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MNT

GENERAL INFORMATION

Gene name

 MNT

Gene description

 MAX network transcriptional repressor

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 MNT (HGNC Symbol)

Synonyms

 bHLHd3, MAD6, MXD6, ROX

Description

 MAX network transcriptional repressor (HGNC Symbol)

Entrez gene summary

 The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is likely a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA binding proteins at its N-terminal Sin3-interaction domain. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 p13.3

Chromosome location (bp)

 2384060 - 2401118

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000070444 (version 83.38)

Entrez gene

 4335

UniProt

 Q99583 (UniProt - Evidence at protein level)

neXtProt

 NX_Q99583

Antibodypedia

 MNT antibodies

PROTEIN BROWSER
MNT-001
MNT-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MNT-001
ENSP00000174618
ENST00000174618
Q99583 [Direct mapping]
Max-binding protein MNT
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Predicted intracellular proteins
Transcription factors
   Basic domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007275 [multicellular organismal development]
GO:0007569 [cell aging]
GO:0008285 [negative regulation of cell proliferation]
GO:0046983 [protein dimerization activity]
GO:0051726 [regulation of cell cycle]
GO:2001234 [negative regulation of apoptotic signaling pathway]
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 582 aa
62.3 kDa 		No 0
MNT-006
ENSP00000476269
ENST00000575394
V9GY02 [Direct mapping]
Max-binding protein MNT
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 33 aa
3.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.