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DNAJA2

GENERAL INFORMATION

Gene name

 DNAJA2

Gene description

 DnaJ (Hsp40) homolog, subfamily A, member 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in all tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA060538
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Ovary

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 DNAJA2 (HGNC Symbol)

Synonyms

 CPR3, DNAJ, DNJ3, HIRIP4

Description

 DnaJ (Hsp40) homolog, subfamily A, member 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus; a glycine/phenylalanine (G/F)-rich region; and a cysteine-rich domain containing 4 motifs resembling a zinc finger domain. The product of this gene works as a cochaperone of Hsp70s in protein folding and mitochondrial protein import in vitro. [provided by RefSeq, Jul 2008]

Chromosome

 16

Cytoband

 q11.2

Chromosome location (bp)

 46955362 - 46973788

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000069345 (version 83.38)

Entrez gene

 10294

UniProt

 O60884 (UniProt - Evidence at protein level)

neXtProt

 NX_O60884

Antibodypedia

 DNAJA2 antibodies

PROTEIN BROWSER
DNAJA2-001
DNAJA2-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DNAJA2-001
ENSP00000314030
ENST00000317089
O60884 [Direct mapping]
DnaJ homolog subfamily A member 2
A0A024R6S1 [Target identity:100%; Query identity:100%]
DnaJ (Hsp40) homolog, subfamily A, member 2, isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001948 [glycoprotein binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006457 [protein folding]
GO:0008284 [positive regulation of cell proliferation]
GO:0009408 [response to heat]
GO:0016020 [membrane]
GO:0018885 [carbon tetrachloride metabolic process]
GO:0031072 [heat shock protein binding]
GO:0042026 [protein refolding]
GO:0046872 [metal ion binding]
GO:0051082 [unfolded protein binding]
GO:0051087 [chaperone binding]
GO:0070062 [extracellular exosome]
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 412 aa
45.7 kDa 		No 0
DNAJA2-003
ENSP00000477579
ENST00000617000
A0A087WT48 [Direct mapping]
DnaJ homolog subfamily A member 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006457 [protein folding]
GO:0031072 [heat shock protein binding]
GO:0046872 [metal ion binding]
GO:0051082 [unfolded protein binding]
Show all
 134 aa
14.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.