.
HPA008879
SHOW MORE

PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Group enriched (prostate cancer, renal cancer)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY

HPA008879

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

All cancer tissues were negative.

GENE INFORMATION

Gene name

ADAM7 (HGNC Symbol)

Synonyms

EAPI, GP-83

Description

ADAM metallopeptidase domain 7 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the ADAMs family of zinc proteases. These transmembrane proteins play roles in multiple processes including cell signaling, adhesion and migration. The encoded protein lacks protease activity and may play roles in protein-protein interactions and cell adhesion processes including sperm-egg fusion. Mutations in this gene may be involved in the progression of melanoma. [provided by RefSeq, Oct 2011]

Chromosome

8

Cytoband

p21.2

Chromosome location (bp)

24440930 - 24526970

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000069206 (version 83.38)

Entrez gene

8756

UniProt

Q9H2U9 (UniProt - Evidence at protein level)

neXtProt

NX_Q9H2U9

Antibodypedia

ADAM7 antibodies

PROTEIN BROWSER

ADAM7-001
ADAM7-002
ADAM7-003
ADAM7-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADAM7-001
ENSP00000175238
ENST00000175238
Q9H2U9 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 7
Show all
Enzymes
   Peptidases
   Metallopeptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004175 [endopeptidase activity]
GO:0004222 [metalloendopeptidase activity]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0008270 [zinc ion binding]
GO:0016021 [integral component of membrane]
Show all
754 aa
85.7 kDa
Yes 1
ADAM7-002
ENSP00000370166
ENST00000380789
C9JK28 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 7
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0006508 [proteolysis]
GO:0008270 [zinc ion binding]
GO:0016021 [integral component of membrane]
Show all
776 aa
88.1 kDa
Yes 1
ADAM7-003
ENSP00000393073
ENST00000441335
Q9H2U9 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 7
Show all
Enzymes
   Peptidases
   Metallopeptidases
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0006508 [proteolysis]
GO:0008270 [zinc ion binding]
GO:0016021 [integral component of membrane]
Show all
210 aa
24.4 kDa
Yes 0
ADAM7-004
ENSP00000430400
ENST00000520720
E5RK87 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 7
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0006508 [proteolysis]
GO:0016021 [integral component of membrane]
Show all
516 aa
58.1 kDa
No 1

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