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DRD4

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GENERAL INFORMATION

Gene name

 DRD4

Gene description

 Dopamine receptor D4

Protein class

 FDA approved drug targets
G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Not detected

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Not detected
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 DRD4

Synonyms

Description

 Dopamine receptor D4 (HGNC Symbol)

Entrez gene summary

 This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 p15.5

Chromosome location (bp)

 637293 - 640706

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000069696 (version 83.38)

Entrez gene

 1815

UniProt

 P21917 (UniProt - Evidence at protein level)

neXtProt

 NX_P21917

Antibodypedia

 DRD4 antibodies

PROTEIN BROWSER
DRD4-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DRD4-001
ENSP00000176183
ENST00000176183
P21917 [Direct mapping]
D(4) dopamine receptor
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0000187 [activation of MAPK activity]
GO:0001591 [dopamine neurotransmitter receptor activity, coupled via Gi/Go]
GO:0001662 [behavioral fear response]
GO:0001963 [synaptic transmission, dopaminergic]
GO:0001975 [response to amphetamine]
GO:0004930 [G-protein coupled receptor activity]
GO:0004952 [dopamine neurotransmitter receptor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005938 [cell cortex]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007194 [negative regulation of adenylate cyclase activity]
GO:0007195 [adenylate cyclase-inhibiting dopamine receptor signaling pathway]
GO:0007212 [dopamine receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007606 [sensory perception of chemical stimulus]
GO:0007614 [short-term memory]
GO:0007623 [circadian rhythm]
GO:0008144 [drug binding]
GO:0008227 [G-protein coupled amine receptor activity]
GO:0008306 [associative learning]
GO:0008344 [adult locomotory behavior]
GO:0008355 [olfactory learning]
GO:0009648 [photoperiodism]
GO:0012506 [vesicle membrane]
GO:0015459 [potassium channel regulator activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0017124 [SH3 domain binding]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030818 [negative regulation of cAMP biosynthetic process]
GO:0032417 [positive regulation of sodium:proton antiporter activity]
GO:0033674 [positive regulation of kinase activity]
GO:0034776 [response to histamine]
GO:0035176 [social behavior]
GO:0035240 [dopamine binding]
GO:0042053 [regulation of dopamine metabolic process]
GO:0042417 [dopamine metabolic process]
GO:0042596 [fear response]
GO:0042752 [regulation of circadian rhythm]
GO:0042802 [identical protein binding]
GO:0043025 [neuronal cell body]
GO:0043195 [terminal bouton]
GO:0043197 [dendritic spine]
GO:0043679 [axon terminus]
GO:0046928 [regulation of neurotransmitter secretion]
GO:0048148 [behavioral response to cocaine]
GO:0048149 [behavioral response to ethanol]
GO:0048545 [response to steroid hormone]
GO:0050482 [arachidonic acid secretion]
GO:0050709 [negative regulation of protein secretion]
GO:0050804 [modulation of synaptic transmission]
GO:0050848 [regulation of calcium-mediated signaling]
GO:0051586 [positive regulation of dopamine uptake involved in synaptic transmission]
GO:0060041 [retina development in camera-type eye]
GO:0060080 [inhibitory postsynaptic potential]
GO:0060406 [positive regulation of penile erection]
GO:1901386 [negative regulation of voltage-gated calcium channel activity]
GO:2000463 [positive regulation of excitatory postsynaptic potential]
Show all
 419 aa
43.9 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.