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TGFBR3

GENERAL INFORMATION

Gene name

 TGFBR3

Gene description

 Transforming growth factor, beta receptor III

Protein class

 Cancer-related genes
Plasma proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Membrane,Secreted

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (ASC TERT1, U-2197)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and membranous expression several cell types, most abundant in testicular Leydig cells, placental trophoblasts, renal glomeruli and basal cells of squamous epithelium.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA008257 , CAB018971
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PROGNOSTIC SUMMARY
Prognostic marker in thyroid cancer (unfavourable), endometrial cancer (unfavourable), head and neck cancer (favourable) and renal cancer (favourable).
0.00.10.20.30.40.50.60.70.80.91.0 0 1 2 3 4 5 6 7 8 91011121314 Thyroid cancer p<0.001
0.00.10.20.30.40.50.60.70.80.91.0 0 1 2 3 4 5 6 7 8 9101112131415161718 Endometrial cancer p<0.001
0.00.10.20.30.40.50.60.70.80.91.0 0 1 2 3 4 5 6 7 8 91011121314151617 Head and neck cancer p<0.001
0.00.10.20.30.40.50.60.70.80.91.0 0 1 2 3 4 5 6 7 8 910111213141516 Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all
0.05.0101520253035404550556065FPKMBreast cancer (BRCA)Cervical cancer (CESC)Colorectal cancer (COAD,READ)Endometrial cancer (UCEC)Glioma (GBM)Head and neck cancer (HNSC)Liver cancer (LIHC)Lung cancer (LUAD,LUSC)Melanoma (SKCM)Ovarian cancer (OV)Pancreatic cancer (PAAD)Prostate cancer (PRAD)Renal cancer (KICH,KIRC,KIRP)Stomach cancer (STAD)Testis cancer (TGCT)Thyroid cancer (THCA)Urothelial cancer (BLCA)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA008257
CAB018971

Cancer

Cancer staining

Protein
expression of
normal tissue
Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue
Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

 Weak cytoplasmic staining was observed in gliomas. Remaining cancer tissues were generally negative.

GENE INFORMATION

Gene name

 TGFBR3 (HGNC Symbol)

Synonyms

 betaglycan, BGCAN

Description

 Transforming growth factor, beta receptor III (HGNC Symbol)

Entrez gene summary

 This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[provided by RefSeq, Sep 2010]

Chromosome

 1

Cytoband

 p22.1

Chromosome location (bp)

 91680343 - 91906335

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000069702 (version 83.38)

Entrez gene

 7049

UniProt

 Q03167 (UniProt - Evidence at protein level)

neXtProt

 NX_Q03167

Antibodypedia

 TGFBR3 antibodies

PROTEIN BROWSER
TGFBR3-001
TGFBR3-002
TGFBR3-006
TGFBR3-009
TGFBR3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TGFBR3-001
ENSP00000359426
ENST00000370399
Q03167 [Direct mapping]
Transforming growth factor beta receptor type 3
A0A0A8KWK3 [Target identity:100%; Query identity:100%]
Transforming growth factor, beta receptor III; Transforming growth factor, beta receptor III (Betaglycan, 300kDa), isoform CRA_b
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001837 [epithelial to mesenchymal transition]
GO:0001889 [liver development]
GO:0003007 [heart morphogenesis]
GO:0005024 [transforming growth factor beta-activated receptor activity]
GO:0005114 [type II transforming growth factor beta receptor binding]
GO:0005160 [transforming growth factor beta receptor binding]
GO:0005515 [protein binding]
GO:0005539 [glycosaminoglycan binding]
GO:0005615 [extracellular space]
GO:0005887 [integral component of plasma membrane]
GO:0006955 [immune response]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008201 [heparin binding]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0015026 [coreceptor activity]
GO:0016049 [cell growth]
GO:0016477 [cell migration]
GO:0030165 [PDZ domain binding]
GO:0030509 [BMP signaling pathway]
GO:0032354 [response to follicle-stimulating hormone]
GO:0034673 [inhibin-betaglycan-ActRII complex]
GO:0034695 [response to prostaglandin E]
GO:0034699 [response to luteinizing hormone]
GO:0035556 [intracellular signal transduction]
GO:0043235 [receptor complex]
GO:0046332 [SMAD binding]
GO:0050431 [transforming growth factor beta binding]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0051271 [negative regulation of cellular component movement]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060021 [palate development]
GO:0060038 [cardiac muscle cell proliferation]
GO:0060216 [definitive hemopoiesis]
GO:0060317 [cardiac epithelial to mesenchymal transition]
GO:0060318 [definitive erythrocyte differentiation]
GO:0060347 [heart trabecula formation]
GO:0060389 [pathway-restricted SMAD protein phosphorylation]
GO:0070062 [extracellular exosome]
GO:0070123 [transforming growth factor beta receptor activity, type III]
Show all
 850 aa
93.4 kDa 		Yes 1
TGFBR3-002
ENSP00000432638
ENST00000465892
Q03167 [Direct mapping]
Transforming growth factor beta receptor type 3
A0A0A8KWK3 [Target identity:100%; Query identity:100%]
Transforming growth factor, beta receptor III; Transforming growth factor, beta receptor III (Betaglycan, 300kDa), isoform CRA_b
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001837 [epithelial to mesenchymal transition]
GO:0001889 [liver development]
GO:0003007 [heart morphogenesis]
GO:0005024 [transforming growth factor beta-activated receptor activity]
GO:0005114 [type II transforming growth factor beta receptor binding]
GO:0005160 [transforming growth factor beta receptor binding]
GO:0005515 [protein binding]
GO:0005539 [glycosaminoglycan binding]
GO:0005615 [extracellular space]
GO:0005887 [integral component of plasma membrane]
GO:0006955 [immune response]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008201 [heparin binding]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0015026 [coreceptor activity]
GO:0016049 [cell growth]
GO:0016477 [cell migration]
GO:0030165 [PDZ domain binding]
GO:0030509 [BMP signaling pathway]
GO:0032354 [response to follicle-stimulating hormone]
GO:0034673 [inhibin-betaglycan-ActRII complex]
GO:0034695 [response to prostaglandin E]
GO:0034699 [response to luteinizing hormone]
GO:0035556 [intracellular signal transduction]
GO:0043235 [receptor complex]
GO:0046332 [SMAD binding]
GO:0050431 [transforming growth factor beta binding]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0051271 [negative regulation of cellular component movement]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060021 [palate development]
GO:0060038 [cardiac muscle cell proliferation]
GO:0060216 [definitive hemopoiesis]
GO:0060317 [cardiac epithelial to mesenchymal transition]
GO:0060318 [definitive erythrocyte differentiation]
GO:0060347 [heart trabecula formation]
GO:0060389 [pathway-restricted SMAD protein phosphorylation]
GO:0070062 [extracellular exosome]
GO:0070123 [transforming growth factor beta receptor activity, type III]
Show all
 850 aa
93.4 kDa 		Yes 1
TGFBR3-006
ENSP00000436127
ENST00000525962
Q03167 [Direct mapping]
Transforming growth factor beta receptor type 3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001837 [epithelial to mesenchymal transition]
GO:0001889 [liver development]
GO:0003007 [heart morphogenesis]
GO:0005024 [transforming growth factor beta-activated receptor activity]
GO:0005114 [type II transforming growth factor beta receptor binding]
GO:0005160 [transforming growth factor beta receptor binding]
GO:0005515 [protein binding]
GO:0005539 [glycosaminoglycan binding]
GO:0005615 [extracellular space]
GO:0005887 [integral component of plasma membrane]
GO:0006955 [immune response]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008201 [heparin binding]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0015026 [coreceptor activity]
GO:0016049 [cell growth]
GO:0016477 [cell migration]
GO:0030165 [PDZ domain binding]
GO:0030509 [BMP signaling pathway]
GO:0032354 [response to follicle-stimulating hormone]
GO:0034673 [inhibin-betaglycan-ActRII complex]
GO:0034695 [response to prostaglandin E]
GO:0034699 [response to luteinizing hormone]
GO:0035556 [intracellular signal transduction]
GO:0043235 [receptor complex]
GO:0046332 [SMAD binding]
GO:0050431 [transforming growth factor beta binding]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0051271 [negative regulation of cellular component movement]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060021 [palate development]
GO:0060038 [cardiac muscle cell proliferation]
GO:0060216 [definitive hemopoiesis]
GO:0060317 [cardiac epithelial to mesenchymal transition]
GO:0060318 [definitive erythrocyte differentiation]
GO:0060347 [heart trabecula formation]
GO:0060389 [pathway-restricted SMAD protein phosphorylation]
GO:0070062 [extracellular exosome]
GO:0070123 [transforming growth factor beta receptor activity, type III]
Show all
 851 aa
93.5 kDa 		Yes 1
TGFBR3-009
ENSP00000395975
ENST00000417833
E9PAW7 [Direct mapping]
Transforming growth factor beta receptor type 3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 35 aa
3.5 kDa 		Yes 0
TGFBR3-201
ENSP00000212355
ENST00000212355
Q03167 [Direct mapping]
Transforming growth factor beta receptor type 3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0001837 [epithelial to mesenchymal transition]
GO:0001889 [liver development]
GO:0003007 [heart morphogenesis]
GO:0005024 [transforming growth factor beta-activated receptor activity]
GO:0005114 [type II transforming growth factor beta receptor binding]
GO:0005160 [transforming growth factor beta receptor binding]
GO:0005515 [protein binding]
GO:0005539 [glycosaminoglycan binding]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005887 [integral component of plasma membrane]
GO:0006461 [protein complex assembly]
GO:0006955 [immune response]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007181 [transforming growth factor beta receptor complex assembly]
GO:0008201 [heparin binding]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0015026 [coreceptor activity]
GO:0016049 [cell growth]
GO:0016477 [cell migration]
GO:0017134 [fibroblast growth factor binding]
GO:0030165 [PDZ domain binding]
GO:0030509 [BMP signaling pathway]
GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0031100 [organ regeneration]
GO:0032354 [response to follicle-stimulating hormone]
GO:0034673 [inhibin-betaglycan-ActRII complex]
GO:0034695 [response to prostaglandin E]
GO:0034699 [response to luteinizing hormone]
GO:0035556 [intracellular signal transduction]
GO:0043235 [receptor complex]
GO:0043393 [regulation of protein binding]
GO:0046332 [SMAD binding]
GO:0048185 [activin binding]
GO:0050431 [transforming growth factor beta binding]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0051271 [negative regulation of cellular component movement]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060021 [palate development]
GO:0060038 [cardiac muscle cell proliferation]
GO:0060216 [definitive hemopoiesis]
GO:0060317 [cardiac epithelial to mesenchymal transition]
GO:0060318 [definitive erythrocyte differentiation]
GO:0060347 [heart trabecula formation]
GO:0060389 [pathway-restricted SMAD protein phosphorylation]
GO:0070062 [extracellular exosome]
GO:0070123 [transforming growth factor beta receptor activity, type III]
Show all
 851 aa
93.5 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.