Cell atlas - DGCR2 - The Human Protein Atlas

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DGCR2

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear bodies
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	DGCR2
Gene description	DiGeorge syndrome critical region gene 2
Protein class	Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nuclear bodies & nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Nuclear bodies (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA075929
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nuclear bodies & nucleoplasm.

Main location

Nucleoplasm (approved), Nuclear bodies (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA075929	HEK 293	Nucleoplasm
	HPA075929	HEK 293	Nuclear bodies
	HPA075929	SiHa	Nucleoplasm
	HPA075929	SiHa	Nuclear bodies
	HPA075929	U-2 OS	Nucleoplasm
	HPA075929	U-2 OS	Nuclear bodies

GENE INFORMATION
Gene name	DGCR2 (HGNC Symbol)
Synonyms	DGS-C, IDD, KIAA0163, LAN, SEZ-12
Description	DiGeorge syndrome critical region gene 2 (HGNC Symbol)
Entrez gene summary	Deletions of the 22q11.2 have been associated with a wide range of developmental defects (notably DiGeorge syndrome, velocardiofacial syndrome, conotruncal anomaly face syndrome and isolated conotruncal cardiac defects) classified under the acronym CATCH 22. The DGCR2 gene encodes a novel putative adhesion receptor protein, which could play a role in neural crest cells migration, a process which has been proposed to be altered in DiGeorge syndrome. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Chromosome	22
Cytoband	q11.21
Chromosome location (bp)	19036282 - 19122454
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000070413 (version 83.38)
Entrez gene	9993
UniProt	P98153 (UniProt - Evidence at transcript level)
neXtProt	NX_P98153
Antibodypedia	DGCR2 antibodies

PROTEIN BROWSER

DGCR2-001	DGCR2-201	DGCR2-202	DGCR2-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DGCR2-001 ENSP00000263196 ENST00000263196	P98153 [Direct mapping] Integral membrane protein DGCR2/IDD Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007155 [cell adhesion] GO:0009887 [organ morphogenesis] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] GO:0050890 [cognition] Show all	550 aa 60.8 kDa	Yes	1
DGCR2-201 ENSP00000440062 ENST00000537045	P98153 [Direct mapping] Integral membrane protein DGCR2/IDD Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007155 [cell adhesion] GO:0009887 [organ morphogenesis] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] GO:0050890 [cognition] Show all	509 aa 56.3 kDa	Yes	1
DGCR2-202 ENSP00000445069 ENST00000545799	F6SYP7 [Direct mapping] Integral membrane protein DGCR2/IDD Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	550 aa 60.9 kDa	Yes	1
DGCR2-203 ENSP00000482494 ENST00000615747	A0A087WZA8 [Direct mapping] Integral membrane protein DGCR2/IDD Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	328 aa 36.9 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.