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AP3M2

GENERAL INFORMATION

Gene name

 AP3M2

Gene description

 Adaptor-related protein complex 3, mu 2 subunit

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Approved based on 3 antibodies.
HPA045591 , HPA048380 , CAB014876
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable) and endometrial cancer (unfavourable).
Urothelial cancer p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA045591
HPA048380
CAB014876

GENE INFORMATION

Gene name

 AP3M2 (HGNC Symbol)

Synonyms

 AP47B, CLA20

Description

 Adaptor-related protein complex 3, mu 2 subunit (HGNC Symbol)

Entrez gene summary

 This gene encodes a subunit of the heterotetrameric adaptor-related protein comlex 3 (AP-3), which belongs to the adaptor complexes medium subunits family. The AP-3 complex plays a role in protein trafficking to lysosomes and specialized organelles. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Aug 2008]

Chromosome

 8

Cytoband

 p11.21

Chromosome location (bp)

 42152946 - 42171673

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000070718 (version 83.38)

Entrez gene

 10947

UniProt

 P53677 (UniProt - Evidence at transcript level)

neXtProt

 NX_P53677

Antibodypedia

 AP3M2 antibodies

PROTEIN BROWSER
AP3M2-001
AP3M2-002
AP3M2-003
AP3M2-006
AP3M2-007
AP3M2-013
AP3M2-014
AP3M2-015
AP3M2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AP3M2-001
ENSP00000380132
ENST00000396926
P53677 [Direct mapping]
AP-3 complex subunit mu-2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005794 [Golgi apparatus]
GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0008089 [anterograde axon cargo transport]
GO:0016192 [vesicle-mediated transport]
GO:0030119 [AP-type membrane coat adaptor complex]
GO:0030131 [clathrin adaptor complex]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0048490 [anterograde synaptic vesicle transport]
Show all
 418 aa
47 kDa 		No 0
AP3M2-002
ENSP00000428787
ENST00000518421
P53677 [Direct mapping]
AP-3 complex subunit mu-2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005794 [Golgi apparatus]
GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0008089 [anterograde axon cargo transport]
GO:0016192 [vesicle-mediated transport]
GO:0030119 [AP-type membrane coat adaptor complex]
GO:0030131 [clathrin adaptor complex]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0048490 [anterograde synaptic vesicle transport]
Show all
 418 aa
47 kDa 		No 0
AP3M2-003
ENSP00000429435
ENST00000517922
E7ER80 [Direct mapping]
AP-3 complex subunit mu-2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030131 [clathrin adaptor complex]
Show all
 268 aa
30.4 kDa 		No 0
AP3M2-006
ENSP00000430616
ENST00000521280
E5RJ52 [Direct mapping]
AP-3 complex subunit mu-2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006886 [intracellular protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030131 [clathrin adaptor complex]
Show all
 287 aa
31.8 kDa 		No 0
AP3M2-007
ENSP00000429515
ENST00000522288
E5RI83 [Direct mapping]
AP-3 complex subunit mu-2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030131 [clathrin adaptor complex]
Show all
 139 aa
16 kDa 		No 0
AP3M2-013
ENSP00000428279
ENST00000522606
H0YAY4 [Direct mapping]
AP-3 complex subunit mu-2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 97 aa
10.6 kDa 		No 0
AP3M2-014
ENSP00000429037
ENST00000517499
H0YBA0 [Direct mapping]
AP-3 complex subunit mu-2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030131 [clathrin adaptor complex]
Show all
 131 aa
14.7 kDa 		No 0
AP3M2-015
ENSP00000430538
ENST00000517969
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 10 aa
1.2 kDa 		No 0
AP3M2-201
ENSP00000174653
ENST00000174653
P53677 [Direct mapping]
AP-3 complex subunit mu-2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005794 [Golgi apparatus]
GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0008089 [anterograde axon cargo transport]
GO:0016192 [vesicle-mediated transport]
GO:0030119 [AP-type membrane coat adaptor complex]
GO:0030131 [clathrin adaptor complex]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0048490 [anterograde synaptic vesicle transport]
Show all
 418 aa
47 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.