Expression of CLEC2D in cancer - Summary - The Human Protein Atlas

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CLEC2D

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CLEC2D
Gene description	C-type lectin domain family 2, member D
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (Daudi, HDLM-2, U-698)
HPA (normal tissue):	Tissue enhanced (lymph node)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues and immune cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA017649
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), urothelial cancer (favourable) and cervical cancer (favourable).
Renal cancer p<0.001 Urothelial cancer p<0.001 Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA017649

GENE INFORMATION
Gene name	CLEC2D (HGNC Symbol)
Synonyms	CLAX, LLT1, OCIL
Description	C-type lectin domain family 2, member D (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the natural killer cell receptor C-type lectin family. The encoded protein inhibits osteoclast formation and contains a transmembrane domain near the N-terminus as well as the C-type lectin-like extracellular domain. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Oct 2010]
Chromosome	12
Cytoband	p13.31
Chromosome location (bp)	9664969 - 9699555
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000069493 (version 83.38)
Entrez gene	29121
UniProt	Q9UHP7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UHP7
Antibodypedia	CLEC2D antibodies

PROTEIN BROWSER

CLEC2D-001	CLEC2D-005	CLEC2D-006	CLEC2D-008	CLEC2D-013	CLEC2D-014	CLEC2D-015	CLEC2D-016	CLEC2D-018

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CLEC2D-001 ENSP00000290855 ENST00000290855	Q9UHP7 [Direct mapping] C-type lectin domain family 2 member D Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0005783 [endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0030246 [carbohydrate binding] GO:0050776 [regulation of immune response] Show all	191 aa 21.8 kDa	No	1
CLEC2D-005 ENSP00000261340 ENST00000261340	Q9UHP7 [Direct mapping] C-type lectin domain family 2 member D Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0005783 [endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0030246 [carbohydrate binding] GO:0050776 [regulation of immune response] Show all	194 aa 22.3 kDa	No	1
CLEC2D-006 ENSP00000446028 ENST00000466035	H0YH49 [Direct mapping] C-type lectin domain family 2 member D Show all	Predicted intracellular proteins Show all		140 aa 16.2 kDa	No	0
CLEC2D-008 ENSP00000443177 ENST00000460309	H0YGG6 [Direct mapping] C-type lectin domain family 2 member D Show all	Predicted intracellular proteins Show all		133 aa 15.2 kDa	No	0
CLEC2D-013 ENSP00000437861 ENST00000544322	A0A0C4DGG4 [Direct mapping] C-type lectin domain family 2 member D Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all	GO:0016021 [integral component of membrane] Show all	106 aa 12.2 kDa	No	0
CLEC2D-014 ENSP00000413045 ENST00000430909	A0A0C4DG81 [Direct mapping] C-type lectin domain family 2 member D Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all	GO:0016021 [integral component of membrane] Show all	173 aa 20 kDa	No	0
CLEC2D-015 ENSP00000261339 ENST00000261339	Q9UHP7 [Direct mapping] C-type lectin domain family 2 member D W8JXM2 [Target identity:100%; Query identity:100%] C-type lectin domain family 2 member D variant 3 Show all	Predicted intracellular proteins Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0005783 [endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0030246 [carbohydrate binding] GO:0050776 [regulation of immune response] Show all	154 aa 17.7 kDa	No	0
CLEC2D-016 ENSP00000444818 ENST00000545918	Q9UHP7 [Direct mapping] C-type lectin domain family 2 member D Show all	Predicted intracellular proteins Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0005783 [endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0030246 [carbohydrate binding] GO:0050776 [regulation of immune response] Show all	95 aa 10.8 kDa	No	0
CLEC2D-018 ENSP00000443065 ENST00000543300	Q9UHP7 [Direct mapping] C-type lectin domain family 2 member D Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0005783 [endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0030246 [carbohydrate binding] GO:0050776 [regulation of immune response] Show all	132 aa 15 kDa	No	1

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