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NUCKS1

GENERAL INFORMATION

Gene name

 NUCKS1

Gene description

 Nuclear casein kinase and cyclin-dependent kinase substrate 1

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA062351
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable).
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA062351

GENE INFORMATION

Gene name

 NUCKS1 (HGNC Symbol)

Synonyms

 NUCKS

Description

 Nuclear casein kinase and cyclin-dependent kinase substrate 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a nuclear protein that is highly conserved in vertebrates. The conserved regions of the protein contain several consensus phosphorylation sites for casein kinase II and cyclin-dependent kinases, two putative nuclear localization signals, and a basic DNA-binding domain. It is phosphorylated in vivo by Cdk1 during mitosis of the cell cycle. [provided by RefSeq, Aug 2010]

Chromosome

 1

Cytoband

 q32.1

Chromosome location (bp)

 205712819 - 205750276

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000069275 (version 83.38)

Entrez gene

 64710

UniProt

 Q9H1E3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H1E3

Antibodypedia

 NUCKS1 antibodies

PROTEIN BROWSER
NUCKS1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NUCKS1-001
ENSP00000356110
ENST00000367142
Q9H1E3 [Direct mapping]
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0042593 [glucose homeostasis]
GO:0044822 [poly(A) RNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046628 [positive regulation of insulin receptor signaling pathway]
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 243 aa
27.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.