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FGF22

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GENERAL INFORMATION

Gene name

 FGF22

Gene description

 Fibroblast growth factor 22

Protein class

 Predicted secreted proteins
RAS pathway related proteins

Predicted localization

 Secreted

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (AN3-CA)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (AN3-CA)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 FGF22

Synonyms

Description

 Fibroblast growth factor 22 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The mouse homolog of this gene was found to be preferentially expressed in the inner root sheath of the hair follicle, which suggested a role in hair development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Chromosome

 19

Cytoband

 p13.3

Chromosome location (bp)

 639879 - 644371

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000070388 (version 83.38)

Entrez gene

 27006

UniProt

 Q9HCT0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9HCT0

Antibodypedia

 FGF22 antibodies

PROTEIN BROWSER
FGF22-001
FGF22-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FGF22-001
ENSP00000215530
ENST00000215530
Q9HCT0 [Direct mapping]
Fibroblast growth factor 22
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0005104 [fibroblast growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005730 [nucleolus]
GO:0005794 [Golgi apparatus]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008083 [growth factor activity]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009986 [cell surface]
GO:0030154 [cell differentiation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
Show all
 170 aa
19.7 kDa 		Yes 0
FGF22-002
ENSP00000466004
ENST00000586042
K7ELB9 [Direct mapping]
Fibroblast growth factor
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
Show all
GO:0005104 [fibroblast growth factor receptor binding]
GO:0005576 [extracellular region]
GO:0008083 [growth factor activity]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
Show all
 165 aa
18.2 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.