Tissue expression of ABCC9 - Summary - The Human Protein Atlas

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ABCC9

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	ABCC9
Gene description	ATP-binding cassette, sub-family C (CFTR/MRP), member 9
Protein class	Disease related genes Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Mixed
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

RNA data suggests expression in selected tissues.

DATA RELIABILITY
Data reliability description	Antibody staining not consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Uncertain based on 1 antibody. HPA007279
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Mixed
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	ABCC9 (HGNC Symbol)
Synonyms	CMD1O, SUR2
Description	ATP-binding cassette, sub-family C (CFTR/MRP), member 9 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is thought to form ATP-sensitive potassium channels in cardiac, skeletal, and vascular and non-vascular smooth muscle. Protein structure suggests a role as the drug-binding channel-modulating subunit of the extra-pancreatic ATP-sensitive potassium channels. Mutations in this gene are associated with cardiomyopathy dilated type 1O. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2011]
Chromosome	12
Cytoband	p12.1
Chromosome location (bp)	21797401 - 21941402
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000069431 (version 83.38)
Entrez gene	10060
UniProt	O60706 (UniProt - Evidence at protein level)
neXtProt	NX_O60706
Antibodypedia	ABCC9 antibodies

PROTEIN BROWSER

ABCC9-001	ABCC9-002	ABCC9-003	ABCC9-004	ABCC9-005	ABCC9-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ABCC9-001 ENSP00000261200 ENST00000261200	O60706 [Direct mapping] ATP-binding cassette sub-family C member 9 Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0005215 [transporter activity] GO:0005267 [potassium channel activity] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006813 [potassium ion transport] GO:0007165 [signal transduction] GO:0007268 [synaptic transmission] GO:0008076 [voltage-gated potassium channel complex] GO:0008152 [metabolic process] GO:0008281 [sulfonylurea receptor activity] GO:0008282 [ATP-sensitive potassium channel complex] GO:0010107 [potassium ion import] GO:0015459 [potassium channel regulator activity] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0030017 [sarcomere] GO:0042383 [sarcolemma] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0044325 [ion channel binding] GO:0051607 [defense response to virus] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	1549 aa 174.4 kDa	No	>9
ABCC9-002 ENSP00000261201 ENST00000261201	O60706 [Direct mapping] ATP-binding cassette sub-family C member 9 A0A024RAV7 [Target identity:100%; Query identity:100%] ATP-binding cassette, sub-family C (CFTR/MRP), member 9, isoform CRA_b Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0005215 [transporter activity] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006813 [potassium ion transport] GO:0007165 [signal transduction] GO:0007268 [synaptic transmission] GO:0008076 [voltage-gated potassium channel complex] GO:0008152 [metabolic process] GO:0008281 [sulfonylurea receptor activity] GO:0008282 [ATP-sensitive potassium channel complex] GO:0010107 [potassium ion import] GO:0015459 [potassium channel regulator activity] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0044325 [ion channel binding] GO:0051607 [defense response to virus] GO:0055085 [transmembrane transport] Show all	1549 aa 174.2 kDa	No	>9
ABCC9-003 ENSP00000440521 ENST00000544039	H0YFV4 [Direct mapping] ATP-binding cassette sub-family C member 9 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005524 [ATP binding] GO:0006810 [transport] GO:0006813 [potassium ion transport] GO:0007165 [signal transduction] GO:0008152 [metabolic process] GO:0008281 [sulfonylurea receptor activity] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0055085 [transmembrane transport] Show all	1176 aa 131.6 kDa	No	>9
ABCC9-004 ENSP00000442604 ENST00000538350	G3V1N6 [Direct mapping] ATP-binding cassette sub-family C member 9; ATP-binding cassette, sub-family C (CFTR/MRP), member 9, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0005524 [ATP binding] GO:0006813 [potassium ion transport] GO:0007165 [signal transduction] GO:0008281 [sulfonylurea receptor activity] GO:0016021 [integral component of membrane] Show all	170 aa 19.2 kDa	No	3
ABCC9-005 ENSP00000317518 ENST00000326684	Q8N4N7 [Direct mapping] ABCC9 protein; ATP-binding cassette sub-family C member 9 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0005524 [ATP binding] GO:0006813 [potassium ion transport] GO:0007165 [signal transduction] GO:0008281 [sulfonylurea receptor activity] GO:0016021 [integral component of membrane] Show all	149 aa 17 kDa	No	3
ABCC9-201 ENSP00000480233 ENST00000621589	Q8N4N7 [Direct mapping] ABCC9 protein; ATP-binding cassette sub-family C member 9 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0005524 [ATP binding] GO:0006813 [potassium ion transport] GO:0007165 [signal transduction] GO:0008281 [sulfonylurea receptor activity] GO:0016021 [integral component of membrane] Show all	149 aa 17 kDa	No	3

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.