Expression of MAP4K4 in cancer - Summary - The Human Protein Atlas

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MAP4K4

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MAP4K4
Gene description	Mitogen-activated protein kinase kinase kinase kinase 4
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	15
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several different tissues types.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification. Caution, Splice and/or transcript discrepancy exists.
Reliability score	Uncertain based on 1 antibody. HPA008476
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and lung cancer (unfavourable).
Renal cancer p<0.001 Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA008476

GENE INFORMATION
Gene name	MAP4K4 (HGNC Symbol)
Synonyms	FLH21957, HGK, NIK
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	q11.2
Chromosome location (bp)	101696850 - 101894689
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000071054 (version 83.38)
Entrez gene	9448
UniProt	O95819 (UniProt - Evidence at protein level)
neXtProt	NX_O95819
Antibodypedia	MAP4K4 antibodies

PROTEIN BROWSER

MAP4K4-001	MAP4K4-002	MAP4K4-003	MAP4K4-004	MAP4K4-005	MAP4K4-006	MAP4K4-008	MAP4K4-011	MAP4K4-015	MAP4K4-201	MAP4K4-202	MAP4K4-203	MAP4K4-204	MAP4K4-205	MAP4K4-206

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MAP4K4-001 ENSP00000314363 ENST00000347699	O95819 [Direct mapping] Mitogen-activated protein kinase kinase kinase kinase 4 Show all	Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0004111 [creatine kinase activity] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0007346 [regulation of mitotic cell cycle] GO:0031098 [stress-activated protein kinase signaling cascade] GO:0032147 [activation of protein kinase activity] GO:0035556 [intracellular signal transduction] GO:0043066 [negative regulation of apoptotic process] GO:0046328 [regulation of JNK cascade] GO:0048812 [neuron projection morphogenesis] Show all	1239 aa 142.1 kDa	No	0
MAP4K4-002 ENSP00000392830 ENST00000425019	E7EN19 [Direct mapping] Mitogen-activated protein kinase kinase kinase kinase 4 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0006468 [protein phosphorylation] GO:0007346 [regulation of mitotic cell cycle] GO:0031098 [stress-activated protein kinase signaling cascade] GO:0032147 [activation of protein kinase activity] GO:0048812 [neuron projection morphogenesis] Show all	1272 aa 144.9 kDa	No	0
MAP4K4-003 ENSP00000389752 ENST00000413150	E7ENQ1 [Direct mapping] Mitogen-activated protein kinase kinase kinase kinase 4 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0006468 [protein phosphorylation] GO:0007346 [regulation of mitotic cell cycle] GO:0031098 [stress-activated protein kinase signaling cascade] GO:0032147 [activation of protein kinase activity] GO:0048812 [neuron projection morphogenesis] Show all	1154 aa 132.2 kDa	No	0
MAP4K4-004 ENSP00000409720 ENST00000417294	H7C360 [Direct mapping] Mitogen-activated protein kinase kinase kinase kinase 4 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0006468 [protein phosphorylation] GO:0007346 [regulation of mitotic cell cycle] GO:0031098 [stress-activated protein kinase signaling cascade] GO:0032147 [activation of protein kinase activity] GO:0048812 [neuron projection morphogenesis] Show all	1170 aa 134.2 kDa	No	0
MAP4K4-005 ENSP00000387370 ENST00000456652	E7EX83 [Direct mapping] Mitogen-activated protein kinase kinase kinase kinase 4 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0006468 [protein phosphorylation] GO:0007346 [regulation of mitotic cell cycle] GO:0031098 [stress-activated protein kinase signaling cascade] GO:0032147 [activation of protein kinase activity] GO:0048812 [neuron projection morphogenesis] Show all	1038 aa 119 kDa	No	0
MAP4K4-006 ENSP00000396066 ENST00000421882	H7C0P6 [Direct mapping] Mitogen-activated protein kinase kinase kinase kinase 4 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0005622 [intracellular] GO:0007346 [regulation of mitotic cell cycle] GO:0031098 [stress-activated protein kinase signaling cascade] GO:0032147 [activation of protein kinase activity] GO:0048812 [neuron projection morphogenesis] Show all	1056 aa 121.3 kDa	No	0
MAP4K4-008 ENSP00000403016 ENST00000427603	E7ETN6 [Direct mapping] Mitogen-activated protein kinase kinase kinase kinase 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0006468 [protein phosphorylation] GO:0007346 [regulation of mitotic cell cycle] GO:0031098 [stress-activated protein kinase signaling cascade] GO:0032147 [activation of protein kinase activity] GO:0048812 [neuron projection morphogenesis] Show all	102 aa 11.4 kDa	No	0
MAP4K4-011 ENSP00000414766 ENST00000418101	H7C3Z6 [Direct mapping] Mitogen-activated protein kinase kinase kinase kinase 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0005622 [intracellular] GO:0007346 [regulation of mitotic cell cycle] GO:0031098 [stress-activated protein kinase signaling cascade] GO:0032147 [activation of protein kinase activity] GO:0048812 [neuron projection morphogenesis] Show all	258 aa 31.1 kDa	No	0
MAP4K4-015 ENSP00000489579 ENST00000634702		MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	1165 aa 133.4 kDa	No	0
MAP4K4-201 ENSP00000303600 ENST00000302217	C9J840 [Direct mapping] Mitogen-activated protein kinase kinase kinase kinase 4 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0006468 [protein phosphorylation] GO:0007346 [regulation of mitotic cell cycle] GO:0031098 [stress-activated protein kinase signaling cascade] GO:0032147 [activation of protein kinase activity] GO:0048812 [neuron projection morphogenesis] Show all	987 aa 113.6 kDa	No	0
MAP4K4-202 ENSP00000313644 ENST00000324219	G5E948 [Direct mapping] Mitogen-activated protein kinase kinase kinase kinase 4 Show all	MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0006468 [protein phosphorylation] GO:0007346 [regulation of mitotic cell cycle] GO:0031098 [stress-activated protein kinase signaling cascade] GO:0032147 [activation of protein kinase activity] GO:0048812 [neuron projection morphogenesis] Show all	1235 aa 141.1 kDa	No	0
MAP4K4-203 ENSP00000281111 ENST00000350198	G3XAA2 [Direct mapping] Mitogen-activated protein kinase kinase kinase kinase 4; Mitogen-activated protein kinase kinase kinase kinase 4, isoform CRA_c Show all	MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0006468 [protein phosphorylation] GO:0007346 [regulation of mitotic cell cycle] GO:0031098 [stress-activated protein kinase signaling cascade] GO:0032147 [activation of protein kinase activity] GO:0048812 [neuron projection morphogenesis] Show all	1165 aa 133.5 kDa	No	0
MAP4K4-204 ENSP00000343658 ENST00000350878	E7ESS2 [Direct mapping] Mitogen-activated protein kinase kinase kinase kinase 4; Mitogen-activated protein kinase kinase kinase kinase 4, isoform CRA_f Show all	MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0006468 [protein phosphorylation] GO:0007346 [regulation of mitotic cell cycle] GO:0031098 [stress-activated protein kinase signaling cascade] GO:0032147 [activation of protein kinase activity] GO:0048812 [neuron projection morphogenesis] Show all	1273 aa 145 kDa	No	0
MAP4K4-205 ENSP00000486116 ENST00000625522	A0A0D9SEY1 [Direct mapping] Mitogen-activated protein kinase kinase kinase kinase 4; Mitogen-activated protein kinase kinase kinase kinase 4, isoform CRA_a Show all	MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0006468 [protein phosphorylation] GO:0007346 [regulation of mitotic cell cycle] GO:0031098 [stress-activated protein kinase signaling cascade] GO:0032147 [activation of protein kinase activity] GO:0048812 [neuron projection morphogenesis] Show all	1320 aa 151.1 kDa	No	0
MAP4K4-206 ENSP00000487176 ENST00000627726	A0A0D9SG62 [Direct mapping] Mitogen-activated protein kinase kinase kinase kinase 4 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0006468 [protein phosphorylation] GO:0007346 [regulation of mitotic cell cycle] GO:0031098 [stress-activated protein kinase signaling cascade] GO:0032147 [activation of protein kinase activity] GO:0048812 [neuron projection morphogenesis] Show all	1044 aa 119.7 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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