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MGAT4A

GENERAL INFORMATION

Gene name

 MGAT4A

Gene description

 Mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A

Protein class

 Enzymes
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (BEWO, TIME)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression with a granular pattern in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA007608
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable) and breast cancer (unfavourable).
Endometrial cancer p<0.001
Breast cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA007608

GENE INFORMATION

Gene name

 MGAT4A (HGNC Symbol)

Synonyms

 GnT-4a, GnT-Iva

Description

 Mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A (HGNC Symbol)

Entrez gene summary

 This gene encodes a key glycosyltransferase that regulates the formation of tri- and multiantennary branching structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme B, catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc in a beta-1,4 linkage to the Man-alpha-1,3-Man-beta-1,4-GlcNAc arm of R-Man-alpha-1,6(GlcNAc-beta-1,2-Man-alpha-1,3)Man-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1-Asn. The encoded protein may play a role in regulating the availability of serum glycoproteins, oncogenesis, and differentiation. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q11.2

Chromosome location (bp)

 98619106 - 98731126

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000071073 (version 83.38)

Entrez gene

 11320

UniProt

 Q9UM21 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UM21

Antibodypedia

 MGAT4A antibodies

PROTEIN BROWSER
MGAT4A-001
MGAT4A-002
MGAT4A-006
MGAT4A-201
MGAT4A-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MGAT4A-001
ENSP00000264968
ENST00000264968
Q9UM21 [Direct mapping]
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A soluble form
Show all
Enzymes
   ENZYME proteins
   Transferases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006487 [protein N-linked glycosylation]
GO:0006491 [N-glycan processing]
GO:0008375 [acetylglucosaminyltransferase activity]
GO:0008454 [alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016757 [transferase activity, transferring glycosyl groups]
GO:0016758 [transferase activity, transferring hexosyl groups]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
Show all
 535 aa
61.5 kDa 		Yes 0
MGAT4A-002
ENSP00000386841
ENST00000409391
Q9UM21 [Direct mapping]
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A soluble form
Show all
Enzymes
   ENZYME proteins
   Transferases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006491 [N-glycan processing]
GO:0008454 [alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016758 [transferase activity, transferring hexosyl groups]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
Show all
 535 aa
61.5 kDa 		Yes 0
MGAT4A-006
ENSP00000475198
ENST00000495056
U3KPT4 [Direct mapping]
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005975 [carbohydrate metabolic process]
GO:0016020 [membrane]
GO:0016758 [transferase activity, transferring hexosyl groups]
Show all
 44 aa
5.1 kDa 		Yes 0
MGAT4A-201
ENSP00000377127
ENST00000393487
Q9UM21 [Direct mapping]
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A soluble form
Show all
Enzymes
   ENZYME proteins
   Transferases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006491 [N-glycan processing]
GO:0008454 [alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016758 [transferase activity, transferring hexosyl groups]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
Show all
 535 aa
61.5 kDa 		Yes 0
MGAT4A-202
ENSP00000404889
ENST00000414521
Q9UM21 [Direct mapping]
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A soluble form
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006491 [N-glycan processing]
GO:0008454 [alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016758 [transferase activity, transferring hexosyl groups]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
Show all
 423 aa
48.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.