Expression of NUCB2 in cancer - Summary - The Human Protein Atlas

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NUCB2

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NUCB2
Gene description	Nucleobindin 2
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	14
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues, including immune cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA008395 , CAB015931
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable), renal cancer (unfavourable) and ovarian cancer (favourable).
Endometrial cancer p<0.001 Renal cancer p<0.001 Ovarian cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA008395	CAB015931

GENE INFORMATION
Gene name	NUCB2 (HGNC Symbol)
Synonyms	NEFA
Description	Nucleobindin 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein with a suggested role in calcium level maintenance, eating regulation in the hypothalamus, and release of tumor necrosis factor from vascular endothelial cells. This protein binds calcium and has EF-folding domains. [provided by RefSeq, Oct 2011]
Chromosome	11
Cytoband	p15.1
Chromosome location (bp)	17208153 - 17349974
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000070081 (version 83.38)
Entrez gene	4925
UniProt
neXtProt
Antibodypedia	NUCB2 antibodies

PROTEIN BROWSER

NUCB2-002	NUCB2-004	NUCB2-005	NUCB2-006	NUCB2-007	NUCB2-009	NUCB2-010	NUCB2-012	NUCB2-014	NUCB2-015	NUCB2-016	NUCB2-017	NUCB2-201	NUCB2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NUCB2-002 ENSP00000435160 ENST00000530527	E9PLE9 [Direct mapping] Nucleobindin-2 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	198 aa 23.6 kDa	Yes	0
NUCB2-004 ENSP00000320168 ENST00000323688	A0A087WSV8 [Direct mapping] Nucleobindin 2, isoform CRA_b; Nucleobindin-2 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	420 aa 50.2 kDa	Yes	0
NUCB2-005 ENSP00000436455 ENST00000529010	V9HW75 [Direct mapping] Epididymis secretory protein Li 109; Nucleobindin-2 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005164 [tumor necrosis factor receptor binding] GO:0005509 [calcium ion binding] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005640 [nuclear outer membrane] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005797 [Golgi medial cisterna] GO:0009749 [response to glucose] GO:0030818 [negative regulation of cAMP biosynthetic process] GO:0032099 [negative regulation of appetite] GO:0042594 [response to starvation] GO:0044752 [response to human chorionic gonadotropin] GO:0045599 [negative regulation of fat cell differentiation] GO:0046321 [positive regulation of fatty acid oxidation] GO:0046627 [negative regulation of insulin receptor signaling pathway] GO:0070093 [negative regulation of glucagon secretion] GO:1901142 [insulin metabolic process] GO:1990680 [response to melanocyte-stimulating hormone] GO:2000845 [positive regulation of testosterone secretion] Show all	420 aa 50.2 kDa	Yes	0
NUCB2-006 ENSP00000435558 ENST00000533738	E9PJP3 [Direct mapping] Nucleobindin-2 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	69 aa 8 kDa	Yes	0
NUCB2-007 ENSP00000436215 ENST00000526120	E9PJP3 [Direct mapping] Nucleobindin-2 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	69 aa 8 kDa	Yes	0
NUCB2-009 ENSP00000431136 ENST00000528644	E9PLR5 [Direct mapping] Nucleobindin-2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	34 aa 4 kDa	Yes	0
NUCB2-010 ENSP00000431328 ENST00000530964	E9PLR5 [Direct mapping] Nucleobindin-2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	34 aa 4 kDa	Yes	0
NUCB2-012 ENSP00000435968 ENST00000531172	E9PRQ3 [Direct mapping] Nucleobindin-2 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	39 aa 4.6 kDa	Yes	0
NUCB2-014 ENSP00000435787 ENST00000527580	H0YEG8 [Direct mapping] Nucleobindin-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	198 aa 23.7 kDa	No	0
NUCB2-015 ENSP00000432741 ENST00000527735	H0YD18 [Direct mapping] Nucleobindin-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	73 aa 8.5 kDa	No	0
NUCB2-016 ENSP00000431334 ENST00000529313	E9PLR0 [Direct mapping] Nucleobindin-2 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	195 aa 23.2 kDa	Yes	0
NUCB2-017 ENSP00000433194 ENST00000533926	E9PM22 [Direct mapping] Nucleobindin-2 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	90 aa 10.5 kDa	Yes	0
NUCB2-201 ENSP00000408702 ENST00000458064	Q2L696 [Direct mapping] Nucb2 splice variant; Nucleobindin-2 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	390 aa 46.6 kDa	Yes	0
NUCB2-202 ENSP00000481959 ENST00000622082	V9HW75 [Direct mapping] Epididymis secretory protein Li 109; Nucleobindin-2 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	420 aa 50.2 kDa	Yes	0

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The Human Protein Atlas

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