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ABCC9
  • TISSUE

  • CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

ABCC9

Gene description

ATP-binding cassette, sub-family C (CFTR/MRP), member 9

Protein class

Disease related genes
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

Membrane

Number of transcripts

6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Mixed
GTEx:Mixed
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

RNA data suggests expression in selected tissues.

DATA RELIABILITY

Data reliability
description

Antibody staining not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

Uncertain based on 1 antibody.
HPA007279
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

ABCC9 (HGNC Symbol)

Synonyms

CMD1O, SUR2

Description

ATP-binding cassette, sub-family C (CFTR/MRP), member 9 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is thought to form ATP-sensitive potassium channels in cardiac, skeletal, and vascular and non-vascular smooth muscle. Protein structure suggests a role as the drug-binding channel-modulating subunit of the extra-pancreatic ATP-sensitive potassium channels. Mutations in this gene are associated with cardiomyopathy dilated type 1O. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2011]

Chromosome

12

Cytoband

p12.1

Chromosome location (bp)

21797401 - 21941402

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000069431 (version 83.38)

Entrez gene

10060

UniProt

O60706 (UniProt - Evidence at protein level)

neXtProt

NX_O60706

Antibodypedia

ABCC9 antibodies

PROTEIN BROWSER

ABCC9-001
ABCC9-002
ABCC9-003
ABCC9-004
ABCC9-005
ABCC9-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ABCC9-001
ENSP00000261200
ENST00000261200
O60706 [Direct mapping]
ATP-binding cassette sub-family C member 9
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005267 [potassium channel activity]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0006810 [transport]
GO:0006813 [potassium ion transport]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0008076 [voltage-gated potassium channel complex]
GO:0008152 [metabolic process]
GO:0008281 [sulfonylurea receptor activity]
GO:0008282 [ATP-sensitive potassium channel complex]
GO:0010107 [potassium ion import]
GO:0015459 [potassium channel regulator activity]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0030017 [sarcomere]
GO:0042383 [sarcolemma]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0044325 [ion channel binding]
GO:0051607 [defense response to virus]
GO:0055085 [transmembrane transport]
GO:0071805 [potassium ion transmembrane transport]
Show all
1549 aa
174.4 kDa
No >9
ABCC9-002
ENSP00000261201
ENST00000261201
O60706 [Direct mapping]
ATP-binding cassette sub-family C member 9
A0A024RAV7 [Target identity:100%; Query identity:100%]
ATP-binding cassette, sub-family C (CFTR/MRP), member 9, isoform CRA_b
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0006810 [transport]
GO:0006813 [potassium ion transport]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0008076 [voltage-gated potassium channel complex]
GO:0008152 [metabolic process]
GO:0008281 [sulfonylurea receptor activity]
GO:0008282 [ATP-sensitive potassium channel complex]
GO:0010107 [potassium ion import]
GO:0015459 [potassium channel regulator activity]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0044325 [ion channel binding]
GO:0051607 [defense response to virus]
GO:0055085 [transmembrane transport]
Show all
1549 aa
174.2 kDa
No >9
ABCC9-003
ENSP00000440521
ENST00000544039
H0YFV4 [Direct mapping]
ATP-binding cassette sub-family C member 9
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Show all
GO:0005524 [ATP binding]
GO:0006810 [transport]
GO:0006813 [potassium ion transport]
GO:0007165 [signal transduction]
GO:0008152 [metabolic process]
GO:0008281 [sulfonylurea receptor activity]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0055085 [transmembrane transport]
Show all
1176 aa
131.6 kDa
No >9
ABCC9-004
ENSP00000442604
ENST00000538350
G3V1N6 [Direct mapping]
ATP-binding cassette sub-family C member 9; ATP-binding cassette, sub-family C (CFTR/MRP), member 9, isoform CRA_a
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Show all
GO:0005524 [ATP binding]
GO:0006813 [potassium ion transport]
GO:0007165 [signal transduction]
GO:0008281 [sulfonylurea receptor activity]
GO:0016021 [integral component of membrane]
Show all
170 aa
19.2 kDa
No 3
ABCC9-005
ENSP00000317518
ENST00000326684
Q8N4N7 [Direct mapping]
ABCC9 protein; ATP-binding cassette sub-family C member 9
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Show all
GO:0005524 [ATP binding]
GO:0006813 [potassium ion transport]
GO:0007165 [signal transduction]
GO:0008281 [sulfonylurea receptor activity]
GO:0016021 [integral component of membrane]
Show all
149 aa
17 kDa
No 3
ABCC9-201
ENSP00000480233
ENST00000621589
Q8N4N7 [Direct mapping]
ABCC9 protein; ATP-binding cassette sub-family C member 9
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Show all
GO:0005524 [ATP binding]
GO:0006813 [potassium ion transport]
GO:0007165 [signal transduction]
GO:0008281 [sulfonylurea receptor activity]
GO:0016021 [integral component of membrane]
Show all
149 aa
17 kDa
No 3

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