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SCT

GENERAL INFORMATION

Gene name

 SCT

Gene description

 Secretin

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Not detected
HPA (normal tissue):Group enriched (duodenum, small intestine)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective cytoplasmic expression in small intestines.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA050961
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (unfavourable).
Colorectal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA050961

GENE INFORMATION

Gene name

 SCT

Synonyms

Description

 Secretin (HGNC Symbol)

Entrez gene summary

 Secretin belongs to the glucagon family. This protein is an endocrine hormone and its major site of production is the endocrine S cells located in the proximal small intestinal mucosa. The release of active secretin is stimulated by either fatty acids or an acidic pH in the duodenum. This hormone stimulates the secretion of bicarbonate-rich pancreatic fluids and has also been shown to regulate the growth and development of the stomach, small intestine, and pancreas. Secretin deficiency has been implicated in autistic syndrome, suggesting that the hormone could have a neuroendocrine function in addition to its role in digestion. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 p15.5

Chromosome location (bp)

 626431 - 627143

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000070031 (version 83.38)

Entrez gene

 6343

UniProt

 P09683 (UniProt - Evidence at protein level)

neXtProt

 NX_P09683

Antibodypedia

 SCT antibodies

PROTEIN BROWSER
SCT-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SCT-001
ENSP00000176195
ENST00000176195
P09683 [Direct mapping]
Secretin
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
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GO:0005102 [receptor binding]
GO:0005179 [hormone activity]
GO:0005575 [cellular_component]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0007420 [brain development]
GO:0008542 [visual learning]
GO:0021542 [dentate gyrus development]
GO:0030157 [pancreatic juice secretion]
GO:0030819 [positive regulation of cAMP biosynthetic process]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0047485 [protein N-terminus binding]
GO:0048566 [embryonic digestive tract development]
GO:0090187 [positive regulation of pancreatic juice secretion]
GO:0090274 [positive regulation of somatostatin secretion]
GO:0097150 [neuronal stem cell population maintenance]
GO:1903640 [negative regulation of gastrin-induced gastric acid secretion]
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 121 aa
13 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.