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RORA

GENERAL INFORMATION

Gene name

 RORA

Gene description

 RAR-related orphan receptor A

Protein class

 Nuclear receptors
Plasma proteins
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (Karpas-707, U-266/70, U-266/84)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB009861
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB009861

GENE INFORMATION

Gene name

 RORA (HGNC Symbol)

Synonyms

 NR1F1, ROR1, ROR2, ROR3, RZRA

Description

 RAR-related orphan receptor A (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Also, it has been shown to aid in the transcriptional regulation of some genes involved in circadian rhythm. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2014]

Chromosome

 15

Cytoband

 q22.2

Chromosome location (bp)

 60488284 - 61229319

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000069667 (version 83.38)

Entrez gene

 6095

UniProt

 P35398 (UniProt - Evidence at protein level)

neXtProt

 NX_P35398

Antibodypedia

 RORA antibodies

PROTEIN BROWSER
RORA-001
RORA-002
RORA-003
RORA-005
RORA-009
RORA-014

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RORA-001
ENSP00000335087
ENST00000335670
P35398 [Direct mapping]
Nuclear receptor ROR-alpha
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Nuclear receptors
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0001222 [transcription corepressor binding]
GO:0001223 [transcription coactivator binding]
GO:0001525 [angiogenesis]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006805 [xenobiotic metabolic process]
GO:0007623 [circadian rhythm]
GO:0008134 [transcription factor binding]
GO:0008142 [oxysterol binding]
GO:0008270 [zinc ion binding]
GO:0008589 [regulation of smoothened signaling pathway]
GO:0010467 [gene expression]
GO:0010575 [positive regulation of vascular endothelial growth factor production]
GO:0010906 [regulation of glucose metabolic process]
GO:0019218 [regulation of steroid metabolic process]
GO:0021930 [cerebellar granule cell precursor proliferation]
GO:0030522 [intracellular receptor signaling pathway]
GO:0032922 [circadian regulation of gene expression]
GO:0036315 [cellular response to sterol]
GO:0042692 [muscle cell differentiation]
GO:0042753 [positive regulation of circadian rhythm]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050728 [negative regulation of inflammatory response]
GO:0060850 [regulation of transcription involved in cell fate commitment]
GO:0070328 [triglyceride homeostasis]
GO:0071456 [cellular response to hypoxia]
GO:0072539 [T-helper 17 cell differentiation]
GO:0098531 [transcription factor activity, direct ligand regulated sequence-specific DNA binding]
GO:2000188 [regulation of cholesterol homeostasis]
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 523 aa
59 kDa 		No 0
RORA-002
ENSP00000309753
ENST00000309157
A0A0C4DFP5 [Direct mapping]
Nuclear receptor ROR-alpha; RAR-related orphan receptor A, isoform CRA_c
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Predicted intracellular proteins
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GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0030522 [intracellular receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
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 548 aa
62.3 kDa 		No 0
RORA-003
ENSP00000261523
ENST00000261523
P35398 [Direct mapping]
Nuclear receptor ROR-alpha
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Nuclear receptors
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0001222 [transcription corepressor binding]
GO:0001223 [transcription coactivator binding]
GO:0001525 [angiogenesis]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006805 [xenobiotic metabolic process]
GO:0006809 [nitric oxide biosynthetic process]
GO:0007623 [circadian rhythm]
GO:0008013 [beta-catenin binding]
GO:0008134 [transcription factor binding]
GO:0008142 [oxysterol binding]
GO:0008270 [zinc ion binding]
GO:0008589 [regulation of smoothened signaling pathway]
GO:0010467 [gene expression]
GO:0010575 [positive regulation of vascular endothelial growth factor production]
GO:0010906 [regulation of glucose metabolic process]
GO:0019218 [regulation of steroid metabolic process]
GO:0021702 [cerebellar Purkinje cell differentiation]
GO:0021930 [cerebellar granule cell precursor proliferation]
GO:0030522 [intracellular receptor signaling pathway]
GO:0032922 [circadian regulation of gene expression]
GO:0036315 [cellular response to sterol]
GO:0042692 [muscle cell differentiation]
GO:0042752 [regulation of circadian rhythm]
GO:0042753 [positive regulation of circadian rhythm]
GO:0043030 [regulation of macrophage activation]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046068 [cGMP metabolic process]
GO:0050728 [negative regulation of inflammatory response]
GO:0060850 [regulation of transcription involved in cell fate commitment]
GO:0070328 [triglyceride homeostasis]
GO:0071347 [cellular response to interleukin-1]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071456 [cellular response to hypoxia]
GO:0072539 [T-helper 17 cell differentiation]
GO:0098531 [transcription factor activity, direct ligand regulated sequence-specific DNA binding]
GO:2000188 [regulation of cholesterol homeostasis]
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 556 aa
63 kDa 		No 0
RORA-005
ENSP00000402971
ENST00000449337
A0A0C4DG53 [Direct mapping]
Nuclear receptor ROR-alpha
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Predicted intracellular proteins
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GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0030522 [intracellular receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
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 468 aa
53.5 kDa 		No 0
RORA-009
ENSP00000453322
ENST00000559343
H0YLS5 [Direct mapping]
Nuclear receptor ROR-alpha
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Predicted intracellular proteins
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GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
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 153 aa
16.8 kDa 		No 0
RORA-014
ENSP00000484955
ENST00000558904
A0A087X2G0 [Direct mapping]
Nuclear receptor ROR-alpha
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Predicted intracellular proteins
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 38 aa
4.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.