Expression of ATP2B1 in cancer - Summary - The Human Protein Atlas

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ATP2B1

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ATP2B1
Gene description	ATPase, Ca++ transporting, plasma membrane 1
Protein class	Enzymes Plasma proteins Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic and membranous expression. Most abundant in CNS.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA011166 , HPA012945 , CAB005605
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA011166	HPA012945	CAB005605

GENE INFORMATION
Gene name	ATP2B1 (HGNC Symbol)
Synonyms	PMCA1
Description	ATPase, Ca++ transporting, plasma membrane 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 1. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	q21.33
Chromosome location (bp)	89588049 - 89709300
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000070961 (version 83.38)
Entrez gene	490
UniProt	P20020 (UniProt - Evidence at protein level)
neXtProt	NX_P20020
Antibodypedia	ATP2B1 antibodies

PROTEIN BROWSER

ATP2B1-001	ATP2B1-002	ATP2B1-003	ATP2B1-004	ATP2B1-005	ATP2B1-010	ATP2B1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATP2B1-001 ENSP00000392043 ENST00000428670	P20020 [Direct mapping] Plasma membrane calcium-transporting ATPase 1 A0A024RBC7 [Target identity:100%; Query identity:100%] Calcium-transporting ATPase Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003407 [neural retina development] GO:0005388 [calcium-transporting ATPase activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006874 [cellular calcium ion homeostasis] GO:0007420 [brain development] GO:0007568 [aging] GO:0007596 [blood coagulation] GO:0008152 [metabolic process] GO:0009409 [response to cold] GO:0009898 [cytoplasmic side of plasma membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0016324 [apical plasma membrane] GO:0030165 [PDZ domain binding] GO:0032590 [dendrite membrane] GO:0032591 [dendritic spine membrane] GO:0032809 [neuronal cell body membrane] GO:0034220 [ion transmembrane transport] GO:0045121 [membrane raft] GO:0045177 [apical part of cell] GO:0046872 [metal ion binding] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0070588 [calcium ion transmembrane transport] GO:0071305 [cellular response to vitamin D] GO:0071386 [cellular response to corticosterone stimulus] GO:0098655 [cation transmembrane transport] GO:1901660 [calcium ion export] Show all	1220 aa 134.7 kDa	No	>9
ATP2B1-002 ENSP00000352054 ENST00000359142	P20020 [Direct mapping] Plasma membrane calcium-transporting ATPase 1 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005388 [calcium-transporting ATPase activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006874 [cellular calcium ion homeostasis] GO:0007596 [blood coagulation] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030165 [PDZ domain binding] GO:0034220 [ion transmembrane transport] GO:0046872 [metal ion binding] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0070588 [calcium ion transmembrane transport] GO:0098655 [cation transmembrane transport] Show all	1176 aa 129.5 kDa	No	>9
ATP2B1-003 ENSP00000376869 ENST00000393164	E7ERY9 [Direct mapping] Calcium-transporting ATPase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005388 [calcium-transporting ATPase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005886 [plasma membrane] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0046872 [metal ion binding] GO:0070588 [calcium ion transmembrane transport] Show all	963 aa 106.9 kDa	No	8
ATP2B1-004 ENSP00000447096 ENST00000550716	H0YHH6 [Direct mapping] Plasma membrane calcium-transporting ATPase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005388 [calcium-transporting ATPase activity] GO:0005524 [ATP binding] GO:0016021 [integral component of membrane] GO:0070588 [calcium ion transmembrane transport] Show all	162 aa 18.5 kDa	No	1
ATP2B1-005 ENSP00000447041 ENST00000551310	F8W1V5 [Direct mapping] Plasma membrane calcium-transporting ATPase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all		101 aa 11.5 kDa	No	1
ATP2B1-010 ENSP00000489171 ENST00000635033		Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005388 [calcium-transporting ATPase activity] Show all	300 aa 33.6 kDa	No	2
ATP2B1-201 ENSP00000261173 ENST00000261173	P20020 [Direct mapping] Plasma membrane calcium-transporting ATPase 1 A0A024RBC7 [Target identity:100%; Query identity:100%] Calcium-transporting ATPase Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005388 [calcium-transporting ATPase activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006874 [cellular calcium ion homeostasis] GO:0007596 [blood coagulation] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030165 [PDZ domain binding] GO:0034220 [ion transmembrane transport] GO:0046872 [metal ion binding] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0070588 [calcium ion transmembrane transport] GO:0098655 [cation transmembrane transport] Show all	1220 aa 134.7 kDa	No	>9

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The Human Protein Atlas

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