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Several gliomas, melanomas, squamous cell carcinomas, endometrial and ovarian cancers showed weak to moderate staining. Remaining tumor cells were weakly stained or negative.
Cancer tissues showed moderate to strong cytoplasmic and often nuclear staining. Lymphomas, stomach and liver cancers were negative.
GENE INFORMATION
Gene name
PFN2
Synonyms
Description
Profilin 2 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals. There are two alternatively spliced transcript variants encoding different isoforms described for this gene. [provided by RefSeq, Jul 2008]