Fields »
ABOUT
HELP
BLOG
TESK2

GENERAL INFORMATION

Gene name

 TESK2

Gene description

 Testis-specific kinase 2

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in a subset of tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA027257
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (favourable).
Cervical cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA027257

GENE INFORMATION

Gene name

 TESK2

Synonyms

Description

 Testis-specific kinase 2 (HGNC Symbol)

Entrez gene summary

 This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain that is structurally similar to the kinase domains of testis-specific protein kinase-1 and the LIM motif-containing protein kinases (LIMKs). Its overall structure is most related to the former, indicating that it belongs to the TESK subgroup of the LIMK/TESK family of protein kinases. This gene is predominantly expressed in testis and prostate. The developmental expression pattern of the rat gene in testis suggests an important role for this gene in meitoic stages and/or early stages of spermiogenesis. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p34.1

Chromosome location (bp)

 45343883 - 45491166

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000070759 (version 83.38)

Entrez gene

 10420

UniProt

 Q96S53 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96S53

Antibodypedia

 TESK2 antibodies

PROTEIN BROWSER
TESK2-001
TESK2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TESK2-001
ENSP00000361158
ENST00000372086
Q96S53 [Direct mapping]
Dual specificity testis-specific protein kinase 2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0007283 [spermatogenesis]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030036 [actin cytoskeleton organization]
GO:0046872 [metal ion binding]
GO:0048041 [focal adhesion assembly]
Show all
 571 aa
63.6 kDa 		No 0
TESK2-002
ENSP00000361156
ENST00000372084
Q96S53 [Direct mapping]
Dual specificity testis-specific protein kinase 2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006468 [protein phosphorylation]
GO:0007283 [spermatogenesis]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030036 [actin cytoskeleton organization]
GO:0046872 [metal ion binding]
GO:0048041 [focal adhesion assembly]
Show all
 542 aa
60.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.