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ATP1B3

GENERAL INFORMATION

Gene name

 ATP1B3

Gene description

 ATPase, Na+/K+ transporting, beta 3 polypeptide

Protein class

 CD markers
Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

 Intracellular,Membrane

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and membranous expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA048963 , CAB020697
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), renal cancer (unfavourable) and endometrial cancer (favourable).
Liver cancer p<0.001
Renal cancer p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA048963
CAB020697

GENE INFORMATION

Gene name

 ATP1B3 (HGNC Symbol)

Synonyms

 CD298, FLJ29027

Description

 ATPase, Na+/K+ transporting, beta 3 polypeptide (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 3 subunit. This gene encodes a beta 3 subunit. A pseudogene exists for this gene, and it is located on chromosome 2. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 q23

Chromosome location (bp)

 141876124 - 141926514

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000069849 (version 83.38)

Entrez gene

 483

UniProt

 P54709 (UniProt - Evidence at protein level)

neXtProt

 NX_P54709

Antibodypedia

 ATP1B3 antibodies

PROTEIN BROWSER
ATP1B3-001
ATP1B3-004
ATP1B3-007
ATP1B3-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATP1B3-001
ENSP00000286371
ENST00000286371
P54709 [Direct mapping]
Sodium/potassium-transporting ATPase subunit beta-3
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CD markers
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001671 [ATPase activator activity]
GO:0005391 [sodium:potassium-exchanging ATPase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005890 [sodium:potassium-exchanging ATPase complex]
GO:0005901 [caveola]
GO:0006810 [transport]
GO:0006813 [potassium ion transport]
GO:0006814 [sodium ion transport]
GO:0006883 [cellular sodium ion homeostasis]
GO:0007596 [blood coagulation]
GO:0010107 [potassium ion import]
GO:0030001 [metal ion transport]
GO:0030007 [cellular potassium ion homeostasis]
GO:0032781 [positive regulation of ATPase activity]
GO:0034220 [ion transmembrane transport]
GO:0036376 [sodium ion export from cell]
GO:0042470 [melanosome]
GO:0050821 [protein stabilization]
GO:0050900 [leukocyte migration]
GO:0051117 [ATPase binding]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0072659 [protein localization to plasma membrane]
GO:0086009 [membrane repolarization]
GO:1901018 [positive regulation of potassium ion transmembrane transporter activity]
GO:1903278 [positive regulation of sodium ion export from cell]
GO:1903288 [positive regulation of potassium ion import]
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 279 aa
31.5 kDa 		No 1
ATP1B3-004
ENSP00000417522
ENST00000475483
C9JA36 [Direct mapping]
Sodium/potassium-transporting ATPase subunit beta-3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005890 [sodium:potassium-exchanging ATPase complex]
GO:0006813 [potassium ion transport]
GO:0006814 [sodium ion transport]
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 133 aa
15 kDa 		No 0
ATP1B3-007
ENSP00000418353
ENST00000462082
C9J6S2 [Direct mapping]
Sodium/potassium-transporting ATPase subunit beta-3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005890 [sodium:potassium-exchanging ATPase complex]
GO:0006813 [potassium ion transport]
GO:0006814 [sodium ion transport]
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 89 aa
10 kDa 		No 0
ATP1B3-008
ENSP00000419962
ENST00000495216
C9JXZ1 [Direct mapping]
Sodium/potassium-transporting ATPase subunit beta-3
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005890 [sodium:potassium-exchanging ATPase complex]
GO:0006813 [potassium ion transport]
GO:0006814 [sodium ion transport]
Show all
 119 aa
13.5 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.