Cell atlas - CLTCL1 - The Human Protein Atlas

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CLTCL1

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	CLTCL1
Gene description	Clathrin, heavy chain-like 1
Protein class	Cancer-related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to vesicles.
RNA cell category	Cell line enhanced (HMC-1)
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA075795
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HMC-1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to vesicles.

Main location

Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA075795	RH-30	Vesicles
	HPA075795	SiHa	No staining
	HPA075795	U-2 OS	Nucleoli
	HPA075795	U-2 OS	Vesicles

GENE INFORMATION
Gene name	CLTCL1 (HGNC Symbol)
Synonyms	CHC22, CLH22, CLTCL, CLTD
Description	Clathrin, heavy chain-like 1 (HGNC Symbol)
Entrez gene summary	This gene is a member of the clathrin heavy chain family and encodes a major protein of the polyhedral coat of coated pits and vesicles. Chromosomal aberrations involving this gene are associated with meningioma, DiGeorge syndrome, and velo-cardio-facial syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
Chromosome	22
Cytoband	q11.21
Chromosome location (bp)	19179473 - 19291716
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000070371 (version 83.38)
Entrez gene	8218
UniProt	P53675 (UniProt - Evidence at protein level)
neXtProt	NX_P53675
Antibodypedia	CLTCL1 antibodies

PROTEIN BROWSER

CLTCL1-001	CLTCL1-002	CLTCL1-004	CLTCL1-009	CLTCL1-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CLTCL1-001 ENSP00000441158 ENST00000427926	P53675 [Direct mapping] Clathrin heavy chain 2 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004871 [signal transducer activity] GO:0005198 [structural molecule activity] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005770 [late endosome] GO:0005802 [trans-Golgi network] GO:0005819 [spindle] GO:0005905 [coated pit] GO:0006886 [intracellular protein transport] GO:0006898 [receptor-mediated endocytosis] GO:0007067 [mitotic nuclear division] GO:0007165 [signal transduction] GO:0009653 [anatomical structure morphogenesis] GO:0016020 [membrane] GO:0016192 [vesicle-mediated transport] GO:0030130 [clathrin coat of trans-Golgi network vesicle] GO:0030132 [clathrin coat of coated pit] GO:0030135 [coated vesicle] GO:0030136 [clathrin-coated vesicle] GO:0042147 [retrograde transport, endosome to Golgi] GO:0046326 [positive regulation of glucose import] GO:0070062 [extracellular exosome] GO:0097443 [sorting endosome] Show all	1640 aa 187 kDa	No	0
CLTCL1-002 ENSP00000485020 ENST00000621271	P53675 [Direct mapping] Clathrin heavy chain 2 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004871 [signal transducer activity] GO:0005198 [structural molecule activity] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005770 [late endosome] GO:0005802 [trans-Golgi network] GO:0005819 [spindle] GO:0005905 [coated pit] GO:0006886 [intracellular protein transport] GO:0006898 [receptor-mediated endocytosis] GO:0007067 [mitotic nuclear division] GO:0007165 [signal transduction] GO:0009653 [anatomical structure morphogenesis] GO:0016020 [membrane] GO:0016192 [vesicle-mediated transport] GO:0030130 [clathrin coat of trans-Golgi network vesicle] GO:0030132 [clathrin coat of coated pit] GO:0030135 [coated vesicle] GO:0030136 [clathrin-coated vesicle] GO:0042147 [retrograde transport, endosome to Golgi] GO:0046326 [positive regulation of glucose import] GO:0070062 [extracellular exosome] GO:0097443 [sorting endosome] Show all	1583 aa 180.3 kDa	No	0
CLTCL1-004 ENSP00000443264 ENST00000449918	F5H5N6 [Direct mapping] Clathrin heavy chain 2 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0006886 [intracellular protein transport] GO:0016192 [vesicle-mediated transport] GO:0030130 [clathrin coat of trans-Golgi network vesicle] GO:0030132 [clathrin coat of coated pit] Show all	169 aa 18.7 kDa	No	0
CLTCL1-009 ENSP00000479237 ENST00000622493	A0A087WV74 [Direct mapping] Clathrin heavy chain 2 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005622 [intracellular] GO:0006886 [intracellular protein transport] GO:0016192 [vesicle-mediated transport] Show all	369 aa 43.1 kDa	No	0
CLTCL1-010 ENSP00000481031 ENST00000617926	A0A087WXH4 [Direct mapping] Clathrin heavy chain 2 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005622 [intracellular] GO:0006886 [intracellular protein transport] GO:0016192 [vesicle-mediated transport] Show all	463 aa 54.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.