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WDR1

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GENERAL INFORMATION

Gene name

 WDR1

Gene description

 WD repeat domain 1

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the cytosol.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Cytosol (validated)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Validated based on 3 antibodies.
CAB020804 , HPA036434 , HPA058132
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the cytosol.

Main location

 Cytosol (validated)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
CAB020804 A-431 No staining    
CAB020804 U-2 OS No staining    
CAB020804 U-251 MG Cytosol
HPA036434 A-431 Cytosol
HPA036434 U-2 OS Cytosol
HPA036434 U-251 MG Cytosol
HPA058132 A-431 No staining    
HPA058132 U-2 OS No staining    
HPA058132 U-251 MG Cytosol Intensity

GENE INFORMATION

Gene name

 WDR1

Synonyms

Description

 WD repeat domain 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein containing 9 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, mostly including a trp-asp at the C-terminal end. WD domains are involved in protein-protein interactions. The encoded protein may help induce the disassembly of actin filaments. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 p16.1

Chromosome location (bp)

 10074339 - 10116949

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000071127 (version 83.38)

Entrez gene

 9948

UniProt

 O75083 (UniProt - Evidence at protein level)

neXtProt

 NX_O75083

Antibodypedia

 WDR1 antibodies

PROTEIN BROWSER
WDR1-001
WDR1-002
WDR1-011
WDR1-201
WDR1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
WDR1-001
ENSP00000427687
ENST00000499869
O75083 [Direct mapping]
WD repeat-containing protein 1
V9HWG7 [Target identity:100%; Query identity:100%]
Epididymis secretory protein Li 52
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002102 [podosome]
GO:0002576 [platelet degranulation]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0007596 [blood coagulation]
GO:0007605 [sensory perception of sound]
GO:0030036 [actin cytoskeleton organization]
GO:0030054 [cell junction]
GO:0030168 [platelet activation]
GO:0030836 [positive regulation of actin filament depolymerization]
GO:0042995 [cell projection]
GO:0043209 [myelin sheath]
GO:0045214 [sarcomere organization]
GO:0048713 [regulation of oligodendrocyte differentiation]
GO:0060307 [regulation of ventricular cardiac muscle cell membrane repolarization]
GO:0070062 [extracellular exosome]
Show all
 606 aa
66.2 kDa 		No 0
WDR1-002
ENSP00000426725
ENST00000502702
O75083 [Direct mapping]
WD repeat-containing protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002102 [podosome]
GO:0002576 [platelet degranulation]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007596 [blood coagulation]
GO:0007605 [sensory perception of sound]
GO:0030054 [cell junction]
GO:0030168 [platelet activation]
GO:0042995 [cell projection]
GO:0070062 [extracellular exosome]
Show all
 466 aa
50.7 kDa 		No 0
WDR1-011
ENSP00000425481
ENST00000508079
D6RD66 [Direct mapping]
WD repeat-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
Show all
 245 aa
26.8 kDa 		No 0
WDR1-201
ENSP00000371889
ENST00000382451
O75083 [Direct mapping]
WD repeat-containing protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002102 [podosome]
GO:0002576 [platelet degranulation]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007596 [blood coagulation]
GO:0007605 [sensory perception of sound]
GO:0030054 [cell junction]
GO:0030168 [platelet activation]
GO:0042995 [cell projection]
GO:0070062 [extracellular exosome]
Show all
 466 aa
50.7 kDa 		No 0
WDR1-202
ENSP00000371890
ENST00000382452
O75083 [Direct mapping]
WD repeat-containing protein 1
V9HWG7 [Target identity:100%; Query identity:100%]
Epididymis secretory protein Li 52
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002102 [podosome]
GO:0002576 [platelet degranulation]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007596 [blood coagulation]
GO:0007605 [sensory perception of sound]
GO:0030054 [cell junction]
GO:0030168 [platelet activation]
GO:0042995 [cell projection]
GO:0070062 [extracellular exosome]
Show all
 606 aa
66.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.